| Property |
Value |
| Working Groups |
RG Gollisch, 
RG Möbius, 
RG Outeiro, 
RG Urlaub |
| Subproject |
RA2.2 |
| Open Access |
Yes |
| Publication Type |
Preprint |
| Peer Reviewed |
No |
| DOI |
10.1101/2021.07.18.452825 |
| Publication Year |
2021 |
| Title |
Common molecular mechanisms underlie the transfer of alpha-synuclein, Tau and huntingtin and modulate spontaneous activity in neuronal cells |
| Journal |
bioRxiv |
| eISSN |
2692-8205 |
| URL |
http://dx.doi.org/10.1101/2021.07.18.452825 |
| Journal Abbreviation |
bioRxiv |
| Extra |
Final article published in Journal of Parkinson's Disease here: doi:10.3233/jpd-223516 |
| Authors |
Brás IC, Khani MH, Vasili E, Möbius W, Riedel D, Parfentev I, Gerhardt E, Fahlbusch C, Urlaub H, Zweckstetter M, Gollisch T, Outeiro TF |
| First Author |
Brás IC |
| Last Author |
Outeiro TF |
External Resources
biorxiv....ll.pdfhttps://www.biorxiv.org/content/10.1101/2021.07.18.452825v1.full.pdf Article fulltext
2/100391https://publications.goettingen-research-online.de/handle/2/100391 GRO.publications identifier
10090https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10090 NCBI taxonomy (mouse, Mus musculus)
0000-0001-8451-8891https://orcid.org/0000-0001-8451-8891 ORCID identifier (Ines Caldeira Bras)
0000-0003-3123-7054https://orcid.org/0000-0003-3123-7054 ORCID identifier (Mohammad Hossein Khani)
0000-0001-9150-0104https://orcid.org/0000-0001-9150-0104 ORCID identifier (Eftychia Vasili)
0000-0002-2902-7165https://orcid.org/0000-0002-2902-7165 ORCID identifier (Wiebke Möbius)
0000-0003-2970-6894https://orcid.org/0000-0003-2970-6894 ORCID identifier (Dietmar Riedel)
0000-0002-0203-2167https://orcid.org/0000-0002-0203-2167 ORCID identifier (Iwan Parfentev)
0000-0003-1837-5233https://orcid.org/0000-0003-1837-5233 ORCID identifier (Henning Urlaub)
0000-0002-2536-6581https://orcid.org/0000-0002-2536-6581 ORCID identifier (Markus Zweckstetter)
0000-0003-3998-533Xhttps://orcid.org/0000-0003-3998-533X ORCID identifier (Tim Gollisch)
0000-0003-1679-1727https://orcid.org/0000-0003-1679-1727 ORCID identifier (Tiago Fleming Outeiro)
128https://sfb1286.uni-goettingen.de/literature/publications/128 Published Data Registry entry (CRC 1286)
652https://prod.mbexc.uni-goettingen.de/literature/publications/652 Published Data Registry entry (MBExC, final article)
1/368https://mbexc.uni-goettingen.de/archive/1/368 Research Data Archive (supplemental material)
043j0f473https://ror.org/043j0f473 ROR identifier (043j0f473, German Center for Neurodegenerative Diseases)
03e76ya46https://ror.org/03e76ya46 ROR identifier (03e76ya46, Max Planck Institute for Biophysical Chemistry)
04a7f6w43https://ror.org/04a7f6w43 ROR identifier (04a7f6w43, Max Planck Institute of Experimental Medicine)
05xy1nn52https://ror.org/05xy1nn52 ROR identifier (05xy1nn52, Multiscale Bioimaging)
01kj2bm70https://ror.org/01kj2bm70 ROR identifier (01kj2bm70, Newcastle University)
021ft0n22https://ror.org/021ft0n22 ROR identifier (021ft0n22, University Medical Center Göttingen)
SCR_008520https://scicrunch.org/resolver/SCR_008520 SciCrunch identifier (RRID:SCR_008520, FlowJo)
SCR_002798https://scicrunch.org/resolver/SCR_002798 SciCrunch identifier (RRID:SCR_002798, GraphPad Prism)
SCR_003070https://scicrunch.org/resolver/SCR_003070 SciCrunch identifier (RRID:SCR_003070, ImageJ)
SCR_016422https://scicrunch.org/resolver/SCR_016422 SciCrunch identifier (RRID:SCR_016422, KiloSort)
SCR_013673https://scicrunch.org/resolver/SCR_013673 SciCrunch identifier (RRID:SCR_013673, Leica Application Suite X)
SCR_001622https://scicrunch.org/resolver/SCR_001622 SciCrunch identifier (RRID:SCR_001622, MATLAB)
