View publication

Publication

Property	Value
Working Groups	RG Fernandez-Busnadiego
Subproject	None
Open Access	Yes
Publication Type	Journal Article
Peer Reviewed	Yes
PMID	39636856
DOI	10.1073/pnas.2417390121
Publication Year	2024
Title	Temporal control of acute protein aggregate turnover by UBE3C and NRF1-dependent proteasomal pathways
Journal	Proceedings of the National Academy of Sciences of the United States of America
ISSN	0027-8424
URL	https://doi.org/10.1073/pnas.2417390121
Issue	50
Volume	121
Journal Abbreviation	Proc Natl Acad Sci U S A
Authors	Hickey KL, Panov A, Whelan EM, Schäfer T, Mizrak A, Kopito RR, Baumeister W, Fernández-Busnadiego R, Harper JW
First Author	Hickey KL
Last Author	Harper JW

External Resources

217306https://www.addgene.org/217306 Addgene identifier (217306, reused)

78289https://www.addgene.org/78289 Addgene identifier (78289, reused)

84832https://www.addgene.org/84832 Addgene identifier (84832, reused)

pnas.org...390121https://www.pnas.org/doi/epdf/10.1073/pnas.2417390121 Article fulltext

10.1007/978-1-4939-8706-1_18https://doi.org/10.1007/978-1-4939-8706-1_18 DOI (10.1007/978-1-4939-8706-1_18, PMID: 30242716, protocol)

10.17504...l5d/v1https://doi.org/10.17504/protocols.io.14egn61xyl5d/v1 DOI (10.17504/protocols.io.14egn61xyl5d/v1, protocols.io)

10.17504...gwz/v1https://doi.org/10.17504/protocols.io.q26g717m8gwz/v1 DOI (10.17504/protocols.io.q26g717m8gwz/v1, protocols.io)

10.17504...lx1/v1https://doi.org/10.17504/protocols.io.rm7vzjej4lx1/v1 DOI (10.17504/protocols.io.rm7vzjej4lx1/v1, protocols.io)

EMD-51460https://www.ebi.ac.uk/pdbe/emdb/EMD-51460 EMBL-EBI EMDB identifier (EMD-51460)

EMD-51461https://www.ebi.ac.uk/pdbe/emdb/EMD-51461 EMBL-EBI EMDB identifier (EMD-51461)

0000-0001-9904-0966https://orcid.org/0000-0001-9904-0966 ORCID identifier (Kelsey L. Hickey)

0000-0002-2960-0291https://orcid.org/0000-0002-2960-0291 ORCID identifier (Alexandra Panov)

0000-0003-1525-7207https://orcid.org/0000-0003-1525-7207 ORCID identifier (Enya Miguel Whelan)

0000-0002-9992-2501https://orcid.org/0000-0002-9992-2501 ORCID identifier (Tillman Schäfer)

0000-0001-6524-4864https://orcid.org/0000-0001-6524-4864 ORCID identifier (Arda Mizrak)

0000-0001-5027-6935https://orcid.org/0000-0001-5027-6935 ORCID identifier (Ron R. Kopito)

0000-0001-8154-8809https://orcid.org/0000-0001-8154-8809 ORCID identifier (Wolfgang Baumeister)

0000-0002-8366-7622https://orcid.org/0000-0002-8366-7622 ORCID identifier (Ruben Fernandez-Busnadiego)

0000-0002-6944-7236https://orcid.org/0000-0002-6944-7236 ORCID identifier (Jeffrey Wade Harper)

PXD055227http://proteomecentral.proteomexchange.org/cgi/GetDataset?ID=PXD055227 Pride proteome dataset (PXD055227)

1/554https://mbexc.uni-goettingen.de/archive/1/554 Research Data Archive (supplemental material)

03zj4c476https://ror.org/03zj4c476 ROR identifier (03zj4c476, Aligning Science Across Parkinson's)

