| Property |
Value |
| Working Groups |
RG Wollnik |
| Subproject |
RA1.2 |
| Open Access |
Yes |
| Publication Type |
Journal Article |
| Peer Reviewed |
Yes |
| PMID |
34021162 |
| DOI |
10.1038/s41467-021-23327-1 |
| Publication Year |
2021 |
| Title |
Overarching control of autophagy and DNA damage response by CHD6 revealed by modeling a rare human pathology |
| Journal |
Nature Communications |
| ISSN |
2041-1723 |
| eISSN |
2041-1723 |
| URL |
http://dx.doi.org/10.1038/s41467-021-23327-1 |
| Issue |
1 |
| Volume |
12 |
| Journal Abbreviation |
Nat Commun |
| Authors |
Kargapolova Y, Rehimi R, Kayserili H, Brühl J, Sofiadis K, Zirkel A, Palikyras S, Mizi A, Li Y, Yigit G, Hoischen A, Frank S, Russ N, Trautwein J, van Bon B, Gilissen C, Laugsch M, Gusmao EG, Josipovic N, Altmüller J, Nürnberg P, Längst G, Kaiser FJ, Watrin E, Brunner H, Rada-Iglesias A, Kurian L, Wollnik B, Bouazoune K, Papantonis A |
| First Author |
Kargapolova Y |
| Last Author |
Papantonis A |
External Resources
nature.c...-1.pdfhttps://www.nature.com/articles/s41467-021-23327-1.pdf Article fulltext
2/86739https://publications.goettingen-research-online.de/handle/2/86739 GRO.publications identifier
GSE135832https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE135832 NCBI GEO Dataset (GSE135832)
GSE136057https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE136057 NCBI GEO Dataset (GSE136057)
GSE29611https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE29611 NCBI GEO Dataset (GSE29611, reused)
GSE31477https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE31477 NCBI GEO Dataset (GSE31477, reused)
GSE32970https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE32970 NCBI GEO Dataset (GSE32970, reused)
GSE35239https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE35239 NCBI GEO Dataset (GSE35239, reused)
GSE124903https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE124903 NCBI GEO Dataset (GSE124903, reused)
GSE128351https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE128351 NCBI GEO Dataset (GSE128351, reused)
9606https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 NCBI taxonomy (human, Homo sapiens)
234100https://www.omim.org/entry/234100 OMIM identifier (234100, HSS)
0000-0003-2589-0364https://orcid.org/0000-0003-2589-0364 ORCID identifier (Bernd Wollnik)
PXD024803http://proteomecentral.proteomexchange.org/cgi/GetDataset?ID=PXD024803 Pride proteome dataset (PXD024803)
8https://prod.mbexc.uni-goettingen.de/literature/publications/8 Published Data Registry entry (MBExC, preprint)
1/402https://mbexc.uni-goettingen.de/archive/1/402 Research Data Archive (supplemental material)
04c4bwh63https://ror.org/04c4bwh63 ROR identifier (04c4bwh63, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases)
02na8dn90https://ror.org/02na8dn90 ROR identifier (02na8dn90, Essen University Hospital)
038t36y30https://ror.org/038t36y30 ROR identifier (038t36y30, Heidelberg University)
036xhtv26https://ror.org/036xhtv26 ROR identifier (036xhtv26, Institut de génétique et de développement de Rennes)
00jzwgz36https://ror.org/00jzwgz36 ROR identifier (00jzwgz36, Koç University)
05xy1nn52https://ror.org/05xy1nn52 ROR identifier (05xy1nn52, Multiscale Bioimaging)
01rdrb571https://ror.org/01rdrb571 ROR identifier (01rdrb571, Philipps University of Marburg)