SCR_015753https://scicrunch.org/resolver/SCR_015753 SciCrunch identifier (RRID:SCR_015753, Perseus)
biorxiv....d=truehttps://www.biorxiv.org/content/biorxiv/early/2021/07/19/2021.07.18.452825/DC1/embed/media-1.pdf?download=true Supplemental material
mbexc.de...cells/https://mbexc.de/common-molecular-mechanisms-underlie-the-transfer-of-alpha-synuclein-tau-and-huntingtinand-modulate-spontaneous-activityin-neuronal-cells/ Website entry (mbexc.de)
Linked Antibodies
| PID |
AG |
Type |
Antigen symbol |
Antibody Registry ID |
Name |
| primary-0280 |
 |
primary |
GFAP |
AB_10013382 |
Glial Fibrillary Acidic Protein (Multipurpose) antibody |
| primary-0367 |
 |
primary |
SNCA |
AB_869973 |
Recombinant Anti-Alpha-synuclein (phospho S129) antibody |
| primary-0368 |
|
primary |
SNCA |
AB_398108 |
a-Synuclein antibody |
| primary-0384 |
 |
primary |
TAU |
AB_10013724 |
Polyclonal Rabbit Anti-Human Tau |
| primary-0385 |
|
primary |
ACTB |
AB_476744 |
Monoclonal Anti-β-Actin antibody |
| primary-0389 |
|
primary |
MAPT |
AB_2314654 |
Tau Monoclonal Antibody |
| primary-0680 |
|
primary |
TUBA1A |
AB_2212272 |
Alpha-Tubulin antibody |
| primary-0681 |
|
primary |
HTT |
AB_177645 |
Anti-Huntingtin Protein Antibody |
| primary-0682 |
|
primary |
AIF1 |
AB_2224402 |
Anti-Iba1 antibody |
| primary-0683 |
|
primary |
LC3 |
AB_2274121 |
Anti-LC3 pAb |
| primary-0684 |
|
primary |
MAP2 |
AB_297885 |
Anti-MAP2 antibody |
| primary-0685 |
|
primary |
SYP |
AB_887905 |
Synaptophysin 1 antibody |
| primary-0780 |
|
primary |
PDCD6IP |
AB_10899268 |
Anti-ALIX antibody |
| primary-0781 |
|
primary |
ANXA2 |
|
Recombinant Anti-Annexin-2/ANXA2 antibody |
| primary-0782 |
|
primary |
AGE |
AB_447638 |
Anti-AGE antibody |
| primary-0783 |
|
primary |
FLOT1 |
AB_2773040 |
Flotillin-1 (D2V7J) XP® Rabbit mAb |
| primary-0784 |
|
primary |
GFP |
AB_390913 |
Anti-GFP antibody |
| primary-0785 |
|
primary |
NOS2 |
AB_310179 |
Anti-iNOS/NOS II Antibody |
| primary-0786 |
|
primary |
AIF1 |
AB_2636859 |
Recombinant Anti-Iba1 antibody |
| primary-0787 |
|
primary |
SQSTM1 |
AB_2050336 |
Anti-SQSTM1 / p62 antibody |
| primary-0788 |
|
primary |
USP19 KIAA0891 |
AB_1078839 |
USP19/ZMYND9 Antibody |
| secondary-0021 |
|
secondary |
|
AB_2534102 |
Donkey anti-Goat IgG (H+L) Cross-Adsorbed Secondary Antibody, Alexa Fluor 488 |
| secondary-0022 |
|
secondary |
|
AB_2535853 |
Donkey anti-Goat IgG (H+L) Cross-Adsorbed Secondary Antibody, Alexa Fluor 555 |
| secondary-0392 |
|
secondary |
|
AB_2535792 |
Donkey anti-Rabbit IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor 488 |
| secondary-0394 |
|
secondary |
|
AB_141607 |
Donkey anti-Mouse IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor 488 |
| secondary-0477 |
 |
secondary |
|
AB_162543 |
Donkey anti-Rabbit IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor 555 |
| secondary-0491 |
|
secondary |
|
AB_2536180 |
Donkey anti-Mouse IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor 555 |
| secondary-0571 |
 |
secondary |
|
AB_2535794 |
Donkey anti-Rat IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor 488 |
| secondary-0686 |
|
secondary |
|
AB_2535718 |
Goat anti-Mouse IgG (H+L) Cross-Adsorbed Secondary Antibody, Alexa Fluor 633 |
| secondary-0687 |
|
secondary |
|
AB_2535739 |
Donkey anti-Goat IgG (H+L) Cross-Adsorbed Secondary Antibody, Alexa Fluor 633 |
| secondary-0779 |
|
secondary |
|
AB_2534018 |
Donkey anti-Rabbit IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor 680 |
| secondary-0789 |
|
secondary |
|
AB_220030 |
Rat IgG (H&L) Antibody |