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Property	Value
Working Groups	RG Outeiro
Subproject	None
Open Access	Yes
Publication Type	Preprint
Peer Reviewed	No
DOI	10.1101/2025.06.06.657340
Publication Year	2025
Title	Dual effect of α-synuclein disease variants on condensate formation
Journal	bioRxiv
eISSN	2692-8205
URL	https://doi.org/10.1101/2025.06.06.657340
Journal Abbreviation	bioRxiv
Extra	Not yet finally published in a peer-reviewed journal
Authors	Chandran A, Agarwal A, Wang T, Amaral L, Chaves SR, Outeiro TF, Lautenschläger J
First Author	Chandran A
Last Author	Lautenschläger J

 External Resources

 12251https://www.addgene.org/12251 Addgene identifier (12251, reused)

 12253https://www.addgene.org/12253 Addgene identifier (12253, reused)

 12259https://www.addgene.org/12259 Addgene identifier (12259, reused)

 45147https://www.addgene.org/45147 Addgene identifier (45147, reused)

 48138https://www.addgene.org/48138 Addgene identifier (48138, reused)

 54635https://www.addgene.org/54635 Addgene identifier (54635, reused)

 85048https://www.addgene.org/85048 Addgene identifier (85048, reused)

 90992https://www.addgene.org/90992 Addgene identifier (90992, reused)

 96808https://www.addgene.org/96808 Addgene identifier (96808, reused)

 137811https://www.addgene.org/137811 Addgene identifier (137811, reused)

 178032https://www.addgene.org/178032 Addgene identifier (178032, reused)

 197034https://www.addgene.org/197034 Addgene identifier (197034, reused)

 biorxiv....ll.pdfhttps://www.biorxiv.org/content/10.1101/2025.06.06.657340v1.full.pdf Article fulltext

 2/149994https://publications.goettingen-research-online.de/handle/2/149994 GRO.publications identifier

 12374https://pubchem.ncbi.nlm.nih.gov/compound/12374 NCBI PubChem (12374, Hexane-1,6-diol)

 9606https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 NCBI taxonomy (human, Homo sapiens)

 1247190https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=1247190 NCBI taxonomy (yeast, Saccharomyces cerevisiae BY4741)

 0000-0003-0536-114Xhttps://orcid.org/0000-0003-0536-114X ORCID identifier (Aswathy Chandran)

 0009-0000-5229-4846https://orcid.org/0009-0000-5229-4846 ORCID identifier (Aishwarya Agarwal)

 0000-0003-2843-628Xhttps://orcid.org/0000-0003-2843-628X ORCID identifier (Leslie Amaral)

 0000-0002-6004-9872https://orcid.org/0000-0002-6004-9872 ORCID identifier (Susana R. Chaves)

 0000-0003-1679-1727https://orcid.org/0000-0003-1679-1727 ORCID identifier (Tiago Fleming Outeiro)

 0000-0001-7788-7074https://orcid.org/0000-0001-7788-7074 ORCID identifier (Janin Lautenschläger)

 391https://sfb1286.uni-goettingen.de/literature/publications/391 Published Data Registry entry (CRC 1286)

 1/623https://mbexc.uni-goettingen.de/archive/1/623 Research Data Archive (supplemental material)

 05xy1nn52https://ror.org/05xy1nn52 ROR identifier (05xy1nn52, Multiscale Bioimaging)

 01kj2bm70https://ror.org/01kj2bm70 ROR identifier (01kj2bm70, Newcastle University)

 021ft0n22https://ror.org/021ft0n22 ROR identifier (021ft0n22, University Medical Center Göttingen)

 013meh722https://ror.org/013meh722 ROR identifier (013meh722, University of Cambridge)

 037wpkx04https://ror.org/037wpkx04 ROR identifier (037wpkx04, University of Minho)

 CVCL_0030https://scicrunch.org/resolver/CVCL_0030 SciCrunch identifier (RRID:CVCL_0030, HeLa)

 SCR_002285https://scicrunch.org/resolver/SCR_002285 SciCrunch identifier (RRID:SCR_002285, Fiji)

 SCR_002798https://scicrunch.org/resolver/SCR_002798 SciCrunch identifier (RRID:SCR_002798, GraphPad Prism)

 SCR_016137https://scicrunch.org/resolver/SCR_016137 SciCrunch identifier (RRID:SCR_016137, Microsoft Excel)

 SCR_020922https://scicrunch.org/resolver/SCR_020922 SciCrunch identifier (RRID:SCR_020922, Zeiss LSM 780 Confocal Laser Scanning Microscope)

 SCR_020925https://scicrunch.org/resolver/SCR_020925 SciCrunch identifier (RRID:SCR_020925, Zeiss LSM 880 with Airyscan Confocal Laser Scanning Microscope)

 SCR_013672https://scicrunch.org/resolver/SCR_013672 SciCrunch identifier (RRID:SCR_013672, ZEN Digital Imaging for Light Microscopy)

 biorxiv....d=truehttps://www.biorxiv.org/content/biorxiv/early/2025/06/10/2025.06.06.657340/DC1/embed/media-1.docx?download=true Supplemental material (table)

 biorxiv....d=truehttps://www.biorxiv.org/content/biorxiv/early/2025/06/10/2025.06.06.657340/DC2/embed/media-2.docx?download=true Supplemental material (table)

 biorxiv....d=truehttps://www.biorxiv.org/content/biorxiv/early/2025/06/10/2025.06.06.657340/DC3/embed/media-3.avi?download=true Supplemental material (video)

 biorxiv....d=truehttps://www.biorxiv.org/content/biorxiv/early/2025/06/10/2025.06.06.657340/DC4/embed/media-4.avi?download=true Supplemental material (video)

 mbexc.de...ation/https://mbexc.de/dual-effect-of-alpha-synuclein-disease-variants-on-condensate-formation/ Website entry (mbexc.de)

Linked Antibodies

PID	AG	Type	Antigen symbol	Antibody Registry ID	Name
primary-1726		primary	SNCA/SNCB	AB_2619811	alpha Synuclein antibody
primary-1791		primary		AB_2734593, AB_2564891	Purified anti-α-Synuclein Phospho (Ser129) Antibody
primary-1928		primary		AB_10697029	StemLight™ Pluripotency Transcription Factor Antibody Kit
primary-1929		primary	TBB3	AB_10691594	β3-Tubulin (D65A4) XP® Rabbit mAb
primary-1930		primary		AB_2925241	Alpha-synuclein Monoclonal Antibody (LB509)
secondary-1792		secondary		AB_2534116	F(ab')2-Goat anti-Rabbit IgG (H+L) Cross-Adsorbed Secondary Antibody, Alexa Fluor™ 594
secondary-1931		secondary		AB_2534087	F(ab')2-Goat anti-Mouse IgG (H+L) Cross-Adsorbed Secondary Antibody, Alexa Fluor™ 594
secondary-1932		secondary		AB_2534114	F(ab')2-Goat anti-Rabbit IgG (H+L) Cross-Adsorbed Secondary Antibody, Alexa Fluor™ 488
secondary-1933		secondary		AB_2534084	F(ab')2-Goat anti-Mouse IgG (H+L) Cross-Adsorbed Secondary Antibody, Alexa Fluor™ 488
secondary-1934		secondary		AB_2556774	Goat anti-Mouse IgG (H+L) Secondary Antibody, DyLight™ 800 4X PEG
secondary-1935		secondary		AB_614946	Goat anti-Rabbit IgG (H+L) Secondary Antibody, DyLight™ 680