05wg1m734https://ror.org/05wg1m734 ROR identifier (05wg1m734, Radboud University Nijmegen Medical Centre)
046ffzj20https://ror.org/046ffzj20 ROR identifier (046ffzj20, Universidad de Cantabria)
05mxhda18https://ror.org/05mxhda18 ROR identifier (05mxhda18, University Hospital Cologne)
021ft0n22https://ror.org/021ft0n22 ROR identifier (021ft0n22, University Medical Center Göttingen)
01eezs655https://ror.org/01eezs655 ROR identifier (01eezs655, University of Regensburg)
SCR_006442https://scicrunch.org/resolver/SCR_006442 SciCrunch identifier (RRID:SCR_006442, Bioconductor)
SCR_005476https://scicrunch.org/resolver/SCR_005476 SciCrunch identifier (RRID:SCR_005476, Bowtie)
SCR_015626https://scicrunch.org/resolver/SCR_015626 SciCrunch identifier (RRID:SCR_015626, ChAS)
SCR_015687https://scicrunch.org/resolver/SCR_015687 SciCrunch identifier (RRID:SCR_015687, DESeq2)
SCR_002285https://scicrunch.org/resolver/SCR_002285 SciCrunch identifier (RRID:SCR_002285, Fiji)
SCR_008520https://scicrunch.org/resolver/SCR_008520 SciCrunch identifier (RRID:SCR_008520, FlowJo)
SCR_002798https://scicrunch.org/resolver/SCR_002798 SciCrunch identifier (RRID:SCR_002798, GraphPad Prism)
SCR_010276https://scicrunch.org/resolver/SCR_010276 SciCrunch identifier (RRID:SCR_010276, HHpred)
SCR_005514https://scicrunch.org/resolver/SCR_005514 SciCrunch identifier (RRID:SCR_005514, HTSeq)
SCR_011867https://scicrunch.org/resolver/SCR_011867 SciCrunch identifier (RRID:SCR_011867, htseq-count)
SCR_014627https://scicrunch.org/resolver/SCR_014627 SciCrunch identifier (RRID:SCR_014627, I-TASSER)
SCR_016582https://scicrunch.org/resolver/SCR_016582 SciCrunch identifier (RRID:SCR_016582, kallisto)
SCR_013291https://scicrunch.org/resolver/SCR_013291 SciCrunch identifier (RRID:SCR_013291, MACS)
SCR_016620https://scicrunch.org/resolver/SCR_016620 SciCrunch identifier (RRID:SCR_016620, Metascape)
SCR_001905https://scicrunch.org/resolver/SCR_001905 SciCrunch identifier (RRID:SCR_001905, R Project for Statistical Computing)
SCR_018118https://scicrunch.org/resolver/SCR_018118 SciCrunch identifier (RRID:SCR_018118, RaptorX)
SCR_015899https://scicrunch.org/resolver/SCR_015899 SciCrunch identifier (RRID:SCR_015899, STAR)
static-c...SM.pdfhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41467-021-23327-1/MediaObjects/41467_2021_23327_MOESM1_ESM.pdf Supplemental material
static-c...SM.pdfhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41467-021-23327-1/MediaObjects/41467_2021_23327_MOESM4_ESM.pdf Supplemental material
goeseek.gwdguser.de/studies/149https://goeseek.gwdguser.de/studies/149 Supplemental material (goeseek study)
static-c...M.docxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41467-021-23327-1/MediaObjects/41467_2021_23327_MOESM2_ESM.docx Supplemental material (peer review)
static-c...SM.pdfhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41467-021-23327-1/MediaObjects/41467_2021_23327_MOESM3_ESM.pdf Supplemental material (reporting summary)
static-c...M.xlsxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41467-021-23327-1/MediaObjects/41467_2021_23327_MOESM11_ESM.xlsx Supplemental material (source data)
static-c...M.xlsxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41467-021-23327-1/MediaObjects/41467_2021_23327_MOESM5_ESM.xlsx Supplemental material (table)
static-c...M.xlsxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41467-021-23327-1/MediaObjects/41467_2021_23327_MOESM6_ESM.xlsx Supplemental material (table)
