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Property	Value
Working Groups	RG Cramer, RG Urlaub
Subproject	None
Open Access	Yes
Publication Type	Journal Article
Peer Reviewed	Yes
PMID	38821049
DOI	10.1016/j.molcel.2024.05.007
Publication Year	2024
Title	CDK7 kinase activity promotes RNA polymerase II promoter escape by facilitating initiation factor release
Journal	Molecular Cell
ISSN	1097-2765
eISSN	1097-4164
URL	http://dx.doi.org/10.1016/j.molcel.2024.05.007
Journal Abbreviation	Mol Cell
Authors	Velychko T, Mohammad E, Ferrer-Vicens I, Parfentev I, Werner M, Studniarek C, Schwalb B, Urlaub H, Murphy S, Cramer P, Lidschreiber M
First Author	Velychko T
Last Author	Lidschreiber M

 External Resources

 cell.com...0400-3https://www.cell.com/molecular-cell/pdfExtended/S1097-2765(24)00400-3 Article fulltext

 2/144112http://resolver.sub.uni-goettingen.de/purl?2/144112 GRO.publications identifier

 GSE218269https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE218269 NCBI GEO Dataset (GSE218269)

 GSE133156https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE133156 NCBI GEO Dataset (GSE133156, reused)

 9606https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 NCBI taxonomy (human, Homo sapiens)

 7227https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=7227 NCBI taxonomy (fruit fly, Drosophila melanogaster)

 1247190https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=1247190 NCBI taxonomy (yeast, Saccharomyces cerevisiae BY4741)

 0000-0003-4087-3730https://orcid.org/0000-0003-4087-3730 ORCID identifier (Taras Velychko)

 0009-0003-8951-1463https://orcid.org/0009-0003-8951-1463 ORCID identifier (Eusra Mohammad)

 0000-0002-3553-0488https://orcid.org/0000-0002-3553-0488 ORCID identifier (Ivan Ferrer-Vicens)

 0000-0002-0203-2167https://orcid.org/0000-0002-0203-2167 ORCID identifier (Iwan Parfentev)

 0000-0002-6328-048Xhttps://orcid.org/0000-0002-6328-048X ORCID identifier (Marcel Werner)

 0000-0003-0889-9949https://orcid.org/0000-0003-0889-9949 ORCID identifier (Cecilia Studniarek)

 0000-0003-2987-2622https://orcid.org/0000-0003-2987-2622 ORCID identifier (Björn Schwalb)

 0000-0003-1837-5233https://orcid.org/0000-0003-1837-5233 ORCID identifier (Henning Urlaub)

 0000-0001-5454-7755https://orcid.org/0000-0001-5454-7755 ORCID identifier (Patrick Cramer)

 PXD037842http://proteomecentral.proteomexchange.org/cgi/GetDataset?ID=PXD037842 Pride proteome dataset (PXD037842)

 1/459https://mbexc.uni-goettingen.de/archive/1/459 Research Data Archive MBExC (supplemental material)

 03av75f26https://ror.org/03av75f26 ROR identifier (03av75f26, Max Planck Institute for Multidisciplinary Sciences)

 05xy1nn52https://ror.org/05xy1nn52 ROR identifier (05xy1nn52, Multiscale Bioimaging)

 021ft0n22https://ror.org/021ft0n22 ROR identifier (021ft0n22, University Medical Center Göttingen)

 0524sp257https://ror.org/0524sp257 ROR identifier (0524sp257, University of Bristol)

 052gg0110https://ror.org/052gg0110 ROR identifier (052gg0110, University of Oxford)

 CVCL_0045https://scicrunch.org/resolver/CVCL_0045 SciCrunch identifier (RRID:CVCL_0045, HEK293)

 CVCL_Z232https://scicrunch.org/resolver/CVCL_Z232 SciCrunch identifier (RRID:CVCL_Z232, Schneider 2)

