Technical Support: menoci@medizin.uni-goettingen.de
Department of Medical Informatics
University Medical Center Göttingen
Imprint
View primary antibody
Basic data
| PID | primary-0368 |
| EPIC PID | https://hdl.handle.net/21.11124/primary-0368 |
| Research group | RG Fernandez-Busnadiego |
| Quality (mean) | no score (0.00) |
| Sharing level | Public |
Antibody data
| Antigen symbol | SNCA |
| Antibody Registry ID(s) | AB_398108 |
| Name | a-Synuclein antibody |
| Alternative name | non A4 component of amyloid precursor |
| Lab ID | |
| Tag / Fluorophore | |
| Raised in | Mouse |
| Reacts with | rat, human, mouse |
| Clone | 42 |
| Isotype | IgG1 |
| Clonality | monoclonal |
| Demasking | unknown |
| Antigen | Rat Synuclein-1 aa. 15-123 |
| Crafted By | company |
| Company / Manufacturer | BD Biosciences |
| Catalog no. | 610787 |
| Lot no. | |
| Description | Western blot (Routinely Tested) Immunofluorescence (Tested During Development) Immunohistochemistry (Reported) |
| Localization | |
| Storage instruction | Store undiluted at -20°C. |
| Receipt date | 2021-04-20 00:00:00 |
| Preparation date | 2021-04-20 00:00:00 |
| Created by | Klauenberg, Vanessa |
| Last modified | Klauenberg, Vanessa |
External links
| Antibodypedia | - |
| HGNC | http://www.genenames.org/cgi-bin/gene_symbol_report?match=SNCA |
| Wikipedia | http://en.wikipedia.org/wiki/SNCA |
| Uniprot | http://www.uniprot.org/uniprot/?query=SNCA |
| GeneCards | http://www.genecards.org/cgi-bin/carddisp.pl?gene=SNCA |
| Antibody Registry | http://antibodyregistry.org/search?q=AB_398108 |
Applications
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Linked publications
In situ architecture of neuronal α-Synuclein inclusions
Trinkaus VA, Riera-Tur I, Martínez-Sánchez A, Bäuerlein FJ, Guo Q, Arzberger T, Baumeister W, Dudanova I, Hipp MS, Hartl FU, Fernández-Busnadiego R
bioRxiv 2020 : 10.1101/2020.08.07.234138
Effects of pharmacological modulators of α-synuclein and tau aggregation and internalization
Dominguez-Meijide A, Vasili E, König A, Cima-Omori M, Ibáñez de Opakua A, Leonov A, Ryazanov S, Zweckstetter M, Griesinger C, Outeiro TF
Sci Rep 2020 : 10.1038/s41598-020-69744-y
Cofilin pathology is a new player on α-synuclein-induced spine impairment in models of hippocampal synucleinopathy
Oliveira da Silva MI, Santejo M, Babcock I, Magalhães A, Minamide L, Castillo E, Gerhardt E, Fahlbusch C, Swanson R, Outeiro T, Bamburg J, Liz M
bioRxiv 2021 : 10.1101/2021.02.02.425931
Cerebral Dopamine Neurotrophic Factor Reduces α-Synuclein Aggregation and Propagation and Alleviates Behavioural Alterations in vivo
Albert K, Raymundo DP, Panhelainen A, Eesmaa A, Shvachiy L, Araújo GR, Chmielarz P, Yan X, Singh A, Cordeiro Y, Palhano FL, Foguel D, Luk KC, Domanskyi A, Voutilainen MH, Huttunen HJ, Outeiro TF, Saarma M, Almeida MS, Airavaara M
Mol Ther 2021 : 10.1016/j.ymthe.2021.04.035
α‐Synuclein in Plasma‐Derived Extracellular Vesicles Is a Potential Biomarker of Parkinson's Disease
