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Publication

Property	Value
Working Groups	RG Cyganek, RG Wollnik, RG Zimmermann
Subproject	None
Open Access	Yes
Publication Type	Journal Article
Peer Reviewed	Yes
PMID	41988707
DOI	10.1161/circulationaha.125.074155
Publication Year	2026
Title	Targeting Interleukin-8–Mediated Cellular Crosstalk Reverses Hypertrophic Cardiomyopathy and Cardiac Fibrosis in Noonan Syndrome
Journal	Circulation
ISSN	0009-7322
eISSN	1524-4539
URL	https://doi.org/10.1161/circulationaha.125.074155
Journal Abbreviation	Circulation
Authors	Fell J, Pavez-Giani M, Koitka F, Kensah G, Santos GL, van der Vorst EP, Lenz C, Salinas G, Busley AV, Fedorenko A, Hindmarsh R, Wolf CM, Lutz S, Hasenfuss G, Zimmermann W, Wollnik B, Cyganek L
First Author	Fell J
Last Author	Cyganek L

External Resources

90227https://www.addgene.org/90227 Addgene identifier (90227, reused)

12259https://www.addgene.org/12259 Addgene identifier (12259, reused)

12260https://www.addgene.org/12260 Addgene identifier (12260, reused)

file:///...ac.pdfhttp://file:///C:/Users/kulikova/Downloads/fell-et-al-2026-targeting-interleukin-8-mediated-cellular-crosstalk-reverses-hypertrophic-cardiomyopathy-and-cardiac.pdf Article fulltext

gro-2/165140http://resolver.sub.uni-goettingen.de/purl?gro-2/165140 GRO.publications identifier

GSE271775https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE271775 NCBI GEO Dataset (GSE271775)

0000-0002-3330-9384https://orcid.org/0000-0002-3330-9384 ORCID identifier (Mario Pavez-Giani)

0009-0007-5226-9676https://orcid.org/0009-0007-5226-9676 ORCID identifier (Fabian Koitka)

0000-0003-0219-8279https://orcid.org/0000-0003-0219-8279 ORCID identifier (George Kensah)

0000-0001-7253-9855https://orcid.org/0000-0001-7253-9855 ORCID identifier (Gabriela Leão Santos)

0000-0001-5771-6278https://orcid.org/0000-0001-5771-6278 ORCID identifier (Emiel van der Vorst)

0000-0002-0946-8166https://orcid.org/0000-0002-0946-8166 ORCID identifier (Christof Lenz)

0000-0001-8269-2669https://orcid.org/0000-0001-8269-2669 ORCID identifier (Gabriela Salinas-Riester)

0000-0002-5036-0093https://orcid.org/0000-0002-5036-0093 ORCID identifier (Alexandra Viktoria Busley)

0009-0008-1090-2477https://orcid.org/0009-0008-1090-2477 ORCID identifier (Alisa Fedorenko)

0000-0003-4701-5843https://orcid.org/0000-0003-4701-5843 ORCID identifier (Cordula Wolf)

0000-0002-0554-8070https://orcid.org/0000-0002-0554-8070 ORCID identifier (Susanne Lutz)

0000-0002-5942-361Xhttps://orcid.org/0000-0002-5942-361X ORCID identifier (Gerd Hasenfuß)

0000-0003-1190-4040https://orcid.org/0000-0003-1190-4040 ORCID identifier (Wolfram-Hubertus Zimmermann)

0000-0003-2589-0364https://orcid.org/0000-0003-2589-0364 ORCID identifier (Bernd Wollnik)

0000-0001-9120-1382https://orcid.org/0000-0001-9120-1382 ORCID identifier (Lukas Cyganek)

PXD053691http://proteomecentral.proteomexchange.org/cgi/GetDataset?ID=PXD053691 Pride proteome dataset (PXD053691)

580https://sfb1002.med.uni-goettingen.de/production/literature/publications/580 Published Data Registry entry (CRC 1002)

1/794https://mbexc.uni-goettingen.de/archive/1/794 Research Data Archive (supplemental material)

04hbwba26https://ror.org/04hbwba26 ROR identifier (04hbwba26, Deutsches Herzzentrum München)

01s1h3j07https://ror.org/01s1h3j07 ROR identifier (01s1h3j07, Fraunhofer Institute for Translational Medicine and Pharmacology)

05591te55https://ror.org/05591te55 ROR identifier (05591te55, Ludwig Maximilian University of Munich)