static-c...M.xlsxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41467-021-23327-1/MediaObjects/41467_2021_23327_MOESM7_ESM.xlsx Supplemental material (table)
static-c...M.xlsxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41467-021-23327-1/MediaObjects/41467_2021_23327_MOESM8_ESM.xlsx Supplemental material (table)
static-c...M.xlsxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41467-021-23327-1/MediaObjects/41467_2021_23327_MOESM9_ESM.xlsx Supplemental material (table)
static-c...M.xlsxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41467-021-23327-1/MediaObjects/41467_2021_23327_MOESM10_ESM.xlsx Supplemental material (table)
mbexc.de...ogy-2/https://mbexc.de/overarching-control-of-autophagy-and-dna-damage-response-by-chd6-revealed-by-modeling-a-rare-human-pathology-2/ Website entry (mbexc.de)
Q112310861https://www.wikidata.org/wiki/Q112310861 Wikidata ID
Linked Antibodies
| PID |
AG |
Type |
Antigen symbol |
Antibody Registry ID |
Name |
| primary-0161 |
 |
primary |
ATG5 |
AB_2630393 |
Atg5 (D5F5U) antibody |
| primary-0603 |
|
primary |
CHD6 |
AB_890573 |
CHD6 Antibody |
| primary-0604 |
|
primary |
TFEB |
AB_11204751 |
TFEB Antibody |
| primary-0605 |
|
primary |
ATM |
AB_10835213 |
Phospho-ATM (Ser1981) antibody |
| primary-0606 |
|
primary |
ATR |
AB_2290281 |
Phospho-ATR (Ser428) Antibody |
| primary-0607 |
|
primary |
BRCA1 |
AB_491003 |
Phospho-BRCA1 (Ser1524) Antibody |
| primary-0608 |
|
primary |
CHEK1 |
AB_331212 |
Phospho-Chk1 (Ser345) antibody |
| primary-0609 |
|
primary |
H2AX |
AB_2118009 |
Phospho-Histone H2A.X (Ser139) antibody |
| primary-0610 |
|
primary |
CHEK2 |
AB_2080501 |
Phospho-Chk2 (Thr68) antibody |
| primary-0611 |
|
primary |
TP53 |
AB_331741 |
Phospho-p53 (Ser15) antibody |
| primary-0612 |
|
primary |
CBX5 |
AB_2614983 |
CBX5-human antibody |
| primary-0613 |
|
primary |
H3K27me3 |
AB_2561020 |
Histone H3K27me3 antibody |
| primary-0614 |
|
primary |
CHD6 |
|
Anti-CHD6 Antibody |
| primary-0615 |
|
primary |
|
AB_10978021 |
HA Tag Monoclonal Antibody |
| primary-0616 |
|
primary |
TUBB1 |
AB_477556 |
Anti-β-Tubulin antibody |
| primary-0617 |
|
primary |
TAGLN |
AB_443021 |
Anti-TAGLN/Transgelin antibody |
| primary-0618 |
|
primary |
ATG12 |
AB_1903898 |
Atg12 (D88H11) antibody |
| primary-0619 |
|
primary |
ATG7 |
AB_10831194 |
Atg7 (D12B11) antibody |
| primary-0620 |
|
primary |
PARP1 |
AB_2160732 |
PARP-1 antibody |
| primary-0621 |
|
primary |
MAP1LC3A / MAP1LC3B |
AB_2617131 |
LC3A/B (D3U4C) XP® antibody |
| primary-0622 |
|
primary |
NKX2-5 |
AB_355269 |
NKX2.5 Antibody |
| primary-0623 |
|
primary |
NANOG |
AB_355097 |
Nanog Antibody |
| primary-0624 |
|
primary |
POU5F1 |
AB_628051 |
Anti-Oct-3/4 Antibody |
| primary-0625 |
|
primary |
PAX3 |
AB_2722285 |
PAX3 Antibody |
| primary-0626 |
|
primary |
CHD7 |
AB_869129 |
Anti-Chd7 antibody |
| primary-0627 |
|
primary |
FOXD3 |
AB_1140692 |
Anti-FOXD3 antibody |
| primary-0628 |
|
primary |
RPS6 |
AB_10694233 |
Phospho-S6 Ribosomal Protein (Ser240/244) (D68F8) XP® antibody |
| primary-0629 |
|
primary |
MYH1E |
AB_2147781 |
MF 20 antibody |
| primary-0630 |
|
primary |
TUBB3 |
AB_444319 |
Anti-beta III Tubulin antibody |
| primary-0631 |
|
primary |
SQSTM1 |
AB_2564787 |
Purified anti-p62 (SQSTM1) Antibody |