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Publication

Property	Value
Working Groups	RG Stadelmann-Nessler
Subproject	RA2.2
Open Access	Yes
Publication Type	Journal Article
Peer Reviewed	Yes
PMID	33082293
DOI	10.1126/science.abd2985
Publication Year	2020
Title	Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity
Journal	Science
ISSN	0036-8075
eISSN	1095-9203
URL	http://dx.doi.org/10.1126/science.abd2985
Pages	eabd2985
Journal Abbreviation	Science
Extra	TRR 274
Authors	Cantuti-Castelvetri L, Ojha R, Pedro LD, Djannatian M, Franz J, Kuivanen S, van der Meer F, Kallio K, Kaya T, Anastasina M, Smura T, Levanov L, Szirovicza L, Tobi A, Kallio-Kokko H, Österlund P, Joensuu M, Meunier FA, Butcher SJ, Winkler MS, Mollenhauer B, Helenius A, Gokce O, Teesalu T, Hepojoki J, Vapalahti O, Stadelmann C, Balistreri G, Simons M
First Author	Cantuti-Castelvetri L
Last Author	Simons M
Scholia	Wikidata-based representation at Scholia

External Resources

1786https://www.addgene.org/1786 Addgene identifier (reused)

science....bd2985https://www.science.org/doi/epdf/10.1126/science.abd2985 Article fulltext

github.c...NA-seqhttps://github.com/vandijklab/HBEC_SARS-CoV-2_scRNA-seq Dataset (Differentially expressed genes table, reused)

figshare...235471https://figshare.com/articles/HCL_DGE_Data/7235471 Dataset (Human lung data, reused)

gro-2/83594http://resolver.sub.uni-goettingen.de/purl?gro-2/83594 GRO.publications identifier

GSE139522https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE139522 NCBI GEO Dataset (GSE139522, reused)

GSE145926https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE145926 NCBI GEO Dataset (GSE145926, reused)

NC_045512.2https://www.ncbi.nlm.nih.gov/nuccore/NC_045512.2 NCBI nucleotide (NC_045512.2)

10090https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10090 NCBI taxonomy (mouse, Mus musculus)

9606https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 NCBI taxonomy (human, Homo sapiens)

0000-0002-0642-1610https://orcid.org/0000-0002-0642-1610 ORCID identifier (Ludovico Cantuti-Castelvetri)

0000-0001-7876-4607https://orcid.org/0000-0001-7876-4607 ORCID identifier (Ravi Kant Ojha)

0000-0003-3556-647Xhttps://orcid.org/0000-0003-3556-647X ORCID identifier (Liliana D. Pedro)

0000-0002-7759-6557https://orcid.org/0000-0002-7759-6557 ORCID identifier (Minou Djannatian)

0000-0001-7523-6622https://orcid.org/0000-0001-7523-6622 ORCID identifier (Jonas Franz)

0000-0002-2347-5397https://orcid.org/0000-0002-2347-5397 ORCID identifier (Suvi Kuivanen)

0000-0002-9433-9173https://orcid.org/0000-0002-9433-9173 ORCID identifier (Franziska van der Meer)

0000-0001-5926-8608https://orcid.org/0000-0001-5926-8608 ORCID identifier (Tugberk Kaya)

0000-0002-4555-6446https://orcid.org/0000-0002-4555-6446 ORCID identifier (Maria Anastasina)

0000-0003-1528-044Xhttps://orcid.org/0000-0003-1528-044X ORCID identifier (Leonora Szirovicza)

0000-0003-4797-5481https://orcid.org/0000-0003-4797-5481 ORCID identifier (Allan Tobi)

0000-0002-2229-6661https://orcid.org/0000-0002-2229-6661 ORCID identifier (Pamela Österlund)

0000-0002-4533-0455https://orcid.org/0000-0002-4533-0455 ORCID identifier (Merja Joensuu)