05xy1nn52https://ror.org/05xy1nn52 ROR identifier (05xy1nn52, Multiscale Bioimaging)

02gm5zw39https://ror.org/02gm5zw39 ROR identifier (02gm5zw39, Universitätsklinikum Aachen)

021ft0n22https://ror.org/021ft0n22 ROR identifier (021ft0n22, University Medical Center Göttingen)

01y9bpm73https://ror.org/01y9bpm73 ROR identifier (01y9bpm73, University of Göttingen)

SCR_015058https://scicrunch.org/resolver/SCR_015058 SciCrunch identifier (RRID:SCR_015058, bcl2fastq)

SCR_019214https://scicrunch.org/resolver/SCR_019214 SciCrunch identifier (RRID:SCR_019214, biomaRt)

SCR_019037https://scicrunch.org/resolver/SCR_019037 SciCrunch identifier (RRID:SCR_019037, Bio-Rad: ChemiDoc MP Imaging System)

SCR_002080https://scicrunch.org/resolver/SCR_002080 SciCrunch identifier (RRID:SCR_002080, CASY Cell Counter and Analyser System Model TT)

SCR_021828https://scicrunch.org/resolver/SCR_021828 SciCrunch identifier (RRID:SCR_021828, Circa)

SCR_005748https://scicrunch.org/resolver/SCR_005748 SciCrunch identifier (RRID:SCR_005748, ClueGo)

SCR_003032https://scicrunch.org/resolver/SCR_003032 SciCrunch identifier (RRID:SCR_003032, Cytoscape)

SCR_015687https://scicrunch.org/resolver/SCR_015687 SciCrunch identifier (RRID:SCR_015687, DESeq2)

SCR_019840https://scicrunch.org/resolver/SCR_019840 SciCrunch identifier (RRID:SCR_019840, Dionex: Ultimate 3000 system)

SCR_014583https://scicrunch.org/resolver/SCR_014583 SciCrunch identifier (RRID:SCR_014583, FastQC)

SCR_010973https://scicrunch.org/resolver/SCR_010973 SciCrunch identifier (RRID:SCR_010973, GenomeStudio)

SCR_002798https://scicrunch.org/resolver/SCR_002798 SciCrunch identifier (RRID:SCR_002798, GraphPad Prism)

SCR_003070https://scicrunch.org/resolver/SCR_003070 SciCrunch identifier (RRID:SCR_003070, ImageJ)

SCR_020124https://scicrunch.org/resolver/SCR_020124 SciCrunch identifier (RRID:SCR_020124, Illumina: BeadArray Reader)

SCR_016386https://scicrunch.org/resolver/SCR_016386 SciCrunch identifier (RRID:SCR_016386, Illumina HiSeq 3000/HiSeq 4000 Sequencing System)

SCR_003420https://scicrunch.org/resolver/SCR_003420 SciCrunch identifier (RRID:SCR_003420, nSolver Analysis Software)

SCR_015753https://scicrunch.org/resolver/SCR_015753 SciCrunch identifier (RRID:SCR_015753, Perseus)

SCR_027715https://www.addgene.org/SCR_027715 SciCrunch identifier (RRID:SCR_027715, StarDist)

SCR_027000https://scicrunch.org/resolver/SCR_027000 SciCrunch identifier (RRID:SCR_027000, Thermo Fisher: Orbitrap Exploris 480 Mass Spectrometer)

SCR_023147https://scicrunch.org/resolver/SCR_023147 SciCrunch identifier (RRID:SCR_023147, Thermo Fisher: Sartorius: IncuCyte S3 Live Cell Analysis System)

SCR_018623https://scicrunch.org/resolver/SCR_018623 SciCrunch identifier (RRID:SCR_018623, Qiagen: Tissue Lyser II)

SCR_024706https://scicrunch.org/resolver/SCR_024706 SciCrunch identifier (RRID:SCR_024706, Zeiss: Axio Imager M2)

SCR_027509https://scicrunch.org/resolver/SCR_027509 SciCrunch identifier (RRID:SCR_027509, Zeiss: SteREO Discovery.V12)

ahajourn...01.pdfhttps://www.ahajournals.org/doi/suppl/10.1161/CIRCULATIONAHA.125.074155/suppl_file/circ-2025-074155-s01.pdf Supplemental material

ahajourn...02.pdfhttps://www.ahajournals.org/doi/suppl/10.1161/CIRCULATIONAHA.125.074155/suppl_file/circ-2025-074155-s02.pdf Supplemental material

mbexc.de...drome/https://mbexc.de/targeting-interleukin-8-mediated-cellular-crosstalk-reverses-hypertrophic-cardiomyopathy-and-cardiac-fibrosis-in-noonan-syndrome/ Website entry (mbexc.de)

