| Property |
Value |
| Working Groups |
RG Stadelmann-Nessler |
| Subproject |
RA2.2 |
| Open Access |
Yes |
| Publication Type |
Journal Article |
| Peer Reviewed |
Yes |
| PMID |
33082293 |
| DOI |
10.1126/science.abd2985 |
| Publication Year |
2020 |
| Title |
Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity |
| Journal |
Science |
| ISSN |
0036-8075 |
| eISSN |
1095-9203 |
| URL |
http://dx.doi.org/10.1126/science.abd2985 |
| Pages |
eabd2985 |
| Journal Abbreviation |
Science |
| Extra |
TRR 274 |
| Authors |
Cantuti-Castelvetri L, Ojha R, Pedro LD, Djannatian M, Franz J, Kuivanen S, van der Meer F, Kallio K, Kaya T, Anastasina M, Smura T, Levanov L, Szirovicza L, Tobi A, Kallio-Kokko H, Österlund P, Joensuu M, Meunier FA, Butcher SJ, Winkler MS, Mollenhauer B, Helenius A, Gokce O, Teesalu T, Hepojoki J, Vapalahti O, Stadelmann C, Balistreri G, Simons M |
| First Author |
Cantuti-Castelvetri L |
| Last Author |
Simons M |
External Resources
1786https://www.addgene.org/1786 Addgene identifier (reused)
science....bd2985https://www.science.org/doi/epdf/10.1126/science.abd2985 Article fulltext
github.c...NA-seqhttps://github.com/vandijklab/HBEC_SARS-CoV-2_scRNA-seq Dataset (Differentially expressed genes table, reused)
figshare...235471https://figshare.com/articles/HCL_DGE_Data/7235471 Dataset (Human lung data, reused)
2/83594http://resolver.sub.uni-goettingen.de/purl?2/83594 GRO.publications identifier
GSE139522https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE139522 NCBI GEO Dataset (GSE139522, reused)
GSE145926https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE145926 NCBI GEO Dataset (GSE145926, reused)
NC_045512.2https://www.ncbi.nlm.nih.gov/nuccore/NC_045512.2 NCBI nucleotide (NC_045512.2)
10090https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10090 NCBI taxonomy (mouse, Mus musculus)
9606https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 NCBI taxonomy (human, Homo sapiens)
0000-0002-0642-1610https://orcid.org/0000-0002-0642-1610 ORCID identifier (Ludovico Cantuti-Castelvetri)
0000-0001-7876-4607https://orcid.org/0000-0001-7876-4607 ORCID identifier (Ravi Kant Ojha)
0000-0003-3556-647Xhttps://orcid.org/0000-0003-3556-647X ORCID identifier (Liliana D. Pedro)
0000-0002-7759-6557https://orcid.org/0000-0002-7759-6557 ORCID identifier (Minou Djannatian)
0000-0001-7523-6622https://orcid.org/0000-0001-7523-6622 ORCID identifier (Jonas Franz)
0000-0002-2347-5397https://orcid.org/0000-0002-2347-5397 ORCID identifier (Suvi Kuivanen)
0000-0002-9433-9173https://orcid.org/0000-0002-9433-9173 ORCID identifier (Franziska van der Meer)
0000-0001-5926-8608https://orcid.org/0000-0001-5926-8608 ORCID identifier (Tugberk Kaya)
0000-0002-4555-6446https://orcid.org/0000-0002-4555-6446 ORCID identifier (Maria Anastasina)
0000-0003-1528-044Xhttps://orcid.org/0000-0003-1528-044X ORCID identifier (Leonora Szirovicza)
0000-0003-4797-5481https://orcid.org/0000-0003-4797-5481 ORCID identifier (Allan Tobi)