0000-0001-6400-1107https://orcid.org/0000-0001-6400-1107 ORCID identifier (Frederic A. Meunier)

0000-0001-7060-5871https://orcid.org/0000-0001-7060-5871 ORCID identifier (Sarah Jane Butcher)

0000-0001-6319-404Xhttps://orcid.org/0000-0001-6319-404X ORCID identifier (Ozgun Gokce)

0000-0002-9458-6385https://orcid.org/0000-0002-9458-6385 ORCID identifier (Tambet Teesalu)

0000-0001-5699-214Xhttps://orcid.org/0000-0001-5699-214X ORCID identifier (Jussi Hepojoki)

0000-0003-2270-6824https://orcid.org/0000-0003-2270-6824 ORCID identifier (Olli Pekka Vapalahti)

0000-0003-1766-5458https://orcid.org/0000-0003-1766-5458 ORCID identifier (Christine Stadelmann-Nessler)

0000-0002-3585-559Xhttps://orcid.org/0000-0002-3585-559X ORCID identifier (Giuseppe Balistreri)

0000-0001-5329-192Xhttps://orcid.org/0000-0001-5329-192X ORCID identifier (Mikael Jakob Simons)

8https://rdp.sfb274.de/literature/publications/8 Published Data Registry entry (TRR274)

1/160https://mbexc.uni-goettingen.de/archive/1/160 Research Data Archive (supplemental material)

05xy1nn52https://ror.org/05xy1nn52 ROR identifier (05xy1nn52, Multiscale Bioimaging)

021ft0n22https://ror.org/021ft0n22 ROR identifier (021ft0n22, University Medical Center Göttingen)

040af2s02https://ror.org/040af2s02 ROR identifier (040af2s02, University of Helsinki)

02kkvpp62https://ror.org/02kkvpp62 ROR identifier (02kkvpp62, Technical University of Munich)

03z77qz90https://ror.org/03z77qz90 ROR identifier (03z77qz90, University of Tartu)

00rqy9422https://ror.org/00rqy9422 ROR identifier (00rqy9422, University of Queensland)

05a28rw58https://ror.org/05a28rw58 ROR identifier (05a28rw58, ETH Zurich)

CVCL_0025https://scicrunch.org/resolver/CVCL_0025 SciCrunch identifier (RRID:CVCL_0025, Caco-2)

CVCL_0045https://scicrunch.org/resolver/CVCL_0045 SciCrunch identifier (RRID:CVCL_0045, HEK293)

CVCL_0063https://scicrunch.org/resolver/CVCL_0063 SciCrunch identifier (RRID:CVCL_0063, HEK293T)

CVCL_0059https://scicrunch.org/resolver/CVCL_0059 SciCrunch identifier (RRID:CVCL_0059, Vero)

SCR_007358https://scicrunch.org/resolver/SCR_007358 SciCrunch identifier (RRID:SCR_007358, CellProfiler)

SCR_002285https://scicrunch.org/resolver/SCR_002285 SciCrunch identifier (RRID:SCR_002285, Fiji)

SCR_002798https://scicrunch.org/resolver/SCR_002798 SciCrunch identifier (RRID:SCR_002798, GraphPad Prism)

SCR_005611https://scicrunch.org/resolver/SCR_005611 SciCrunch identifier (RRID:SCR_005611, SAMtools)

SCR_007322https://scicrunch.org/resolver/SCR_007322 SciCrunch identifier (RRID:SCR_007322, Seurat)

SCR_011848https://scicrunch.org/resolver/SCR_011848 SciCrunch identifier (RRID:SCR_011848, Trimmomatic)

science....sm.pdfhttps://www.science.org/doi/suppl/10.1126/science.abd2985/suppl_file/abd2985_cantuti-castelvetri_sm.pdf Supplemental material

science....st.pdfhttps://www.science.org/doi/suppl/10.1126/science.abd2985/suppl_file/abd2985_mdar_reproducibility_checklist.pdf Supplemental material (reporting summary)

mbexc.de...tem-2/https://mbexc.de/neuropilin-1-facilitates-sars-cov-2-cell-entry-and-provides-a-possible-pathway-into-the-central-nervous-system-2/ Website entry (mbexc.de)

