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Publication

Property	Value
Working Groups	RG Wollnik
Subproject	RA1.2
Open Access	Yes
Publication Type	Journal Article
Peer Reviewed	Yes
PMID	34021162
DOI	10.1038/s41467-021-23327-1
Publication Year	2021
Title	Overarching control of autophagy and DNA damage response by CHD6 revealed by modeling a rare human pathology
Journal	Nature Communications
ISSN	2041-1723
eISSN	2041-1723
URL	http://dx.doi.org/10.1038/s41467-021-23327-1
Issue	1
Volume	12
Journal Abbreviation	Nat Commun
Authors	Kargapolova Y, Rehimi R, Kayserili H, Brühl J, Sofiadis K, Zirkel A, Palikyras S, Mizi A, Li Y, Yigit G, Hoischen A, Frank S, Russ N, Trautwein J, van Bon B, Gilissen C, Laugsch M, Gusmao EG, Josipovic N, Altmüller J, Nürnberg P, Längst G, Kaiser FJ, Watrin E, Brunner H, Rada-Iglesias A, Kurian L, Wollnik B, Bouazoune K, Papantonis A
First Author	Kargapolova Y
Last Author	Papantonis A
Scholia	Wikidata-based representation at Scholia

External Resources

nature.c...-1.pdfhttps://www.nature.com/articles/s41467-021-23327-1.pdf Article fulltext

gro-2/86739http://resolver.sub.uni-goettingen.de/purl?gro-2/86739 GRO.publications identifier

GSE135832https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE135832 NCBI GEO Dataset (GSE135832)

GSE136057https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE136057 NCBI GEO Dataset (GSE136057)

GSE29611https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE29611 NCBI GEO Dataset (GSE29611, reused)

GSE31477https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE31477 NCBI GEO Dataset (GSE31477, reused)

GSE32970https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE32970 NCBI GEO Dataset (GSE32970, reused)

GSE35239https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE35239 NCBI GEO Dataset (GSE35239, reused)

GSE124903https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE124903 NCBI GEO Dataset (GSE124903, reused)

GSE128351https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE128351 NCBI GEO Dataset (GSE128351, reused)

9606https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 NCBI taxonomy (human, Homo sapiens)

234100https://www.omim.org/entry/234100 OMIM identifier (234100, HSS)

0000-0003-2589-0364https://orcid.org/0000-0003-2589-0364 ORCID identifier (Bernd Wollnik)

PXD024803http://proteomecentral.proteomexchange.org/cgi/GetDataset?ID=PXD024803 Pride proteome dataset (PXD024803)

8https://prod.mbexc.uni-goettingen.de/literature/publications/8 Published Data Registry entry (MBExC, preprint)

1/402https://mbexc.uni-goettingen.de/archive/1/402 Research Data Archive (supplemental material)

05xy1nn52https://ror.org/05xy1nn52 ROR identifier (05xy1nn52, Multiscale Bioimaging)

021ft0n22https://ror.org/021ft0n22 ROR identifier (021ft0n22, University Medical Center Göttingen)

SCR_006442https://scicrunch.org/resolver/SCR_006442 SciCrunch identifier (RRID:SCR_006442, Bioconductor)

SCR_005476https://scicrunch.org/resolver/SCR_005476 SciCrunch identifier (RRID:SCR_005476, Bowtie)

SCR_015626https://scicrunch.org/resolver/SCR_015626 SciCrunch identifier (RRID:SCR_015626, ChAS)

SCR_015687https://scicrunch.org/resolver/SCR_015687 SciCrunch identifier (RRID:SCR_015687, DESeq2)

SCR_002285https://scicrunch.org/resolver/SCR_002285 SciCrunch identifier (RRID:SCR_002285, Fiji)

SCR_008520https://scicrunch.org/resolver/SCR_008520 SciCrunch identifier (RRID:SCR_008520, FlowJo)

SCR_002798https://scicrunch.org/resolver/SCR_002798 SciCrunch identifier (RRID:SCR_002798, GraphPad Prism)

SCR_010276https://scicrunch.org/resolver/SCR_010276 SciCrunch identifier (RRID:SCR_010276, HHpred)

SCR_005514https://scicrunch.org/resolver/SCR_005514 SciCrunch identifier (RRID:SCR_005514, HTSeq)

SCR_011867https://scicrunch.org/resolver/SCR_011867 SciCrunch identifier (RRID:SCR_011867, htseq-count)

SCR_014627https://scicrunch.org/resolver/SCR_014627 SciCrunch identifier (RRID:SCR_014627, I-TASSER)

SCR_016582https://scicrunch.org/resolver/SCR_016582 SciCrunch identifier (RRID:SCR_016582, kallisto)

SCR_013291https://scicrunch.org/resolver/SCR_013291 SciCrunch identifier (RRID:SCR_013291, MACS)

SCR_016620https://scicrunch.org/resolver/SCR_016620 SciCrunch identifier (RRID:SCR_016620, Metascape)

SCR_001905https://scicrunch.org/resolver/SCR_001905 SciCrunch identifier (RRID:SCR_001905, R Project for Statistical Computing)

SCR_018118https://scicrunch.org/resolver/SCR_018118 SciCrunch identifier (RRID:SCR_018118, RaptorX)

