| Property |
Value |
| Working Groups |
RG Fernandez-Busnadiego |
| Subproject |
None |
| Open Access |
Yes |
| Publication Type |
Journal Article |
| Peer Reviewed |
Yes |
| PMID |
38848361 |
| DOI |
10.1126/sciadv.adn7191 |
| Publication Year |
2024 |
| Title |
Mechanism of human PINK1 activation at the TOM complex in a reconstituted system |
| Journal |
Science Advances |
| ISSN |
2375-2548 |
| URL |
http://dx.doi.org/10.1126/sciadv.adn7191 |
| Issue |
23 |
| Volume |
10 |
| Journal Abbreviation |
Sci Adv |
| Authors |
Raimi OG, Ojha H, Ehses K, Dederer V, Lange SM, Rivera CP, Deegan TD, Chen Y, Wightman M, Toth R, Labib KPM, Mathea S, Ranson N, Fernández-Busnadiego R, Muqit MMK |
| First Author |
Raimi OG |
| Last Author |
Muqit MMK |
External Resources
218680https://www.addgene.org/218680 Addgene identifier (218680, reused)
10.17504...v4o/v1https://doi.org/10.17504/protocols.io.5qpvo3mezv4o/v1 DOI (10.17504/protocols.io.5qpvo3mezv4o/v1, protocols.io)
10.17504/protocols.io.bsgrnbv6https://doi.org/10.17504/protocols.io.bsgrnbv6 DOI (10.17504/protocols.io.bsgrnbv6, protocols.io)
10.17504...vzp/v1https://doi.org/10.17504/protocols.io.dm6gp3p71vzp/v1 DOI (10.17504/protocols.io.dm6gp3p71vzp/v1, protocols.io)
10.17504...l8j/v1https://doi.org/10.17504/protocols.io.kxygxyk9dl8j/v1 DOI (10.17504/protocols.io.kxygxyk9dl8j/v1, protocols.io)
10.17504...lk5/v1https://doi.org/10.17504/protocols.io.n2bvj37kwlk5/v1 DOI (10.17504/protocols.io.n2bvj37kwlk5/v1, protocols.io)
10.17504...lk5/v1https://doi.org/10.17504/protocols.io.n2bvj3mxxlk5/v1 DOI (10.17504/protocols.io.n2bvj3mxxlk5/v1, protocols.io)
2/143910https://publications.goettingen-research-online.de/handle/2/143910 GRO.publications identifier
7108https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=7108 NCBI taxonomy (fall armyworm, Spodoptera frugiperda)
9606https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 NCBI taxonomy (human, Homo sapiens)
4932https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=4932 NCBI taxonomy (yeast, Saccharomyces cerevisiae)
0000-0003-2782-7318https://orcid.org/0000-0003-2782-7318 ORCID identifier (Olawale G. Raimi)
0000-0002-8595-5994https://orcid.org/0000-0002-8595-5994 ORCID identifier (Kenneth Ehses)
0000-0002-6011-8647https://orcid.org/0000-0002-6011-8647 ORCID identifier (Sven M. Lange)
0009-0006-7557-5388https://orcid.org/0009-0006-7557-5388 ORCID identifier (Verena Dederer)
0000-0002-1433-4111https://orcid.org/0000-0002-1433-4111 ORCID identifier (Cristian Polo Rivera)
0000-0002-1337-0612https://orcid.org/0000-0002-1337-0612 ORCID identifier (Rachel Toth)
0000-0001-8861-379Xhttps://orcid.org/0000-0001-8861-379X ORCID identifier (Karim P. M. Labib)
0000-0001-8500-4569https://orcid.org/0000-0001-8500-4569 ORCID identifier (Sebastian Mathea)
0000-0002-3640-5275https://orcid.org/0000-0002-3640-5275 ORCID identifier (Neil A. Ranson)
0000-0002-8366-7622https://orcid.org/0000-0002-8366-7622 ORCID identifier (Ruben Fernandez-Busnadiego)
0000-0001-9733-2404https://orcid.org/0000-0001-9733-2404 ORCID identifier (Miratul M. K. Muqit)
1010https://prod.mbexc.uni-goettingen.de/literature/publications/1010 Published Data Registry entry (MBExC, Live Cell Imaging Protocol)
917https://prod.mbexc.uni-goettingen.de/literature/publications/917 Published Data Registry entry (MBExC, preprint)
1/463https://mbexc.uni-goettingen.de/archive/1/463 Research Data Archive (supplemental material)
03zj4c476https://ror.org/03zj4c476 ROR identifier (03zj4c476, Aligning Science Across Parkinson's)
04cvxnb49https://ror.org/04cvxnb49 ROR identifier (04cvxnb49, Goethe University Frankfurt)
