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Property	Value
Working Groups	RG Cramer
Subproject	None
Open Access	No
Publication Type	Journal Article
Peer Reviewed	Yes
PMID	33902108
DOI	10.1038/s41586-021-03555-7
Publication Year	2021
Title	Structure of the human Mediator–RNA polymerase II pre-initiation complex
Journal	Nature
ISSN	0028-0836
eISSN	1476-4687
URL	http://dx.doi.org/10.1038/s41586-021-03555-7
Pages	129-133
Issue	7861
Volume	594
Journal Abbreviation	Nature
Authors	Rengachari S, Schilbach S, Aibara S, Dienemann C, Cramer P
First Author	Rengachari S
Last Author	Cramer P

 External Resources

 55218https://www.addgene.org/55218 Addgene identifier (reused)

 55220https://www.addgene.org/55220 Addgene identifier (reused)

 EMD-12609https://www.ebi.ac.uk/pdbe/emdb/EMD-12609 EMBL-EBI EMDB identifier (EMD-12609)

 EMD-12610https://www.ebi.ac.uk/pdbe/emdb/EMD-12610 EMBL-EBI EMDB identifier (EMD-12610)

 2/100175https://publications.goettingen-research-online.de/handle/2/100175 GRO.publications identifier

 9606https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 NCBI taxonomy (human, Homo sapiens)

 0000-0001-9071-8515https://orcid.org/0000-0001-9071-8515 ORCID identifier (Sandra Schilbach)

 0000-0003-2221-482Xhttps://orcid.org/0000-0003-2221-482X ORCID identifier (Shintaro Aibara)

 0000-0002-2172-5110https://orcid.org/0000-0002-2172-5110 ORCID identifier (Christian Dienemann)

 0000-0001-5454-7755https://orcid.org/0000-0001-5454-7755 ORCID identifier (Patrick Cramer)

 7NVRhttps://www.rcsb.org/structure/7NVR RCSB PDB Identifier (7NVR)

 1/374https://mbexc.uni-goettingen.de/archive/1/374 Research Data Archive (supplemental material)

 03e76ya46https://ror.org/03e76ya46 ROR identifier (03e76ya46, Max Planck Institute for Biophysical Chemistry)

 05xy1nn52https://ror.org/05xy1nn52 ROR identifier (05xy1nn52, Multiscale Bioimaging)

 SCR_014222https://scicrunch.org/resolver/SCR_014222 SciCrunch identifier (RRID:SCR_014222, Coot)

 SCR_016501https://scicrunch.org/resolver/SCR_016501 SciCrunch identifier (RRID:SCR_016501, cryoSPARC)

 SCR_014226https://scicrunch.org/resolver/SCR_014226 SciCrunch identifier (RRID:SCR_014226, MolProbity)

 SCR_014224https://scicrunch.org/resolver/SCR_014224 SciCrunch identifier (RRID:SCR_014224, Phenix)

 SCR_000305https://scicrunch.org/resolver/SCR_000305 SciCrunch identifier (RRID:SCR_000305, PyMOL)

 SCR_016274https://scicrunch.org/resolver/SCR_016274 SciCrunch identifier (RRID:SCR_016274, RELION)

 SCR_017293https://scicrunch.org/resolver/SCR_017293 SciCrunch identifier (RRID:SCR_017293, SerialEM)

 SCR_004097https://scicrunch.org/resolver/SCR_004097 SciCrunch identifier (RRID:SCR_004097, UCSF Chimera)

 SCR_015872https://scicrunch.org/resolver/SCR_015872 SciCrunch identifier (RRID:SCR_015872, UCSF ChimeraX)

 SCR_018071https://scicrunch.org/resolver/SCR_018071 SciCrunch identifier (RRID:SCR_018071, Warp)

 static-c...SM.pdfhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41586-021-03555-7/MediaObjects/41586_2021_3555_MOESM1_ESM.pdf Supplemental material (figure)

 goeseek.gwdguser.de/studies/138https://goeseek.gwdguser.de/studies/138 Supplemental material (goeseek study)

 static-c...SM.pdfhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41586-021-03555-7/MediaObjects/41586_2021_3555_MOESM3_ESM.pdf Supplemental material (peer review)

 static-c...SM.pdfhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41586-021-03555-7/MediaObjects/41586_2021_3555_MOESM2_ESM.pdf Supplemental material (reporting summary)

 static-c...M.xlsxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41586-021-03555-7/MediaObjects/41586_2021_3555_MOESM5_ESM.xlsx Supplemental material (table)

 static-c...SM.mp4https://static-content.springer.com/esm/art%3A10.1038%2Fs41586-021-03555-7/MediaObjects/41586_2021_3555_MOESM4_ESM.mp4 Supplemental material (video)

 mbexc.de...mplex/https://mbexc.de/structure-of-human-mediator-rna-polymerase-ii-transcription-pre-initiation-complex/ Website entry (mbexc.de)

Linked Antibodies

PID	AG	Type	Antigen symbol	Antibody Registry ID	Name
primary-0576		primary	POLR2C	AB_11218388	RPB3 Antibody
primary-0777		primary	POLR2A	AB_2801296	Anti-RNA polymerase II subunit B1 (phospho-CTD Ser-5) Antibody
secondary-0670		secondary		AB_772206	Donkey Anti-Rabbit IgG, Whole Ab ECL Antibody
secondary-0778		secondary		AB_258429	Anti-Rat IgG (whole molecule)−Peroxidase antibody