Technical Support: menoci@medizin.uni-goettingen.de
Department of Medical Informatics
University Medical Center Göttingen
Imprint
View primary antibody
Basic data
| PID | primary-1544 |
| EPIC PID | https://hdl.handle.net/21.11124/primary-1544 |
| Research group | RG Bähr |
| Quality (mean) | no score (0.00) |
| Sharing level | Public |
Antibody data
| Antigen symbol | MAPT |
| Antibody Registry ID(s) | AB_11212693 |
| Name | Anti-Tau (3-repeat isoform RD3) Antibody, clone 8E6/C11 |
| Alternative name | |
| Lab ID | |
| Tag / Fluorophore | |
| Raised in | mouse |
| Reacts with | human |
| Clone | 8E6/C11 |
| Isotype | |
| Clonality | monoclonal |
| Demasking | unknown |
| Antigen | |
| Crafted By | company |
| Company / Manufacturer | Merck (Sigma-Aldrich) |
| Catalog no. | 05-803 |
| Lot no. | |
| Description | Second entry at https://www.antibodyregistry.org/: AB_310013. Immunogen: Bovine thyroglobulin conjugated synthetic peptide corresponding to amino acids 209-224 (KHQPGGGKVQIVYKPV) of human Tau (isoform RD3). In other isoforms of huTau this sequence spans amino acids 267-316, omitting the second repeat domain where it bridges RD1 and RD3. The immunizing sequence is identical in human, mouse and bovine. |
| Localization | |
| Storage instruction | Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variabillity in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. |
| Receipt date | 2024-07-01 00:00:00 |
| Preparation date | 2024-07-01 00:00:00 |
| Created by | , |
| Last modified | , |
External links
| Antibodypedia | - |
| HGNC | http://www.genenames.org/cgi-bin/gene_symbol_report?match=MAPT |
| Wikipedia | http://en.wikipedia.org/wiki/MAPT |
| Uniprot | http://www.uniprot.org/uniprot/?query=MAPT |
| GeneCards | http://www.genecards.org/cgi-bin/carddisp.pl?gene=MAPT |
| Antibody Registry | http://antibodyregistry.org/search?q=AB_11212693 |
Applications
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Linked publications
Plasma extracellular vesicle tau and TDP-43 as diagnostic biomarkers in FTD and ALS
Chatterjee M, Özdemir S, Fritz C, Möbius W, Kleineidam L, Mandelkow E, Biernat J, Doğdu C, Peters O, Cosma NC, Wang X, Schneider LS, Priller J, Spruth E, Kühn AA, Krause P, Klockgether T, Vogt IR, Kimmich O, Spottke A, Hoffmann DC, Fliessbach K, Miklitz C, McCormick C, Weydt P, Falkenburger B, Brandt M, Guenther R, Dinter E, Wiltfang J, Hansen N, Bähr M, Zerr I, Flöel A, Nestor PJ, Düzel E, Glanz W, Incesoy E, Bürger K, Janowitz D, Perneczky R, Rauchmann BS, Hopfner F, Wagemann O, Levin J, Teipel S, Kilimann I, Goerss D, Prudlo J, Gasser T, Brockmann K, Mengel D, Zimmermann M, Synofzik M, Wilke C, Selma-González J, Turon-Sans J, Santos-Santos MA, Alcolea D, Rubio-Guerra S, Fortea J, Carbayo Á, Lleó A, Rojas-García R, Illán-Gala I, Wagner M, Frommann I, Roeske S, Bertram L, Heneka MT, Brosseron F, Ramirez A, Schmid M, Beschorner R, Halle A, Herms J, Neumann M, Barthélemy NR, Bateman RJ, Rizzu P, Heutink P, Dols-Icardo O, Höglinger G, Hermann A, Schneider A
Nat Med 2024 : 10.1038/s41591-024-02937-4