SCR_015899https://scicrunch.org/resolver/SCR_015899 SciCrunch identifier (RRID:SCR_015899, STAR)

static-c...SM.pdfhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41467-021-23327-1/MediaObjects/41467_2021_23327_MOESM1_ESM.pdf Supplemental material

static-c...SM.pdfhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41467-021-23327-1/MediaObjects/41467_2021_23327_MOESM4_ESM.pdf Supplemental material

goeseek.gwdguser.de/studies/149https://goeseek.gwdguser.de/studies/149 Supplemental material (goeseek study)

static-c...M.docxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41467-021-23327-1/MediaObjects/41467_2021_23327_MOESM2_ESM.docx Supplemental material (peer review)

static-c...SM.pdfhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41467-021-23327-1/MediaObjects/41467_2021_23327_MOESM3_ESM.pdf Supplemental material (reporting summary)

static-c...M.xlsxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41467-021-23327-1/MediaObjects/41467_2021_23327_MOESM11_ESM.xlsx Supplemental material (source data)

static-c...M.xlsxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41467-021-23327-1/MediaObjects/41467_2021_23327_MOESM5_ESM.xlsx Supplemental material (table)

static-c...M.xlsxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41467-021-23327-1/MediaObjects/41467_2021_23327_MOESM6_ESM.xlsx Supplemental material (table)

static-c...M.xlsxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41467-021-23327-1/MediaObjects/41467_2021_23327_MOESM7_ESM.xlsx Supplemental material (table)

static-c...M.xlsxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41467-021-23327-1/MediaObjects/41467_2021_23327_MOESM8_ESM.xlsx Supplemental material (table)

static-c...M.xlsxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41467-021-23327-1/MediaObjects/41467_2021_23327_MOESM9_ESM.xlsx Supplemental material (table)

static-c...M.xlsxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41467-021-23327-1/MediaObjects/41467_2021_23327_MOESM10_ESM.xlsx Supplemental material (table)

mbexc.de...ogy-2/https://mbexc.de/overarching-control-of-autophagy-and-dna-damage-response-by-chd6-revealed-by-modeling-a-rare-human-pathology-2/ Website entry (mbexc.de)

Q112310861https://www.wikidata.org/wiki/Q112310861 Wikidata ID

Linked Antibodies

PID	Type	Antigen symbol	Antibody Registry ID	Name
primary-0161	primary	ATG5	AB_2630393	Atg5 (D5F5U) antibody
primary-0603	primary	CHD6	AB_890573	CHD6 Antibody
primary-0604	primary	TFEB	AB_11204751	TFEB Antibody
primary-0605	primary	ATM	AB_10835213	Phospho-ATM (Ser1981) antibody
primary-0606	primary	ATR	AB_2290281	Phospho-ATR (Ser428) Antibody
primary-0607	primary	BRCA1	AB_491003	Phospho-BRCA1 (Ser1524) Antibody
primary-0608	primary	CHEK1	AB_331212	Phospho-Chk1 (Ser345) antibody
primary-0609	primary	H2AX	AB_2118009	Phospho-Histone H2A.X (Ser139) antibody
primary-0610	primary	CHEK2	AB_2080501	Phospho-Chk2 (Thr68) antibody
primary-0611	primary	TP53	AB_331741	Phospho-p53 (Ser15) antibody
primary-0612	primary	CBX5	AB_2614983	CBX5-human antibody
primary-0613	primary	H3K27me3	AB_2561020	Histone H3K27me3 antibody
primary-0614	primary	CHD6		Anti-CHD6 Antibody
primary-0615	primary		AB_10978021	HA Tag Monoclonal Antibody
primary-0616	primary	TUBB1	AB_477556	Anti-β-Tubulin antibody
primary-0617	primary	TAGLN	AB_443021	Anti-TAGLN/Transgelin antibody
primary-0618	primary	ATG12	AB_1903898	Atg12 (D88H11) antibody
primary-0619	primary	ATG7	AB_10831194	Atg7 (D12B11) antibody
primary-0620	primary	PARP1	AB_2160732	PARP-1 antibody
primary-0621	primary	MAP1LC3A / MAP1LC3B	AB_2617131	LC3A/B (D3U4C) XP® antibody
primary-0622	primary	NKX2-5	AB_355269	NKX2.5 Antibody
primary-0623	primary	NANOG	AB_355097	Nanog Antibody
primary-0624	primary	POU5F1	AB_628051	Anti-Oct-3/4 Antibody
primary-0625	primary	PAX3	AB_2722285	PAX3 Antibody
primary-0626	primary	CHD7	AB_869129	Anti-Chd7 antibody
primary-0627	primary	FOXD3	AB_1140692	Anti-FOXD3 antibody
primary-0628	primary	RPS6	AB_10694233	Phospho-S6 Ribosomal Protein (Ser240/244) (D68F8) XP® antibody
primary-0629	primary	MYH1E	AB_2147781	MF 20 antibody
primary-0630	primary	TUBB3	AB_444319	Anti-beta III Tubulin antibody
primary-0631	primary	SQSTM1	AB_2564787	Purified anti-p62 (SQSTM1) Antibody

Technical Support: menoci@medizin.uni-goettingen.de

Department of Medical Informatics
University Medical Center Göttingen
Imprint

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External Resources

Linked Antibodies

Technical support

Links

Spokesperson

Prof. Dr. Tobias Moser

Spokesperson of Cluster of Excellence