Technical Support: menoci@medizin.uni-goettingen.de
Department of Medical Informatics
University Medical Center Göttingen
Imprint
View primary antibody
Basic data
| PID | primary-0883 |
| EPIC PID | https://hdl.handle.net/21.11124/primary-0883 |
| Research group | RG Outeiro |
| Quality (mean) | no score (0.00) |
| Sharing level | Public |
Antibody data
| Antigen symbol | SQSTM1 |
| Antibody Registry ID(s) | AB_2885112 |
| Name | Recombinant Anti-SQSTM1 / p62 antibody [EPR18351] |
| Alternative name | p62 |
| Lab ID | |
| Tag / Fluorophore | |
| Raised in | Rabbit |
| Reacts with | Human |
| Clone | EPR18351 |
| Isotype | IgG |
| Clonality | monoclonal |
| Demasking | unknown |
| Antigen | Recombinant full length protein. This information is proprietary to Abcam and/or its suppliers. |
| Crafted By | company |
| Company / Manufacturer | Abcam |
| Catalog no. | ab207305 |
| Lot no. | |
| Description | Flow Cyt (Intra) 1/100. ab172730 - Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody. IHC-P 1/2000. Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol. WB 1/1000. Detects a band of approximately 62 kDa (predicted molecular weight: 47 kDa). ICC/IF Use a concentration of 1 µg/ml. IP 1/40. |
| Localization | Cytoplasm. Late endosome. Nucleus. Sarcomere (By similarity). In cardiac muscles localizes to the sarcomeric band (By similarity). Localizes to late endosomes. May also localize to the nucleus. Accumulates in neurofibrillary tangles and in Lewy bodies of neurons from individuals with Alzheimer and Parkinson disease respectively. Enriched in Rosenthal fibers of pilocytic astrocytoma. In liver cells, accumulates in Mallory bodies associated with alcoholic hepatitis, Wilson disease, indian childhood cirrhosis and in hyaline bodies associated with hepatocellular carcinoma. |
| Storage instruction | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. |
| Receipt date | 2022-01-13 00:00:00 |
| Preparation date | 2022-01-13 00:00:00 |
| Created by | Klauenberg, Vanessa |
| Last modified | Klauenberg, Vanessa |
External links
| Antibodypedia | - |
| HGNC | http://www.genenames.org/cgi-bin/gene_symbol_report?match=SQSTM1 |
| Wikipedia | http://en.wikipedia.org/wiki/SQSTM1 |
| Uniprot | http://www.uniprot.org/uniprot/?query=SQSTM1 |
| GeneCards | http://www.genecards.org/cgi-bin/carddisp.pl?gene=SQSTM1 |
| Antibody Registry | http://antibodyregistry.org/search?q=AB_2885112 |
Applications
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Linked publications
Prion-like α-synuclein pathology in the brain of infants with Krabbe disease
Hatton C, Ghanem SS, Koss DJ, Abdi IY, Gibbons E, Guerreiro R, Bras J, Walker L, Gelpi E, Heywood W, Outeiro TF, Attems J, McFarland R, Forsyth R, El-Agnaf OM, Erskine D
Brain 2022 : 10.1093/brain/awac002