03vek6s52https://ror.org/03vek6s52 ROR identifier (03vek6s52, Harvard University)

04py35477https://ror.org/04py35477 ROR identifier (04py35477, Max Planck Institute of Biochemistry)

05xy1nn52https://ror.org/05xy1nn52 ROR identifier (05xy1nn52, Multiscale Bioimaging)

00f54p054https://ror.org/00f54p054 ROR identifier (00f54p054, Stanford University)

021ft0n22https://ror.org/021ft0n22 ROR identifier (021ft0n22, University Medical Center Göttingen)

01y9bpm73https://ror.org/01y9bpm73 ROR identifier (01y9bpm73, University of Göttingen)

AB_628110https://scicrunch.org/resolver/AB_628110 SciCrunch identifier (RRID:AB_628110)

AB_2241126https://scicrunch.org/resolver/AB_2241126 SciCrunch identifier (RRID:AB_2241126)

AB_2548824https://scicrunch.org/resolver/AB_2548824 SciCrunch identifier (RRID:AB_2548824)

AB_2621371https://scicrunch.org/resolver/AB_2621371 SciCrunch identifier (RRID:AB_2621371)

AB_2651127https://scicrunch.org/resolver/AB_2651127 SciCrunch identifier (RRID:AB_2651127)

AB_2797798https://scicrunch.org/resolver/AB_2797798 SciCrunch identifier (RRID:AB_2797798)

AB_2881429https://scicrunch.org/resolver/AB_2881429 SciCrunch identifier (RRID:AB_2881429)

AB_10538395https://scicrunch.org/resolver/AB_10538395 SciCrunch identifier (RRID:AB_10538395)

AB_10956588https://scicrunch.org/resolver/AB_10956588 SciCrunch identifier (RRID:AB_10956588)

CVCL_0045https://scicrunch.org/resolver/CVCL_0045 SciCrunch identifier (RRID:CVCL_0045, HEK293)

CVCL_0063https://scicrunch.org/resolver/CVCL_0063 SciCrunch identifier (RRID:CVCL_0063, HEK293T)

CVCL_E3BMhttps://scicrunch.org/resolver/CVCL_E3BM SciCrunch identifier (RRID:CVCL_E3BM, HEK293T ADRM1 K21R/K34R agDD-GFP)

CVCL_E3BKhttps://scicrunch.org/resolver/CVCL_E3BK SciCrunch identifier (RRID:CVCL_E3BK, HEK293T UBE3C-/- agDD-GFP)

CVCL_E3BHhttps://scicrunch.org/resolver/CVCL_E3BH SciCrunch identifier (RRID:CVCL_E3BH, HeLa-dCas9)

CVCL_E3BIhttps://scicrunch.org/resolver/CVCL_E3BI SciCrunch identifier (RRID:CVCL_E3BI, HeLa-dCas9 agDD-GFP)

SCR_007358https://scicrunch.org/resolver/SCR_007358 SciCrunch identifier (RRID:SCR_007358, CellProfiler)

SCR_015723https://scicrunch.org/resolver/SCR_015723 SciCrunch identifier (RRID:SCR_015723, CHOPCHOP)

SCR_002285https://scicrunch.org/resolver/SCR_002285 SciCrunch identifier (RRID:SCR_002285, Fiji)

SCR_008520https://scicrunch.org/resolver/SCR_008520 SciCrunch identifier (RRID:SCR_008520, FlowJo)

SCR_002798https://scicrunch.org/resolver/SCR_002798 SciCrunch identifier (RRID:SCR_002798, GraphPad Prism)

SCR_016379https://scicrunch.org/resolver/SCR_016379 SciCrunch identifier (RRID:SCR_016379, Illumina MiSeq System)

SCR_013715https://scicrunch.org/resolver/SCR_013715 SciCrunch identifier (RRID:SCR_013715, Image Studio Lite)

