Technical Support: menoci@medizin.uni-goettingen.de
Department of Medical Informatics
University Medical Center Göttingen
Imprint
View primary antibody
Basic data
| PID | primary-0787 |
| EPIC PID | https://hdl.handle.net/21.11124/primary-0787 |
| Research group | RG Gollisch |
| Quality (mean) | no score (0.00) |
| Sharing level | Public |
Antibody data
| Antigen symbol | SQSTM1 |
| Antibody Registry ID(s) | AB_2050336 |
| Name | Anti-SQSTM1 / p62 antibody |
| Alternative name | autophagy receptor p62 |
| Lab ID | |
| Tag / Fluorophore | |
| Raised in | Rabbit |
| Reacts with | Mouse, Rat, Human |
| Clone | |
| Isotype | IgG |
| Clonality | polyclonal |
| Demasking | unknown |
| Antigen | Synthetic peptide corresponding to Human SQSTM1/ p62 (C terminal). |
| Crafted By | company |
| Company / Manufacturer | Abcam |
| Catalog no. | ab91526 |
| Lot no. | |
| Description | ICC/IF Use at an assay dependent concentration. WB Use a concentration of 0.5 - 2 µg/ml. Detects a band of approximately 65 kDa (predicted molecular weight: 47 kDa). Only mouse and human species are validated in WB. Rat is not a validated species. IHC-P Use a concentration of 2 - 5 µg/ml. |
| Localization | Cytoplasm. Late endosome. Nucleus. Sarcomere (By similarity). In cardiac muscles localizes to the sarcomeric band (By similarity). Localizes to late endosomes. May also localize to the nucleus. Accumulates in neurofibrillary tangles and in Lewy bodies of neurons from individuals with Alzheimer and Parkinson disease respectively. Enriched in Rosenthal fibers of pilocytic astrocytoma. In liver cells, accumulates in Mallory bodies associated with alcoholic hepatitis, Wilson disease, indian childhood cirrhosis and in hyaline bodies associated with hepatocellular carcinoma. |
| Storage instruction | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C. Avoid freeze / thaw cycle. |
| Receipt date | 2021-10-04 00:00:00 |
| Preparation date | 2021-10-04 00:00:00 |
| Created by | Klauenberg, Vanessa |
| Last modified | Klauenberg, Vanessa |
External links
| Antibodypedia | - |
| HGNC | http://www.genenames.org/cgi-bin/gene_symbol_report?match=SQSTM1 |
| Wikipedia | http://en.wikipedia.org/wiki/SQSTM1 |
| Uniprot | http://www.uniprot.org/uniprot/?query=SQSTM1 |
| GeneCards | http://www.genecards.org/cgi-bin/carddisp.pl?gene=SQSTM1 |
| Antibody Registry | http://antibodyregistry.org/search?q=AB_2050336 |
Applications
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Linked publications
Common molecular mechanisms underlie the transfer of alpha-synuclein, Tau and huntingtin and modulate spontaneous activity in neuronal cells
Brás IC, Khani MH, Vasili E, Möbius W, Riedel D, Parfentev I, Gerhardt E, Fahlbusch C, Urlaub H, Zweckstetter M, Gollisch T, Outeiro TF
bioRxiv 2021 : 10.1101/2021.07.18.452825