05xy1nn52https://ror.org/05xy1nn52 ROR identifier (05xy1nn52, Multiscale Bioimaging)
021ft0n22https://ror.org/021ft0n22 ROR identifier (021ft0n22, University Medical Center Göttingen)
03h2bxq36https://ror.org/03h2bxq36 ROR identifier (03h2bxq36, University of Dundee)
01nrxwf90https://ror.org/01nrxwf90 ROR identifier (01nrxwf90, University of Edinburgh)
01y9bpm73https://ror.org/01y9bpm73 ROR identifier (01y9bpm73, University of Göttingen)
024mrxd33https://ror.org/024mrxd33 ROR identifier (024mrxd33, University of Leeds)
009kr6r15https://ror.org/009kr6r15 ROR identifier (009kr6r15, Western General Hospital)
CVCL_0030https://scicrunch.org/resolver/CVCL_0030 SciCrunch identifier (RRID:CVCL_0030, HeLa)
CVCL_D5JIhttps://scicrunch.org/resolver/CVCL_D5JI SciCrunch identifier (RRID:CVCL_D5JI, HeLa Flp-In T-REx PINK1 KO clone 3C9)
SCR_023662https://scicrunch.org/resolver/SCR_023662 SciCrunch identifier (RRID:SCR_023662, AlphaFold Protein Structure Database)
SCR_016151https://scicrunch.org/resolver/SCR_016151 SciCrunch identifier (RRID:SCR_016151, AMBER)
SCR_013673https://scicrunch.org/resolver/SCR_013673 SciCrunch identifier (RRID:SCR_013673, Leica Application Suite X)
SCR_023794https://scicrunch.org/resolver/SCR_023794 SciCrunch identifier (RRID:SCR_023794, Leica Thunder Imager Live Cell system)
SCR_000305https://scicrunch.org/resolver/SCR_000305 SciCrunch identifier (RRID:SCR_000305, PyMOL)
science....sm.pdfhttps://www.science.org/doi/suppl/10.1126/sciadv.adn7191/suppl_file/sciadv.adn7191_sm.pdf Supplemental material
science....s4.ziphttps://www.science.org/doi/suppl/10.1126/sciadv.adn7191/suppl_file/sciadv.adn7191_tables_s1_to_s4.zip Supplemental material (table)
science....s1.ziphttps://www.science.org/doi/suppl/10.1126/sciadv.adn7191/suppl_file/sciadv.adn7191_movie_s1.zip Supplemental material (video)
mbexc.de...ystem/https://mbexc.de/mechanism-of-human-pink1-activation-at-the-tom-complex-in-a-reconstituted-system/ Website entry (mbexc.de)
10.5281/zenodo.10792792https://doi.org/10.5281/zenodo.10792792 Zenodo identifier (10.5281/zenodo.10792792)
10.5281/zenodo.10829882https://doi.org/10.5281/zenodo.10829882 Zenodo identifier (10.5281/zenodo.10829882)
10.5281/zenodo.11060950https://doi.org/10.5281/zenodo.11060950 Zenodo identifier (10.5281/zenodo.11060950)
10.5281/zenodo.11065259https://doi.org/10.5281/zenodo.11065259 Zenodo identifier (10.5281/zenodo.11065259)
10.5281/zenodo.11065277https://doi.org/10.5281/zenodo.11065277 Zenodo identifier (10.5281/zenodo.11065277)
Linked Antibodies
| PID |
AG |
Type |
Antigen symbol |
Antibody Registry ID |
Name |
| primary-0320 |
 |
primary |
GAPDH |
AB_627679 |
Anti-GAPDH Antibody |
| primary-1416 |
|
primary |
CDC28 |
AB_671808 |
Cdc28 Antikörper (yC-20) |
| primary-1417 |
|
primary |
PINK1 |
AB_526188 |
PINK1 Antibody - BSA Free |
| primary-1418 |
|
primary |
OPA1 |
AB_399888 |
Purified Mouse Anti-OPA1 |
| primary-1468 |
|
primary |
PINK1 |
AB_3095414 |
Anti-PINK1 Antibody |
| primary-1469 |
|
primary |
UBA52 |
AB_2799632 |
Phospho-Ubiquitin (Ser65) (E2J6T) Rabbit mAb #62802 |
| primary-1470 |
|
primary |
Tom20 |
AB_628381 |
Tom20 Antikörper (F-10) |
| primary-1471 |
|
primary |
TOMM22 |
AB_3095411 |
Anti-TOMM22/TOM22 antibody [EPR13505] - N-terminal |
| primary-1472 |
|
primary |
TOM40 |
AB_3095412 |
Anti-TOMM40 antibody [EPR6932(2)] |
| primary-1473 |
|
primary |
TOMM70 |
AB_3095413 |
TOMM70 Antibody |
| primary-1474 |
|
primary |
TOMM7 |
AB_3095485 |
TOMM7 (1 - 55) |
| primary-1475 |
|
primary |
TOMM6 |
AB_3095484 |
TOMM6 (1 - 74) |
| primary-1476 |
|
primary |
Anti-6X |
AB_3095553 |
Monoclonal Anti-6X His tag antibody produced in mouse |