| Property |
Value |
| Working Groups |
RG Fernandez-Busnadiego |
| Subproject |
None |
| Open Access |
Yes |
| Publication Type |
Journal Article |
| Peer Reviewed |
Yes |
| PMID |
39636856 |
| DOI |
10.1073/pnas.2417390121 |
| Publication Year |
2024 |
| Title |
Temporal control of acute protein aggregate turnover by UBE3C and NRF1-dependent proteasomal pathways |
| Journal |
Proceedings of the National Academy of Sciences of the United States of America |
| ISSN |
0027-8424 |
| eISSN |
1091-6490 |
| URL |
https://doi.org/10.1073/pnas.2417390121 |
| Issue |
50 |
| Volume |
121 |
| Journal Abbreviation |
Proc Natl Acad Sci U S A |
| Authors |
Hickey KL, Panov A, Whelan EM, Schäfer T, Mizrak A, Kopito RR, Baumeister W, Fernández-Busnadiego R, Harper JW |
| First Author |
Hickey KL |
| Last Author |
Harper JW |
External Resources
217306https://www.addgene.org/217306 Addgene identifier (217306, reused)
78289https://www.addgene.org/78289 Addgene identifier (78289, reused)
84832https://www.addgene.org/84832 Addgene identifier (84832, reused)
pnas.org...390121https://www.pnas.org/doi/epdf/10.1073/pnas.2417390121 Article fulltext
10.1007/978-1-4939-8706-1_18https://doi.org/10.1007/978-1-4939-8706-1_18 DOI (10.1007/978-1-4939-8706-1_18, PMID: 30242716, protocol)
10.17504...l5d/v1https://doi.org/10.17504/protocols.io.14egn61xyl5d/v1 DOI (10.17504/protocols.io.14egn61xyl5d/v1, protocols.io)
10.17504...gwz/v1https://doi.org/10.17504/protocols.io.q26g717m8gwz/v1 DOI (10.17504/protocols.io.q26g717m8gwz/v1, protocols.io)
10.17504...lx1/v1https://doi.org/10.17504/protocols.io.rm7vzjej4lx1/v1 DOI (10.17504/protocols.io.rm7vzjej4lx1/v1, protocols.io)
EMD-51460https://www.ebi.ac.uk/pdbe/emdb/EMD-51460 EMBL-EBI EMDB identifier (EMD-51460)
EMD-51461https://www.ebi.ac.uk/pdbe/emdb/EMD-51461 EMBL-EBI EMDB identifier (EMD-51461)
2/147164https://publications.goettingen-research-online.de/handle/2/147164 GRO.publications identifier
0000-0001-9904-0966https://orcid.org/0000-0001-9904-0966 ORCID identifier (Kelsey L. Hickey)
0000-0002-2960-0291https://orcid.org/0000-0002-2960-0291 ORCID identifier (Alexandra Panov)
0000-0003-1525-7207https://orcid.org/0000-0003-1525-7207 ORCID identifier (Enya Miguel Whelan)
0000-0002-9992-2501https://orcid.org/0000-0002-9992-2501 ORCID identifier (Tillman Schäfer)
0000-0001-6524-4864https://orcid.org/0000-0001-6524-4864 ORCID identifier (Arda Mizrak)
0000-0001-5027-6935https://orcid.org/0000-0001-5027-6935 ORCID identifier (Ron R. Kopito)
0000-0001-8154-8809https://orcid.org/0000-0001-8154-8809 ORCID identifier (Wolfgang Baumeister)
0000-0002-8366-7622https://orcid.org/0000-0002-8366-7622 ORCID identifier (Ruben Fernandez-Busnadiego)
0000-0002-6944-7236https://orcid.org/0000-0002-6944-7236 ORCID identifier (Jeffrey Wade Harper)
PXD055227http://proteomecentral.proteomexchange.org/cgi/GetDataset?ID=PXD055227 Pride proteome dataset (PXD055227)
