Technical Support: menoci@medizin.uni-goettingen.de
Department of Medical Informatics
University Medical Center Göttingen
Imprint
View primary antibody
Basic data
| PID | primary-0193 |
| EPIC PID | https://hdl.handle.net/21.11124/primary-0193 |
| Research group | RG Fernandez-Busnadiego |
| Quality (mean) | no score (0.00) |
| Sharing level | Public |
Antibody data
| Antigen symbol | VCP |
| Antibody Registry ID(s) | AB_298039 |
| Name | Anti-VCP antibody |
| Alternative name | |
| Lab ID | |
| Tag / Fluorophore | |
| Raised in | Mouse |
| Reacts with | mouse, rat, sheep, cow, human |
| Clone | 5 |
| Isotype | IgG2a |
| Clonality | monoclonal |
| Demasking | unknown |
| Antigen | Synthetic peptide corresponding to Human VCP aa 792-806. |
| Crafted By | company |
| Company / Manufacturer | Abcam |
| Catalog no. | ab11433 |
| Lot no. | GR3180147-3 |
| Description | Anti-VCP antibody [5] (ab11433) is not available anymore IHC-P (1) 1/500. IHC-Fr 1/500. Flow Cyt (1) 1/400. ELISA Use at an assay dependent concentration. ICC (1) Use at an assay dependent concentration. IP (3) Use at an assay dependent concentration. ICC/IF (5) 1/20 - 1/200. WB (13) 1/2000 |
| Localization | Cytoplasm > cytosol. Nucleus. |
| Storage instruction | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle. |
| Receipt date | 2021-03-20 00:00:00 |
| Preparation date | 2021-03-20 00:00:00 |
| Created by | Klauenberg, Vanessa |
| Last modified | Klauenberg, Vanessa |
External links
| Antibodypedia | - |
| HGNC | http://www.genenames.org/cgi-bin/gene_symbol_report?match=VCP |
| Wikipedia | http://en.wikipedia.org/wiki/VCP |
| Uniprot | http://www.uniprot.org/uniprot/?query=VCP |
| GeneCards | http://www.genecards.org/cgi-bin/carddisp.pl?gene=VCP |
| Antibody Registry | http://antibodyregistry.org/search?q=AB_298039 |
Applications
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Linked publications
Stress- and ubiquitylation-dependent phase separation of the proteasome
Yasuda S, Tsuchiya H, Kaiho A, Guo Q, Ikeuchi K, Endo A, Arai N, Ohtake F, Murata S, Inada T, Baumeister W, Fernández-Busnadiego R, Tanaka K, Saeki Y
Nature 2020 : 10.1038/s41586-020-1982-9
The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds
Saha I, Yuste-Checa P, Silva Padilha MD, Guo Q, Körner R, Holthusen H, Trinkaus VA, Dudanova I, Fernández-Busnadiego R, Baumeister W, Sanders DW, Gautam S, Diamond MI, Ulrich Hartl F, Hipp MS
bioRxiv 2022 : 10.1101/2022.02.18.481043
The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds in a cellular system
Saha I, Yuste-Checa P, Da Silva Padilha M, Guo Q, Körner R, Holthusen H, Trinkaus VA, Dudanova I, Fernández-Busnadiego R, Baumeister W, Sanders DW, Gautam S, Diamond MI, Hartl FU, Hipp MS
Nat Commun 2023 : 10.1038/s41467-023-36058-2
Autophagy preferentially degrades non-fibrillar polyQ aggregates
Zhao DY, Bäuerlein FJ, Saha I, Hartl FU, Baumeister W, Wilfling F
Mol Cell 2024 : 10.1016/j.molcel.2024.04.018