Stuendl A, Kraus T, Chatterjee M, Zapke B, Sadowski B, Moebius W, Hobert MA, Deuschle C, Brockmann K, Maetzler W, Mollenhauer B, Schneider A
Mov Disord 2021 : 10.1002/mds.28639
In situ architecture of neuronal α-Synuclein inclusions
Trinkaus VA, Riera-Tur I, Martínez-Sánchez A, Bäuerlein FJB, Guo Q, Arzberger T, Baumeister W, Dudanova I, Hipp MS, Hartl FU, Fernández-Busnadiego R
Nat Commun 2021 : 10.1038/s41467-021-22108-0
Common molecular mechanisms underlie the transfer of alpha-synuclein, Tau and huntingtin and modulate spontaneous activity in neuronal cells
Brás IC, Khani MH, Vasili E, Möbius W, Riedel D, Parfentev I, Gerhardt E, Fahlbusch C, Urlaub H, Zweckstetter M, Gollisch T, Outeiro TF
bioRxiv 2021 : 10.1101/2021.07.18.452825
Monitoring Alpha-Synuclein – Tau Interactions In Vitro and In Vivo Using Bimolecular Fluorescence Complementation
Torres-Garcia L, Domingues JM, Brandi E, Haikal C, Brás IC, Gerhardt E, Li W, Svanbergsson A, Outeiro TF, Gouras GK, Li J
Researchsquare 2021 : 10.21203/rs.3.rs-960446/v1
Monitoring the interactions between alpha-synuclein and Tau in vitro and in vivo using bimolecular fluorescence complementation
Torres-Garcia L, P. Domingues JM, Brandi E, Haikal C, Mudannayake JM, Brás IC, Gerhardt E, Li W, Svanbergsson A, Outeiro TF, Gouras GK, Li J
Sci Rep 2022 : 10.1038/s41598-022-06846-9
Nuclear alpha-synuclein is present in the human brain and is modified in dementia with Lewy bodies
Koss DJ, Erskine D, Porter A, Palmoski P, Leite M, Attems J, Outeiro TF
bioRxiv 2021 : 10.1101/2021.10.20.465125
Aromaticity at position 39 in α‐synuclein: A modulator of amyloid fibril assembly and membrane‐bound conformations
Buratti FA, Boeffinger N, Garro HA, Flores JS, Hita FJ, Gonçalves PdC, Copello FdR, Lizarraga L, Rossetti G, Carloni P, Zweckstetter M, Outeiro TF, Eimer S, Griesinger C, Fernández CO
Protein Sci 2022 : 10.1002/pro.4360
JM-20, a Benzodiazepine-Dihydropyridine Hybrid Molecule, Inhibits the Formation of Alpha-Synuclein-Aggregated Species
Santos CC, Cardim-Pires TR, Shvachiy L, Fonseca-Fonseca LA, Muñoz P, Almeida AMAN, Costa ACS, Teles-Souza J, Ochoa-Rodríguez E, de Fátima Dias Costa M, Palhano FL, Segura-Aguilar J, Barbosa DB, do Bomfim MR, dos Santos Junior MC, Leite FHA, da Rocha Pita SS, Costa S, Núñez-Figueredo Y, Outeiro TF, Foguel D, Silva VDA
Neurotox Res 2022 : 10.1007/s12640-022-00559-7
Changes in α-Synuclein Posttranslational Modifications in an AAV-Based Mouse Model of Parkinson’s Disease
Brembati V, Faustini G, Longhena F, Outeiro TF, Bellucci A
Int J Mol Sci 2023 : 10.3390/ijms241713435
α-Synuclein triggers cofilin pathology and dendritic spine impairment via a PrPC-CCR5 dependent pathway
Oliveira da Silva MI, Santejo M, Babcock IW, Magalhães A, Minamide LS, Won S, Castillo E, Gerhardt E, Fahlbusch C, Swanson RA, Outeiro TF, Taipa R, Ruff M, Bamburg JR, Liz MA
Cell Death Dis 2024 : 10.1038/s41419-024-06630-9
Lead as a toxic environmental toxicant in models of synucleinopathies
Shvachiy L, Amaro-Leal Â, Machado F, Rocha I, Geraldes V, Outeiro TF
bioRxiv 2024 : 10.1101/2024.10.10.617554