1/554https://mbexc.uni-goettingen.de/archive/1/554 Research Data Archive (supplemental material)
03zj4c476https://ror.org/03zj4c476 ROR identifier (03zj4c476, Aligning Science Across Parkinson's)
03vek6s52https://ror.org/03vek6s52 ROR identifier (03vek6s52, Harvard University)
04py35477https://ror.org/04py35477 ROR identifier (04py35477, Max Planck Institute of Biochemistry)
05xy1nn52https://ror.org/05xy1nn52 ROR identifier (05xy1nn52, Multiscale Bioimaging)
00f54p054https://ror.org/00f54p054 ROR identifier (00f54p054, Stanford University)
021ft0n22https://ror.org/021ft0n22 ROR identifier (021ft0n22, University Medical Center Göttingen)
01y9bpm73https://ror.org/01y9bpm73 ROR identifier (01y9bpm73, University of Göttingen)
AB_628110https://scicrunch.org/resolver/AB_628110 SciCrunch identifier (RRID:AB_628110)
AB_2241126https://scicrunch.org/resolver/AB_2241126 SciCrunch identifier (RRID:AB_2241126)
AB_2548824https://scicrunch.org/resolver/AB_2548824 SciCrunch identifier (RRID:AB_2548824)
AB_2621371https://scicrunch.org/resolver/AB_2621371 SciCrunch identifier (RRID:AB_2621371)
AB_2651127https://scicrunch.org/resolver/AB_2651127 SciCrunch identifier (RRID:AB_2651127)
AB_2797798https://scicrunch.org/resolver/AB_2797798 SciCrunch identifier (RRID:AB_2797798)
AB_2881429https://scicrunch.org/resolver/AB_2881429 SciCrunch identifier (RRID:AB_2881429)
AB_10538395https://scicrunch.org/resolver/AB_10538395 SciCrunch identifier (RRID:AB_10538395)
AB_10956588https://scicrunch.org/resolver/AB_10956588 SciCrunch identifier (RRID:AB_10956588)
CVCL_0045https://scicrunch.org/resolver/CVCL_0045 SciCrunch identifier (RRID:CVCL_0045, HEK293)
CVCL_0063https://scicrunch.org/resolver/CVCL_0063 SciCrunch identifier (RRID:CVCL_0063, HEK293T)
CVCL_E3BMhttps://scicrunch.org/resolver/CVCL_E3BM SciCrunch identifier (RRID:CVCL_E3BM, HEK293T ADRM1 K21R/K34R agDD-GFP)
CVCL_E3BKhttps://scicrunch.org/resolver/CVCL_E3BK SciCrunch identifier (RRID:CVCL_E3BK, HEK293T UBE3C-/- agDD-GFP)
CVCL_E3BHhttps://scicrunch.org/resolver/CVCL_E3BH SciCrunch identifier (RRID:CVCL_E3BH, HeLa-dCas9)
CVCL_E3BIhttps://scicrunch.org/resolver/CVCL_E3BI SciCrunch identifier (RRID:CVCL_E3BI, HeLa-dCas9 agDD-GFP)
SCR_007358https://scicrunch.org/resolver/SCR_007358 SciCrunch identifier (RRID:SCR_007358, CellProfiler)
SCR_015723https://scicrunch.org/resolver/SCR_015723 SciCrunch identifier (RRID:SCR_015723, CHOPCHOP)
SCR_002285https://scicrunch.org/resolver/SCR_002285 SciCrunch identifier (RRID:SCR_002285, Fiji)
SCR_008520https://scicrunch.org/resolver/SCR_008520 SciCrunch identifier (RRID:SCR_008520, FlowJo)
SCR_002798https://scicrunch.org/resolver/SCR_002798 SciCrunch identifier (RRID:SCR_002798, GraphPad Prism)
SCR_016379https://scicrunch.org/resolver/SCR_016379 SciCrunch identifier (RRID:SCR_016379, Illumina MiSeq System)
