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Publication
Property Value
Working Groups RG Fernandez-Busnadiego
Subproject RA2.1
Open Access Open Access  Yes
Publication Type Preprint
Peer Reviewed No
DOI DOI  10.1101/2022.02.18.481043
Publication Year 2022
Title The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds
Journal bioRxiv
eISSN 2692-8205
URL  http://dx.doi.org/10.1101/2022.02.18.481043
Journal Abbreviation bioRxiv
Extra Final article published in Nature Communications here: doi:10.1038/s41467-023-36058-2
Authors Saha I, Yuste-Checa P, Silva Padilha MD, Guo Q, Körner R, Holthusen H, Trinkaus VA, Dudanova I, Fernández-Busnadiego R, Baumeister W, Sanders DW, Gautam S, Diamond MI, Ulrich Hartl F, Hipp MS
First Author Saha I
Last Author Hipp MS

 External Resources

 12259 Addgene identifier (12259, reused)

 12260 Addgene identifier (12260, reused)

 23971 Addgene identifier (23971, reused)

 23972 Addgene identifier (23972, reused)

 23973 Addgene identifier (23973, reused)

 23974 Addgene identifier (23974, reused)

 100521 Addgene identifier (100521, reused)

 biorxiv....ll.pdf Article fulltext

 2/106453 GRO.publications identifier

 0000-0002-0289-4082 ORCID identifier (Itika Saha)

 0000-0002-1056-3849 ORCID identifier (Patricia Yuste Checa)

 0000-0003-3520-5439 ORCID identifier (Qiang Guo)

 0000-0002-2050-413X ORCID identifier (Hauke Holthusen)

 0000-0001-8964-6120 ORCID identifier (Victoria Anne Trinkaus)

 0000-0003-1052-8485 ORCID identifier (Irina Dudanova)

 0000-0002-8366-7622 ORCID identifier (Ruben Fernandez-Busnadiego)

 0000-0002-7941-135X ORCID identifier (F. Ulrich Hartl)

 0000-0002-0497-3016 ORCID identifier (Mark S. Hipp)

 654 Published Data Registry entry (MBExC, final article)

 1/300 Research Data Archive (supplemental material)

 03zj4c476 ROR identifier (03zj4c476, Aligning Science Across Parkinson's)

 033n9gh91 ROR identifier (033n9gh91, Carl von Ossietzky Universität Oldenburg)

 04py35477 ROR identifier (04py35477, Max Planck Institute of Biochemistry)

 03ap2av50 ROR identifier (03ap2av50, Max Planck Institute of Neurobiology)

 025z3z560 ROR identifier (025z3z560, Munich Cluster for Systems Neurology)

 05xy1nn52 ROR identifier (05xy1nn52, Multiscale Bioimaging)

 05byvp690 ROR identifier (05byvp690, The University of Texas Southwestern Medical Center)

 021ft0n22 ROR identifier (021ft0n22, University Medical Center Göttingen)

 01y9bpm73 ROR identifier (01y9bpm73, University of Göttingen)

 012p63287 ROR identifier (012p63287, University of Groningen)

 SCR_007353 SciCrunch identifier (RRID:SCR_007353, Advanced 3D Visualization and Volume Modeling)

 SCR_002285 SciCrunch identifier (RRID:SCR_002285, Fiji)

 SCR_008520 SciCrunch identifier (RRID:SCR_008520, FlowJo)

 SCR_002798 SciCrunch identifier (RRID:SCR_002798, GraphPad Prism)

 SCR_003070 SciCrunch identifier (RRID:SCR_003070, ImageJ)

 SCR_003297 SciCrunch identifier (RRID:SCR_003297, IMOD)

 SCR_014485 SciCrunch identifier (RRID:SCR_014485, MaxQuant)

 SCR_016499 SciCrunch identifier (RRID:SCR_016499, MotionCor 2)

 SCR_015753 SciCrunch identifier (RRID:SCR_015753, Perseus)

 SCR_017293 SciCrunch identifier (RRID:SCR_017293, SerialEM)

 SCR_013672 SciCrunch identifier (RRID:SCR_013672, ZEN Digital Imaging for Light Microscopy)

 biorxiv....d=true Supplemental material

 mbexc.de...seeds/ Website entry (mbexc.de)

Linked Antibodies

PID AG Type Antigen symbol Antibody Registry ID Name
primary-0008 primary GAPDH AB_2107445 Anti-Glyceraldehyde-3-Phosphate Dehydrogenase Antibody
primary-0111 primary TUBA4A AB_477583 Anti-α-Tubulin antibody
primary-0185 primary MAPT AB_223647 Phospho-Tau (Ser202, Thr205) Monoclonal Antibody
primary-0190 primary UBB AB_1587578 Anti-Ubiquitin Antibody
primary-0193 primary VCP AB_298039 Anti-VCP antibody
primary-0619 primary ATG7 AB_10831194 Atg7 (D12B11) antibody
primary-0784 primary GFP AB_390913 Anti-GFP antibody
primary-0988 primary VCP AB_2304347 p97/VCP Antibody
primary-0989 primary UBB AB_2895239 Recombinant Anti-Ubiquitin (linkage-specific K63) antibody [EPR8590-448]
primary-0990 primary UBB AB_628423 Anti-Ubiquitin Antibody (P4D1)
primary-0991 primary MAPT AB_11167058 Tau (phospho Ser356) antibody
primary-0992 primary NPLOC4 AB_1854586 Anti-NPLOC4 antibody
primary-0993 primary UFD1 AB_10678868 Anti-UFD1L antibody
primary-0994 primary Ubiquitinylated proteins AB_612093 Anti-Ubiquitinylated proteins Antibody
primary-0995 primary MAPT AB_10980631 Tau Monoclonal Antibody
primary-0996 primary MAPT AB_2341273 Anti-Human Tau/Repeat Domain (2B11) Mouse IgG MoAb
primary-0997 primary MAP1LC3B AB_796155 Anti-LC3B antibody
primary-0998 primary ATG5 AB_2062340 Atg5 Antibody
primary-0999 primary PSMD11 AB_2268979 PSMD11 Polyclonal antibody
secondary-0042 secondary AB_2534033 Goat anti-Mouse IgG (H+L) Cross-Adsorbed Secondary Antibody, Cyanine5
secondary-0376 secondary AB_258434 Anti-Rabbit IgG (whole molecule)–Peroxidase antibody
secondary-1000 secondary AB_2534032 Goat anti-Rabbit IgG (H+L) Cross-Adsorbed Secondary Antibody, Cyanine5
secondary-1001 secondary AB_2340863 Alexa Fluor® 647 AffiniPure Donkey Anti-Mouse IgG (H+L)
secondary-1002 secondary AB_2556746 Donkey anti-Mouse IgG (H+L) Cross-Adsorbed Secondary Antibody, DyLight 488
secondary-1003 secondary AB_258167 Anti-Mouse IgG (whole molecule)–Peroxidase antibody
secondary-1004 secondary AB_10956588 IRDye® 680RD Goat anti-Mouse IgG Secondary Antibody
secondary-1005 secondary AB_621843 IRDye® 800CW Goat anti-Rabbit IgG Secondary Antibody