SCR_003297https://scicrunch.org/resolver/SCR_003297 SciCrunch identifier (RRID:SCR_003297, IMOD)

SCR_016499https://scicrunch.org/resolver/SCR_016499 SciCrunch identifier (RRID:SCR_016499, MotionCor2)

SCR_008394https://scicrunch.org/resolver/SCR_008394 SciCrunch identifier (RRID:SCR_008394, Python)

SCR_008058https://scicrunch.org/resolver/SCR_008058 SciCrunch identifier (RRID:SCR_008058, SciPy)

SCR_017293https://scicrunch.org/resolver/SCR_017293 SciCrunch identifier (RRID:SCR_017293, SerialEM)

SCR_018066https://scicrunch.org/resolver/SCR_018066 SciCrunch identifier (RRID:SCR_018066, Sony Biotechnology SH800S Cell Sorter)

SCR_020562https://scicrunch.org/resolver/SCR_020562 SciCrunch identifier (RRID:SCR_020562, Thermo Scientific Orbitrap Fusion Lumos Tribrid Mass Spectrometer)

pnas.org...pp.pdfhttps://www.pnas.org/doi/suppl/10.1073/pnas.2417390121/suppl_file/pnas.2417390121.sapp.pdf Supplemental material

uwpr.github.io/Comet/https://uwpr.github.io/Comet/ Supplemental material (code, reused)

goeseek.gwdguser.de/studies/219https://goeseek.gwdguser.de/studies/219 Supplemental material (goeseek study)

pnas.org...01.mp4https://www.pnas.org/doi/suppl/10.1073/pnas.2417390121/suppl_file/pnas.2417390121.sm01.mp4 Supplemental material (video)

pnas.org...02.mp4https://www.pnas.org/doi/suppl/10.1073/pnas.2417390121/suppl_file/pnas.2417390121.sm02.mp4 Supplemental material (video)

mbexc.de...hways/https://mbexc.de/temporal-control-of-acute-protein-aggregate-turnover-by-ube3c-and-nrf1-dependent-proteasomal-pathways/ Website entry (mbexc.de)

10.5281/zenodo.13625614https://doi.org/10.5281/zenodo.13625614 Zenodo identifier (10.5281/zenodo.13625614)

10.5281/zenodo.13625619https://doi.org/10.5281/zenodo.13625619 Zenodo identifier (10.5281/zenodo.13625619)

10.5281/zenodo.13947535https://doi.org/10.5281/zenodo.13947535 Zenodo identifier (10.5281/zenodo.13947535)

Linked Antibodies

PID	Type	Antigen symbol	Antibody Registry ID	Name
primary-0226	primary	TUBA4A	AB_2241126	Anti-alpha Tubulin antibody
primary-1844	primary	NFE2L1		Anti-NFE2L1 antibody
primary-1845	primary	PCNA	AB_628110	PCNA Antikörper (PC10)
primary-1846	primary	UBE3C	AB_2548824	UBE3C Polyclonal Antibody
primary-1847	primary	UBE3C	AB_2621371	UBE3C Polyclonal Antibody
primary-1849	primary	ADRM1	AB_2797798	ADRM1 (D9Z1U) Rabbit mAb
primary-1850	primary	HSP90	AB_2881429	HSP90 Monoklonaler Antikörper
primary-1851	primary	PSMA3	AB_10538395	Proteasome 20S α7 subunit monoclonal antibody (MCP72)
secondary-1004	secondary		AB_10956588	IRDye® 680RD Goat anti-Mouse IgG Secondary Antibody
secondary-1848	secondary		AB_2651127	IRDye® 800CW Goat anti-Rabbit IgG Secondary Antibody

Technical Support: menoci@medizin.uni-goettingen.de

Department of Medical Informatics
University Medical Center Göttingen
Imprint

View publication

External Resources

Linked Antibodies

Technical support

Links

Spokesperson

Prof. Dr. Tobias Moser

Spokesperson of Cluster of Excellence