 SCR_006646https://scicrunch.org/resolver/SCR_006646 SciCrunch identifier (RRID:SCR_006646, BEDTools)

 SCR_005476https://scicrunch.org/resolver/SCR_005476 SciCrunch identifier (RRID:SCR_005476, Bowtie)

 SCR_011841https://scicrunch.org/resolver/SCR_011841 SciCrunch identifier (RRID:SCR_011841, cutadapt)

 SCR_015687https://scicrunch.org/resolver/SCR_015687 SciCrunch identifier (RRID:SCR_015687, DESeq2)

 SCR_005514https://scicrunch.org/resolver/SCR_005514 SciCrunch identifier (RRID:SCR_005514, HTSeq)

 SCR_014485https://scicrunch.org/resolver/SCR_014485 SciCrunch identifier (RRID:SCR_014485, MaxQuant)

 SCR_015753https://scicrunch.org/resolver/SCR_015753 SciCrunch identifier (RRID:SCR_015753, Perseus)

 SCR_017036https://scicrunch.org/resolver/SCR_017036 SciCrunch identifier (RRID:SCR_017036, Salmon)

 SCR_002105https://scicrunch.org/resolver/SCR_002105 SciCrunch identifier (RRID:SCR_002105, Samtools)

 SCR_004463https://scicrunch.org/resolver/SCR_004463 SciCrunch identifier (RRID:SCR_004463, STAR)

 cell.com...c1.pdfhttps://www.cell.com/cms/10.1016/j.molcel.2024.05.007/attachment/8d836ebd-956f-4689-a1fa-7cb8af8b8d2f/mmc1.pdf Supplemental material

 github.com/sklasfeld/DANPOS3https://github.com/sklasfeld/DANPOS3 Supplemental material (code, reused)

 goeseek.gwdguser.de/studies/176https://goeseek.gwdguser.de/studies/176 Supplemental material (goeseek study)

 cell.com...2.xlsxhttps://www.cell.com/cms/10.1016/j.molcel.2024.05.007/attachment/8606e0b0-1aec-4d6d-b177-54a2a638e184/mmc2.xlsx Supplemental material (table)

 cell.com...3.xlsxhttps://www.cell.com/cms/10.1016/j.molcel.2024.05.007/attachment/c0ba06c3-0a44-4800-aa95-6446fa2fcb12/mmc3.xlsx Supplemental material (table)

 cell.com...4.xlsxhttps://www.cell.com/cms/10.1016/j.molcel.2024.05.007/attachment/a915330c-edcb-44f8-b4ed-27ad5282c94c/mmc4.xlsx Supplemental material (table)

 cell.com...5.xlsxhttps://www.cell.com/cms/10.1016/j.molcel.2024.05.007/attachment/3e838f7c-cffc-4348-b204-ba2e08b6bfc9/mmc5.xlsx Supplemental material (table)

 mbexc.de...lease/https://mbexc.de/cdk7-kinase-activity-promotes-rna-polymerase-ii-promoter-escape-by-facilitating-initiation-factor-release/ Website entry (mbexc.de)

Linked Antibodies

PID	AG	Type	Antigen symbol	Antibody Registry ID	Name
primary-1229		primary		AB_2728744	Pol II Antibody
primary-1461		primary	POLR2A	AB_10615822	Anti-RNA polymerase II subunit B1 (phospho-CTD Ser-5) Antibody, clone 3E8
primary-1462		primary	MED26	AB_2798656	MED26 (D4B1X) Rabbit mAb
primary-1463		primary	GTF2B	AB_10709889	TFIIB Antikörper (D-3)
primary-1464		primary	GTF2E1	AB_778322	Anti-TFIIE alpha/GTF2E1 antibody
primary-1465		primary	NELFE	AB_1524076	Rabbit anti-NELFE Antibody Affinity Purified
primary-1466		primary	SUPT5H	AB_2878268	SUPT5H Polyklonaler Antikörper
primary-1467		primary	H2Av	AB_2737370	Spike-in Antibody