SCR_013715https://scicrunch.org/resolver/SCR_013715 SciCrunch identifier (RRID:SCR_013715, Image Studio Lite)
SCR_003297https://scicrunch.org/resolver/SCR_003297 SciCrunch identifier (RRID:SCR_003297, IMOD)
SCR_016499https://scicrunch.org/resolver/SCR_016499 SciCrunch identifier (RRID:SCR_016499, MotionCor2)
SCR_008394https://scicrunch.org/resolver/SCR_008394 SciCrunch identifier (RRID:SCR_008394, Python)
SCR_008058https://scicrunch.org/resolver/SCR_008058 SciCrunch identifier (RRID:SCR_008058, SciPy)
SCR_017293https://scicrunch.org/resolver/SCR_017293 SciCrunch identifier (RRID:SCR_017293, SerialEM)
SCR_018066https://scicrunch.org/resolver/SCR_018066 SciCrunch identifier (RRID:SCR_018066, Sony Biotechnology SH800S Cell Sorter)
SCR_020562https://scicrunch.org/resolver/SCR_020562 SciCrunch identifier (RRID:SCR_020562, Thermo Scientific Orbitrap Fusion Lumos Tribrid Mass Spectrometer)
pnas.org...pp.pdfhttps://www.pnas.org/doi/suppl/10.1073/pnas.2417390121/suppl_file/pnas.2417390121.sapp.pdf Supplemental material
uwpr.github.io/Comet/https://uwpr.github.io/Comet/ Supplemental material (code, reused)
goeseek.gwdguser.de/studies/219https://goeseek.gwdguser.de/studies/219 Supplemental material (goeseek study)
pnas.org...01.mp4https://www.pnas.org/doi/suppl/10.1073/pnas.2417390121/suppl_file/pnas.2417390121.sm01.mp4 Supplemental material (video)
pnas.org...02.mp4https://www.pnas.org/doi/suppl/10.1073/pnas.2417390121/suppl_file/pnas.2417390121.sm02.mp4 Supplemental material (video)
mbexc.de...hways/https://mbexc.de/temporal-control-of-acute-protein-aggregate-turnover-by-ube3c-and-nrf1-dependent-proteasomal-pathways/ Website entry (mbexc.de)
10.5281/zenodo.13625614https://doi.org/10.5281/zenodo.13625614 Zenodo identifier (10.5281/zenodo.13625614)
10.5281/zenodo.13625619https://doi.org/10.5281/zenodo.13625619 Zenodo identifier (10.5281/zenodo.13625619)
10.5281/zenodo.13947535https://doi.org/10.5281/zenodo.13947535 Zenodo identifier (10.5281/zenodo.13947535)
Linked Antibodies
| PID |
AG |
Type |
Antigen symbol |
Antibody Registry ID |
Name |
| primary-0226 |
 |
primary |
TUBA4A |
AB_2241126 |
Anti-alpha Tubulin antibody |
| primary-1844 |
|
primary |
NFE2L1 |
|
Anti-NFE2L1 antibody |
| primary-1845 |
|
primary |
PCNA |
AB_628110 |
PCNA Antikörper (PC10) |
| primary-1846 |
|
primary |
UBE3C |
AB_2548824 |
UBE3C Polyclonal Antibody |
| primary-1847 |
|
primary |
UBE3C |
AB_2621371 |
UBE3C Polyclonal Antibody |
| primary-1849 |
|
primary |
ADRM1 |
AB_2797798 |
ADRM1 (D9Z1U) Rabbit mAb |
| primary-1850 |
|
primary |
HSP90 |
AB_2881429 |
HSP90 Monoklonaler Antikörper |
| primary-1851 |
|
primary |
PSMA3 |
AB_10538395 |
Proteasome 20S α7 subunit monoclonal antibody (MCP72) |
| secondary-1004 |
|
secondary |
|
AB_10956588 |
IRDye® 680RD Goat anti-Mouse IgG Secondary Antibody |
| secondary-1848 |
|
secondary |
|
AB_2651127 |
IRDye® 800CW Goat anti-Rabbit IgG Secondary Antibody |