| Property |
Value |
| Working Groups |
RG Griesinger |
| Subproject |
None |
| Open Access |
Yes |
| Publication Type |
Preprint |
| Peer Reviewed |
No |
| DOI |
10.1101/2025.03.11.642540 |
| Publication Year |
2025 |
| Title |
Anle138b ameliorates pathological phenotypes in mouse and cellular models of Huntington’s disease |
| Journal |
bioRxiv |
| eISSN |
2692-8205 |
| URL |
https://doi.org/10.1101/2025.03.11.642540 |
| Journal Abbreviation |
bioRxiv |
| Extra |
Final article published in EMBO Molecular Medicine here: doi:10.1038/s44321-026-00459-9 |
| Authors |
da Silva Padilha M, Koyuncu S, Chabanis E, Ryazanov S, Leonov A, Vilchez D, Klein R, Giese A, Griesinger C, Dudanova I |
| First Author |
da Silva Padilha M |
| Last Author |
Dudanova I |
External Resources
biorxiv....ll.pdfhttps://www.biorxiv.org/content/10.1101/2025.03.11.642540v1.full.pdf Article fulltext
2/151216https://publications.goettingen-research-online.de/handle/2/151216 GRO.publications identifier
10090https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10090 NCBI taxonomy (mouse, Mus musculus)
0000-0001-8141-7163https://orcid.org/0000-0001-8141-7163 ORCID identifier (Miguel da Silva Padilha)
0000-0001-7937-3974https://orcid.org/0000-0001-7937-3974 ORCID identifier (Seda Koyuncu)
0009-0002-2924-7085https://orcid.org/0009-0002-2924-7085 ORCID identifier (Evangeline Chabanis)
0000-0002-2685-7956https://orcid.org/0000-0002-2685-7956 ORCID identifier (Sergey Ryazanov)
0000-0002-5586-9382https://orcid.org/0000-0002-5586-9382 ORCID identifier (Andrei Leonov)
0000-0002-0801-0743https://orcid.org/0000-0002-0801-0743 ORCID identifier (David Vilchez)
0000-0002-3109-0163https://orcid.org/0000-0002-3109-0163 ORCID identifier (Rüdiger Klein)
0000-0002-8238-4102https://orcid.org/0000-0002-8238-4102 ORCID identifier (Armin Giese)
0000-0002-1266-4344https://orcid.org/0000-0002-1266-4344 ORCID identifier (Christian Griesinger)
0000-0003-1052-8485https://orcid.org/0000-0003-1052-8485 ORCID identifier (Irina Dudanova)
1414https://prod.mbexc.uni-goettingen.de/literature/publications/1414 Published Data Registry entry (MBExC, final article)
04c4bwh63https://ror.org/04c4bwh63 ROR identifier (04c4bwh63, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases)
03g267s60https://ror.org/03g267s60 ROR identifier (03g267s60, Max Planck Institute for Biological Intelligence)
03av75f26https://ror.org/03av75f26 ROR identifier (03av75f26, Max Planck Institute for Multidisciplinary Sciences)
05xy1nn52https://ror.org/05xy1nn52 ROR identifier (05xy1nn52, Multiscale Bioimaging)
05mxhda18https://ror.org/05mxhda18 ROR identifier (05mxhda18, University Hospital Cologne)
IMSR_JAX:002810https://scicrunch.org/resolver/IMSR_JAX:002810 SciCrunch identifier (RRID:IMSR_JAX:002810, B6CBA-Tg(HDexon1)62Gpb/1J)
IMSR_JAX:029928https://scicrunch.org/resolver/IMSR_JAX:029928 SciCrunch identifier (RRID:IMSR_JAX:029928, B6.129S1-Htttm1.1Mfc/190ChdiJ)
SCR_002285https://scicrunch.org/resolver/SCR_002285 SciCrunch identifier (RRID:SCR_002285, Fiji)
SCR_002798https://scicrunch.org/resolver/SCR_002798 SciCrunch identifier (RRID:SCR_002798, GraphPad Prism)
SCR_003070https://scicrunch.org/resolver/SCR_003070 SciCrunch identifier (RRID:SCR_003070, ImageJ)
SCR_024663https://scicrunch.org/resolver/SCR_024663 SciCrunch identifier (RRID:SCR_024663, Leica STELLARIS 5 microscope)
SCR_023794https://scicrunch.org/resolver/SCR_023794 SciCrunch identifier (RRID:SCR_023794, Leica Thunder Imager Live Cell system)
mbexc.de...sease/https://mbexc.de/anle138b-ameliorates-pathological-phenotypes-in-mouse-and-cellular-models-of-huntingtons-disease/ Website entry (mbexc.de)
Linked Antibodies
| PID |
AG |
Type |
Antigen symbol |
Antibody Registry ID |
Name |
| primary-0107 |
 |
primary |
MAP2 |
AB_2138178, AB_350528 |
MAP2 Antibody |
| primary-0160 |
 |
primary |
TUBA4A |
AB_477593 |
Anti-α-Tubulin antibody |
| primary-0499 |
 |
primary |
CASP3 |
AB_331439 |
Caspase-3 Antibody |
| primary-0681 |
 |
primary |
HTT |
AB_177645 |
Anti-Huntingtin Protein Antibody |
| primary-0984 |
 |
primary |
ACTB |
AB_306371 |
Anti-beta Actin antibody [mAbcam 8226] - Loading Control |
| primary-1878 |
|
primary |
mCherry |
AB_2333093 |
mCherry Goat Polyclonal Antibody |
| primary-1879 |
|
primary |
PSD95 |
AB_2886821 |
PSD95 antibody |
| primary-1880 |
|
primary |
VGluT1 |
AB_2923539 |
Anti-VGluT1 antibody [N28-9] |
| primary-1881 |
|
primary |
Iba1 |
AB_10972670 |
Anti-Iba1 antibody |
| primary-1882 |
|
primary |
NeuN |
AB_2802653 |
NeuN Monoclonal Antibody (1B7) |
| primary-1883 |
|
primary |
PDE10A |
AB_2927552 |
Anti-PDE10A antibody [EPR22383] |
| primary-1884 |
|
primary |
DARPP32 |
AB_731843 |
Anti-DARPP32 antibody [EP720Y] |
| primary-1885 |
|
primary |
HTT |
AB_10827977 |
Huntingtin (D7F7) XP® Rabbit mAb |