Linked Antibodies

PID	Type	Antigen symbol	Antibody Registry ID	Name
primary-0097	primary	MAPK	AB_2139682	Phospho-p38 MAPK (Thr180/Tyr182) (D3F9) XP Rabbit mAb antibody
primary-0098	primary	p38 MAPK	AB_330713	p38 MAPK Antibody
primary-0099	primary	MAPK3/MAPK1	AB_331646	Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) Antibody
primary-0100	primary	MAPK3/MAPK1	AB_330744	p44/42 MAPK (Erk1/2) Antibody
primary-0102	primary	ACTN2	AB_476766	Anti-α-Actinin (Sarcomeric) antibody
primary-0205	primary	RPS6	AB_331355	S6 Ribosomal Protein (5G10) Rabbit mAb
primary-0472	primary	TRA-1-60	AB_778563	Anti-TRA-1-60 (R) antibody [TRA-1-60]
primary-0473	primary	TRA-1-60	AB_1645379	Alexa Fluor® 488 Mouse anti-Human TRA-1-60 Antigen
primary-0815	primary	VCL	AB_477629	Monoclonal Anti-Vinculin antibody
primary-1155	primary	Oct3	AB_2784442	Oct3/4 Antibody, anti-human/mouse, REAfinity
primary-1157	primary		AB_2536677	Nanog Monoclonal Antibody (23D2-3C6)
primary-1160	primary	MRAS	AB_10950895	MRAS Polyclonal antibody
primary-1163	primary	RAS10	AB_2121151	Anti-Ras-Antikörper, Klon RAS10
primary-1183	primary	TNNI3	AB_11000742	Cardiac Troponin T Monoclonal Antibody (13-11)
primary-1641	primary	LZTR1	AB_3076250	Anti-LZTR1 antibody [EPR25253-51]
primary-1643	primary	RIT1	AB_882379	Anti-RIT1/RIT antibody
primary-2009	primary	EIF4EBP1	AB_2097841	4E-BP1 monoclonal rabbit
primary-2010	primary	4E-BP1	AB_560835	Phospho-4E-BP1 monoclonal rabbit
primary-2011	primary		AB_476766	α-actinin monoclonal mouse
primary-2012	primary		AB_329827	AKT polyclonal rabbit
primary-2013	primary		AB_329825	Phospho-AKT polyclonal rabbit
primary-2014	primary	CDH5	AB_2077957	VE-cadherin (F-8)
primary-2018	primary	MAPK7	AB_330491	ERK5 polyclonal rabbit
primary-2019	primary	COL1A1	AB_2920541	COL1A1 monoclonal mouse
primary-2020	primary		AB_2140424	Phospho-ERK5 polyclonal rabbit
primary-2021	primary	SAPK/JNK	AB_2250373	JNK polyclonal rabbit
primary-2022	primary	SAPK/JNK	AB_331659	Phospho-JNK polyclonal rabbit
primary-2023	primary	MKI67	AB_2687446	Ki-67 monoclonal rabbit
primary-2024	primary	MEK1/2	AB_823567	MEK1/2 polyclonal rabbit
primary-2025	primary	MEK1/2	AB_331648	Phospho-MEK1/2 polyclonal rabbit
primary-2026	primary	CD31	AB_779679	PECAM1 monoclonal mouse
primary-2027	primary	RPS6	AB_916156	Phospho-S6 monoclonal rabbit
primary-2028	primary	RPS6KB1	AB_390722	S6K monoclonal rabbit
primary-2029	primary	RPS6KB1	AB_2269803	Phospho-S6K monoclonal rabbit
secondary-0032	secondary		AB_143165	Goat anti-Rabbit IgG (H+L) Cross-Adsorbed Secondary Antibody, Alexa Fluor 488
secondary-0491	secondary		AB_2536180	Donkey anti-Mouse IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor 555
secondary-1161	secondary		AB_2722659	Kaninchen-IgG, HRP-verknüpfter Vollantikörper
secondary-1162	secondary		AB_772210	Maus-IgG, HRP-verknüpfter Vollantikörper