0000-0002-2229-6661https://orcid.org/0000-0002-2229-6661 ORCID identifier (Pamela Österlund)
0000-0002-4533-0455https://orcid.org/0000-0002-4533-0455 ORCID identifier (Merja Joensuu)
0000-0001-6400-1107https://orcid.org/0000-0001-6400-1107 ORCID identifier (Frederic A. Meunier)
0000-0001-7060-5871https://orcid.org/0000-0001-7060-5871 ORCID identifier (Sarah Jane Butcher)
0000-0001-6319-404Xhttps://orcid.org/0000-0001-6319-404X ORCID identifier (Ozgun Gokce)
0000-0002-9458-6385https://orcid.org/0000-0002-9458-6385 ORCID identifier (Tambet Teesalu)
0000-0001-5699-214Xhttps://orcid.org/0000-0001-5699-214X ORCID identifier (Jussi Hepojoki)
0000-0003-2270-6824https://orcid.org/0000-0003-2270-6824 ORCID identifier (Olli Pekka Vapalahti)
0000-0003-1766-5458https://orcid.org/0000-0003-1766-5458 ORCID identifier (Christine Stadelmann-Nessler)
0000-0002-3585-559Xhttps://orcid.org/0000-0002-3585-559X ORCID identifier (Giuseppe Balistreri)
0000-0001-5329-192Xhttps://orcid.org/0000-0001-5329-192X ORCID identifier (Mikael Jakob Simons)
8https://rdp.sfb274.de/literature/publications/8 Published Data Registry entry (TRR274)
1/160https://mbexc.uni-goettingen.de/archive/1/160 Research Data Archive (supplemental material)
05xy1nn52https://ror.org/05xy1nn52 ROR identifier (05xy1nn52, Multiscale Bioimaging)
021ft0n22https://ror.org/021ft0n22 ROR identifier (021ft0n22, University Medical Center Göttingen)
040af2s02https://ror.org/040af2s02 ROR identifier (040af2s02, University of Helsinki)
02kkvpp62https://ror.org/02kkvpp62 ROR identifier (02kkvpp62, Technical University of Munich)
03z77qz90https://ror.org/03z77qz90 ROR identifier (03z77qz90, University of Tartu)
00rqy9422https://ror.org/00rqy9422 ROR identifier (00rqy9422, University of Queensland)
05a28rw58https://ror.org/05a28rw58 ROR identifier (05a28rw58, ETH Zurich)
CVCL_0025https://scicrunch.org/resolver/CVCL_0025 SciCrunch identifier (RRID:CVCL_0025, Caco-2)
CVCL_0045https://scicrunch.org/resolver/CVCL_0045 SciCrunch identifier (RRID:CVCL_0045, HEK293)
CVCL_0063https://scicrunch.org/resolver/CVCL_0063 SciCrunch identifier (RRID:CVCL_0063, HEK293T)
CVCL_0059https://scicrunch.org/resolver/CVCL_0059 SciCrunch identifier (RRID:CVCL_0059, Vero)
SCR_007358https://scicrunch.org/resolver/SCR_007358 SciCrunch identifier (RRID:SCR_007358, CellProfiler)
SCR_002285https://scicrunch.org/resolver/SCR_002285 SciCrunch identifier (RRID:SCR_002285, Fiji)
SCR_002798https://scicrunch.org/resolver/SCR_002798 SciCrunch identifier (RRID:SCR_002798, GraphPad Prism)
SCR_005611https://scicrunch.org/resolver/SCR_005611 SciCrunch identifier (RRID:SCR_005611, SAMtools)
SCR_007322https://scicrunch.org/resolver/SCR_007322 SciCrunch identifier (RRID:SCR_007322, Seurat)
SCR_011848https://scicrunch.org/resolver/SCR_011848 SciCrunch identifier (RRID:SCR_011848, Trimmomatic)
science....sm.pdfhttps://www.science.org/doi/suppl/10.1126/science.abd2985/suppl_file/abd2985_cantuti-castelvetri_sm.pdf Supplemental material
