| Property |
Value |
| Working Groups |
RG Rehling |
| Subproject |
None |
| Open Access |
Yes |
| Publication Type |
Journal Article |
| Peer Reviewed |
Yes |
| PMID |
37860693 |
| DOI |
10.1016/j.isci.2023.108080 |
| Publication Year |
2023 |
| Title |
The SARS-CoV-2 protein ORF3c is a mitochondrial modulator of innate immunity |
| Journal |
iScience |
| eISSN |
2589-0042 |
| URL |
http://dx.doi.org/10.1016/j.isci.2023.108080 |
| Pages |
108080 |
| Issue |
11 |
| Volume |
26 |
| Journal Abbreviation |
iScience |
| Authors |
Stewart H, Lu Y, O’Keefe S, Valpadashi A, Cruz-Zaragoza LD, Michel HA, Nguyen SK, Carnell GW, Lukhovitskaya N, Milligan R, Adewusi Y, Jungreis I, Lulla V, Matthews DA, High S, Rehling P, Emmott E, Heeney JL, Davidson AD, Edgar JR, Smith GL, Firth AE |
| First Author |
Stewart H |
| Last Author |
Firth AE |
External Resources
208653https://www.addgene.org/208653 Addgene identifier (208653)
208728https://www.addgene.org/208728 Addgene identifier (208728)
208729https://www.addgene.org/208729 Addgene identifier (208729)
cell.com...2157-0https://www.cell.com/action/showPdf?pii=S2589-0042%2823%2902157-0 Article fulltext
2/138654https://publications.goettingen-research-online.de/handle/2/138654 GRO.publications identifier
MW041156.1https://www.ncbi.nlm.nih.gov/nuccore/MW041156.1 NCBI nucleotide (MW041156.1, reused)
9606https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 NCBI taxonomy (human, Homo sapiens)
0000-0003-1438-1089https://orcid.org/0000-0003-1438-1089 ORCID identifier (Hazel Stewart)
0000-0002-1744-0198https://orcid.org/0000-0002-1744-0198 ORCID identifier (Sarah O'Keefe)
0000-0001-9568-0245https://orcid.org/0000-0001-9568-0245 ORCID identifier (Luis Daniel Cruz-Zaragoza)
0000-0001-7025-5605https://orcid.org/0000-0001-7025-5605 ORCID identifier (Hendrik A. Michel)
0000-0001-8875-0989https://orcid.org/0000-0001-8875-0989 ORCID identifier (George William Carnell)
0000-0001-5968-6762https://orcid.org/0000-0001-5968-6762 ORCID identifier (Nina Lukhovitskaya)
0000-0002-3197-5367https://orcid.org/0000-0002-3197-5367 ORCID identifier (Irwin Jungreis)
0000-0002-6605-0727https://orcid.org/0000-0002-6605-0727 ORCID identifier (Valeria Lulla)
0000-0003-4611-8795https://orcid.org/0000-0003-4611-8795 ORCID identifier (David A. Matthews)
0000-0002-4532-8152https://orcid.org/0000-0002-4532-8152 ORCID identifier (Stephen High)
0000-0001-5661-5272https://orcid.org/0000-0001-5661-5272 ORCID identifier (Peter Rehling)
0000-0002-3239-8178https://orcid.org/0000-0002-3239-8178 ORCID identifier (Edward Emmott)
0000-0003-2702-1621https://orcid.org/0000-0003-2702-1621 ORCID identifier (Jonathan Luke Heeney)
0000-0002-1136-4008https://orcid.org/0000-0002-1136-4008 ORCID identifier (Andrew D. Davidson)
0000-0001-7903-8199https://orcid.org/0000-0001-7903-8199 ORCID identifier (James R. Edgar)
0000-0002-3730-9955https://orcid.org/0000-0002-3730-9955 ORCID identifier (Geoffrey L. Smith)
0000-0002-7986-9520https://orcid.org/0000-0002-7986-9520 ORCID identifier (Andrew E. Firth)
PXD037765http://proteomecentral.proteomexchange.org/cgi/GetDataset?ID=PXD037765 Pride proteome dataset (PXD037765)
245https://sfb1190.med.uni-goettingen.de/production/literature/publications/245 Published Data Registry entry (CRC 1190)
626https://prod.mbexc.uni-goettingen.de/literature/publications/626 Published Data Registry entry (MBExC, preprint)
03vek6s52https://ror.org/03vek6s52 ROR identifier (03vek6s52, Harvard University)
05xy1nn52https://ror.org/05xy1nn52 ROR identifier (05xy1nn52, Multiscale Bioimaging)
021ft0n22https://ror.org/021ft0n22 ROR identifier (021ft0n22, University Medical Center Göttingen)
0524sp257https://ror.org/0524sp257 ROR identifier (0524sp257, University of Bristol)
013meh722https://ror.org/013meh722 ROR identifier (013meh722, University of Cambridge)
04xs57h96https://ror.org/04xs57h96 ROR identifier (04xs57h96, University of Liverpool)
027m9bs27https://ror.org/027m9bs27 ROR identifier (027m9bs27, University of Manchester)
CVCL_0023https://scicrunch.org/resolver/CVCL_0023 SciCrunch identifier (RRID:CVCL_0023, A-549)