Q100750024https://www.wikidata.org/wiki/Q100750024 Wikidata ID

Linked Antibodies

PID	Type	Antigen symbol	Antibody Registry ID	Name
primary-0011	primary	NRP1	AB_1640739	Anti-Neuropilin 1 antibody
primary-0012	primary	TUBB3	AB_430874	Anti-βIII Tubulin mAb
primary-0013	primary	NeuN	AB_11205760	Anti-NeuN Antibody
primary-0014	primary	GFP	AB_221570	GFP Antibody
primary-0015	primary	COL4	AB_2721907	Anti-Type IV Collagen-UNLB
primary-0016	primary	PECAM1	AB_2801330	PECAM-1 antibody
primary-0017	primary	AQP4	AB_2039734	Anti-Aquaporin 4 Antibody
primary-0025	primary	SARS	AB_2891144	Anti-SARS spike glycoprotein antibody [3A2] - Coronavirus
primary-0026	primary	NRP1	AB_2282634	Anti-neuropilin-1 Antibody
primary-0027	primary	ACE-2	AB_355722	ACE-2 Antibody
primary-0028	primary	Olig2	AB_494617	Anti-Human Olig2 Rabbit IgG
primary-0029	primary	SARS-CoV-2		SARS-CoV-2 (2019-nCoV) Spike RBD Antibody
primary-0030	primary	α Tubulin	AB_301787	Anti-alpha Tubulin antibody - Microtubule Marker
primary-0034	primary	TMPRSS2	AB_2892118	Anti-TMPRSS2 Antibody (H-4)
primary-0035	primary	α-Tubulin	AB_1904178	α-Tubulin (DM1A) Mouse mAb
secondary-0010	secondary		AB_2307338	AffiniPure Fab Fragment Donkey Anti-Mouse IgG (H+L)
secondary-0018	secondary		AB_2556542	Donkey anti-Mouse IgG (H+L) Secondary Antibody,Alexa Fluor 488
secondary-0019	secondary		AB_2535849	Goat anti-Rabbit IgG (H+L) Cross-Adsorbed Secondary Antibody, Alexa Fluor 555
secondary-0020	secondary		AB_2534096	Goat anti-Chicken IgY (H+L) Secondary Antibody, Alexa Fluor 488
secondary-0021	secondary		AB_2534102	Donkey anti-Goat IgG (H+L) Cross-Adsorbed Secondary Antibody, Alexa Fluor 488
secondary-0022	secondary		AB_2535853	Donkey anti-Goat IgG (H+L) Cross-Adsorbed Secondary Antibody, Alexa Fluor 555
secondary-0023	secondary		AB_2535844	Goat anti-Mouse IgG (H+L) Cross-Adsorbed Secondary Antibody, Alexa Fluor 555
secondary-0024	secondary		AB_2536183	Donkey anti-Rabbit IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor 647
secondary-0031	secondary		AB_10956166	IRDye® 680RD Goat anti-Rabbit IgG Secondary Antibody
secondary-0032	secondary		AB_143165	Goat anti-Rabbit IgG (H+L) Cross-Adsorbed Secondary Antibody, Alexa Fluor 488
secondary-0033	secondary		AB_2536100	Goat anti-Rabbit IgG (H+L), Superclonal™ Recombinant Secondary Antibody, Alexa Fluor 555

Technical Support: menoci@medizin.uni-goettingen.de

Department of Medical Informatics
University Medical Center Göttingen
Imprint

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External Resources

Linked Antibodies

Technical support

Links

Spokesperson

Prof. Dr. Tobias Moser

Spokesperson of Cluster of Excellence