science....st.pdfhttps://www.science.org/doi/suppl/10.1126/science.abd2985/suppl_file/abd2985_mdar_reproducibility_checklist.pdf Supplemental material (reporting summary)
mbexc.de...tem-2/https://mbexc.de/neuropilin-1-facilitates-sars-cov-2-cell-entry-and-provides-a-possible-pathway-into-the-central-nervous-system-2/ Website entry (mbexc.de)
Q100750024https://www.wikidata.org/wiki/Q100750024 Wikidata ID
Linked Antibodies
| PID |
AG |
Type |
Antigen symbol |
Antibody Registry ID |
Name |
| primary-0011 |
|
primary |
NRP1 |
AB_1640739 |
Anti-Neuropilin 1 antibody |
| primary-0012 |
|
primary |
TUBB3 |
AB_430874 |
Anti-βIII Tubulin mAb |
| primary-0013 |
|
primary |
NeuN |
AB_11205760 |
Anti-NeuN Antibody |
| primary-0014 |
|
primary |
GFP |
AB_221570 |
GFP Antibody |
| primary-0015 |
|
primary |
COL4 |
AB_2721907 |
Anti-Type IV Collagen-UNLB |
| primary-0016 |
|
primary |
PECAM1 |
AB_2801330 |
PECAM-1 antibody |
| primary-0017 |
|
primary |
AQP4 |
AB_2039734 |
Anti-Aquaporin 4 Antibody |
| primary-0025 |
|
primary |
SARS |
AB_2891144 |
Anti-SARS spike glycoprotein antibody [3A2] - Coronavirus |
| primary-0026 |
|
primary |
NRP1 |
AB_2282634 |
Anti-neuropilin-1 Antibody |
| primary-0027 |
|
primary |
ACE-2 |
AB_355722 |
ACE-2 Antibody |
| primary-0028 |
|
primary |
Olig2 |
AB_494617 |
Anti-Human Olig2 Rabbit IgG |
| primary-0029 |
|
primary |
SARS-CoV-2 |
|
SARS-CoV-2 (2019-nCoV) Spike RBD Antibody |
| primary-0030 |
|
primary |
α Tubulin |
AB_301787 |
Anti-alpha Tubulin antibody - Microtubule Marker |
| primary-0034 |
|
primary |
TMPRSS2 |
AB_2892118 |
Anti-TMPRSS2 Antibody (H-4) |
| primary-0035 |
|
primary |
α-Tubulin |
AB_1904178 |
α-Tubulin (DM1A) Mouse mAb |
| secondary-0010 |
|
secondary |
|
AB_2307338 |
AffiniPure Fab Fragment Donkey Anti-Mouse IgG (H+L) |
| secondary-0018 |
|
secondary |
|
AB_2556542 |
Donkey anti-Mouse IgG (H+L) Secondary Antibody,Alexa Fluor 488 |
| secondary-0019 |
|
secondary |
|
AB_2535849 |
Goat anti-Rabbit IgG (H+L) Cross-Adsorbed Secondary Antibody, Alexa Fluor 555 |
| secondary-0020 |
|
secondary |
|
AB_2534096 |
Goat anti-Chicken IgY (H+L) Secondary Antibody, Alexa Fluor 488 |
| secondary-0021 |
|
secondary |
|
AB_2534102 |
Donkey anti-Goat IgG (H+L) Cross-Adsorbed Secondary Antibody, Alexa Fluor 488 |
| secondary-0022 |
|
secondary |
|
AB_2535853 |
Donkey anti-Goat IgG (H+L) Cross-Adsorbed Secondary Antibody, Alexa Fluor 555 |
| secondary-0023 |
|
secondary |
|
AB_2535844 |
Goat anti-Mouse IgG (H+L) Cross-Adsorbed Secondary Antibody, Alexa Fluor 555 |
| secondary-0024 |
|
secondary |
|
AB_2536183 |
Donkey anti-Rabbit IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor 647 |
| secondary-0031 |
|
secondary |
|
AB_10956166 |
IRDye® 680RD Goat anti-Rabbit IgG Secondary Antibody |
| secondary-0032 |
|
secondary |
|
AB_143165 |
Goat anti-Rabbit IgG (H+L) Cross-Adsorbed Secondary Antibody, Alexa Fluor 488 |
| secondary-0033 |
|
secondary |
|
AB_2536100 |
Goat anti-Rabbit IgG (H+L), Superclonal™ Recombinant Secondary Antibody, Alexa Fluor 555 |