CVCL_U421https://scicrunch.org/resolver/CVCL_U421 SciCrunch identifier (RRID:CVCL_U421, Flp-In-293)
CVCL_0063https://scicrunch.org/resolver/CVCL_0063 SciCrunch identifier (RRID:CVCL_0063, HEK293T)
CVCL_0030https://scicrunch.org/resolver/CVCL_0030 SciCrunch identifier (RRID:CVCL_0030, HeLa)
CVCL_0574https://scicrunch.org/resolver/CVCL_0574 SciCrunch identifier (RRID:CVCL_0574, Vero C1008)
SCR_002798https://scicrunch.org/resolver/SCR_002798 SciCrunch identifier (RRID:SCR_002798, GraphPad Prism)
SCR_001622https://scicrunch.org/resolver/SCR_001622 SciCrunch identifier (RRID:SCR_001622, MATLAB)
SCR_015052https://scicrunch.org/resolver/SCR_015052 SciCrunch identifier (RRID:SCR_015052, SnapGene)
SCR_013715https://scicrunch.org/resolver/SCR_013715 SciCrunch identifier (RRID:SCR_013715, Image Studio Lite)
gisaid.org/EPI_SET_221101zchttp://gisaid.org/EPI_SET_221101zc Supplemental material (data, reused)
cell.com...c1.pdfhttps://www.cell.com/cms/10.1016/j.isci.2023.108080/attachment/a132b15a-00da-4c81-bd2c-c32295cbc09f/mmc1.pdf Supplemental material (figure)
cell.com...2.xlsxhttps://www.cell.com/cms/10.1016/j.isci.2023.108080/attachment/4c880d5e-6cd6-426d-88fc-0f6102a5ff59/mmc2.xlsx Supplemental material (table)
cell.com...3.xlsxhttps://www.cell.com/cms/10.1016/j.isci.2023.108080/attachment/928a971a-f458-4035-8f08-0bf2bf667cb2/mmc3.xlsx Supplemental material (table)
mbexc.de...unity/https://mbexc.de/the-sars-cov-2-protein-orf3c-is-a-mitochondrial-modulator-of-innate-immunity/ Website entry (mbexc.de)
Linked Antibodies
| PID |
AG |
Type |
Antigen symbol |
Antibody Registry ID |
Name |
| primary-0510 |
 |
primary |
Strep |
AB_513133 |
StrepMAB-Classic |
| primary-0769 |
 |
primary |
STX6 |
AB_2196500 |
Syntaxin 6 (C34B2) Rabbit mAb |
| primary-0901 |
|
primary |
TIMM22 |
AB_11183050 |
TIM22 Polyclonal antibody |
| primary-1065 |
|
primary |
FLAG |
AB_439687 |
ANTI-FLAG® antibody |
| primary-1570 |
|
primary |
HA.11 |
AB_2565006 |
Purified anti-HA.11 Epitope Tag Antibody |
| primary-1571 |
|
primary |
ACTC |
AB_476693 |
Anti-Actin antibody produced in rabbit |
| primary-1573 |
|
primary |
HA |
AB_445319 |
Anti-HA tag antibody |
| primary-1574 |
|
primary |
TUBB3 |
AB_2210952 |
Anti-beta Tubulin antibody |
| primary-1575 |
|
primary |
VDAC1 |
AB_443084 |
Anti-VDAC1/Porin + VDAC3 antibody [20B12AF2] |
| primary-1576 |
|
primary |
LMNA |
AB_2813767 |
Anti-Lamin A + Lamin C antibody [EP4520-16] |
| primary-1577 |
|
primary |
TOMM20 |
|
Anti-TOMM20 antibody [EPR15581-39] - Mouse IgG1 (Chimeric) |
| primary-1578 |
|
primary |
TOMM70A |
AB_2303727 |
TOM70 Polyklonaler Antikörper |
| primary-1579 |
|
primary |
TUBA1B |
AB_11042766 |
Alpha Tubulin Monoklonaler Antikörper |
| primary-1580 |
|
primary |
TGN46 |
AB_2203289 |
Anti-TGN46 antibody |
| primary-1591 |
|
primary |
MAVS |
|
MAVS Antibody |
| primary-1592 |
|
primary |
FLAG |
AB_796202 |
Monoclonal ANTI-FLAG® antibody produced in rabbit |
| primary-1596 |
|
primary |
ERLIN2 |
AB_2098859 |
ERLIN2 Polyclonal antibody |
| secondary-0276 |
 |
secondary |
|
AB_2534069 |
Goat anti-Mouse IgG (H+L) Cross-Adsorbed Secondary Antibody, Alexa Fluor 488 |
| secondary-0869 |
|
secondary |
|
AB_10954442 |
IRDye® 680RD Donkey anti-Rabbit IgG Secondary Antibody |
| secondary-1005 |
|
secondary |
|
AB_621843 |
IRDye® 800CW Goat anti-Rabbit IgG Secondary Antibody |
| secondary-1042 |
 |
secondary |
|
AB_10953628 |
IRDye® 680RD Donkey anti-Mouse IgG Secondary Antibody |
| secondary-1538 |
 |
secondary |
|
AB_621842 |
IRDye® 800CW Goat anti-Mouse IgG Secondary Antibody |
| secondary-1572 |
|
secondary |
|
AB_10956736 |
IRDye® 680RD Donkey anti-Goat IgG Secondary Antibody |
| secondary-1593 |
|
secondary |
|
AB_2534074 |
Goat anti-Rat IgG (H+L) Cross-Adsorbed Secondary Antibody, Alexa Fluor™ 488 |
| secondary-1594 |
|
secondary |
|
AB_2534082 |
Donkey anti-Sheep IgG (H+L) Cross-Adsorbed Secondary Antibody, Alexa Fluor™ 488 |
| secondary-1595 |
|
secondary |
|
AB_2633281 |
Goat anti-Rabbit IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor™ Plus 555 |