| Property |
Value |
| Working Groups |
RG Cyganek, 
RG Wollnik, 
RG Zimmermann |
| Subproject |
None |
| Open Access |
Yes |
| Publication Type |
Journal Article |
| Peer Reviewed |
Yes |
| PMID |
41988707 |
| DOI |
10.1161/circulationaha.125.074155 |
| Publication Year |
2026 |
| Title |
Targeting Interleukin-8–Mediated Cellular Crosstalk Reverses Hypertrophic Cardiomyopathy and Cardiac Fibrosis in Noonan Syndrome |
| Journal |
Circulation |
| ISSN |
0009-7322 |
| eISSN |
1524-4539 |
| URL |
https://doi.org/10.1161/circulationaha.125.074155 |
| Journal Abbreviation |
Circulation |
| Authors |
Fell J, Pavez-Giani M, Koitka F, Kensah G, Santos GL, van der Vorst EP, Lenz C, Salinas G, Busley AV, Fedorenko A, Hindmarsh R, Wolf CM, Lutz S, Hasenfuss G, Zimmermann W, Wollnik B, Cyganek L |
| First Author |
Fell J |
| Last Author |
Cyganek L |
External Resources
90227https://www.addgene.org/90227 Addgene identifier (90227, reused)
12259https://www.addgene.org/12259 Addgene identifier (12259, reused)
12260https://www.addgene.org/12260 Addgene identifier (12260, reused)
file:///...ac.pdfhttp://file:///C:/Users/kulikova/Downloads/fell-et-al-2026-targeting-interleukin-8-mediated-cellular-crosstalk-reverses-hypertrophic-cardiomyopathy-and-cardiac.pdf Article fulltext
2/165140https://publications.goettingen-research-online.de/handle/2/165140 GRO.publications identifier
GSE271775https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE271775 NCBI GEO Dataset (GSE271775)
0000-0002-3330-9384https://orcid.org/0000-0002-3330-9384 ORCID identifier (Mario Pavez-Giani)
0009-0007-5226-9676https://orcid.org/0009-0007-5226-9676 ORCID identifier (Fabian Koitka)
0000-0003-0219-8279https://orcid.org/0000-0003-0219-8279 ORCID identifier (George Kensah)
0000-0001-7253-9855https://orcid.org/0000-0001-7253-9855 ORCID identifier (Gabriela Leão Santos)
0000-0001-5771-6278https://orcid.org/0000-0001-5771-6278 ORCID identifier (Emiel van der Vorst)
0000-0002-0946-8166https://orcid.org/0000-0002-0946-8166 ORCID identifier (Christof Lenz)
0000-0001-8269-2669https://orcid.org/0000-0001-8269-2669 ORCID identifier (Gabriela Salinas-Riester)
0000-0002-5036-0093https://orcid.org/0000-0002-5036-0093 ORCID identifier (Alexandra Viktoria Busley)
0009-0008-1090-2477https://orcid.org/0009-0008-1090-2477 ORCID identifier (Alisa Fedorenko)
0000-0003-4701-5843https://orcid.org/0000-0003-4701-5843 ORCID identifier (Cordula Wolf)
0000-0002-0554-8070https://orcid.org/0000-0002-0554-8070 ORCID identifier (Susanne Lutz)
0000-0002-5942-361Xhttps://orcid.org/0000-0002-5942-361X ORCID identifier (Gerd Hasenfuß)
0000-0003-1190-4040https://orcid.org/0000-0003-1190-4040 ORCID identifier (Wolfram-Hubertus Zimmermann)
0000-0003-2589-0364https://orcid.org/0000-0003-2589-0364 ORCID identifier (Bernd Wollnik)
0000-0001-9120-1382https://orcid.org/0000-0001-9120-1382 ORCID identifier (Lukas Cyganek)
PXD053691http://proteomecentral.proteomexchange.org/cgi/GetDataset?ID=PXD053691 Pride proteome dataset (PXD053691)
580https://sfb1002.med.uni-goettingen.de/production/literature/publications/580 Published Data Registry entry (CRC 1002)
1/794https://mbexc.uni-goettingen.de/archive/1/794 Research Data Archive (supplemental material)
04hbwba26https://ror.org/04hbwba26 ROR identifier (04hbwba26, Deutsches Herzzentrum München)
01s1h3j07https://ror.org/01s1h3j07 ROR identifier (01s1h3j07, Fraunhofer Institute for Translational Medicine and Pharmacology)
05591te55https://ror.org/05591te55 ROR identifier (05591te55, Ludwig Maximilian University of Munich)
05xy1nn52https://ror.org/05xy1nn52 ROR identifier (05xy1nn52, Multiscale Bioimaging)
02gm5zw39https://ror.org/02gm5zw39 ROR identifier (02gm5zw39, Universitätsklinikum Aachen)
021ft0n22https://ror.org/021ft0n22 ROR identifier (021ft0n22, University Medical Center Göttingen)
01y9bpm73https://ror.org/01y9bpm73 ROR identifier (01y9bpm73, University of Göttingen)
SCR_015058https://scicrunch.org/resolver/SCR_015058 SciCrunch identifier (RRID:SCR_015058, bcl2fastq)
SCR_019214https://scicrunch.org/resolver/SCR_019214 SciCrunch identifier (RRID:SCR_019214, biomaRt)
SCR_019037https://scicrunch.org/resolver/SCR_019037 SciCrunch identifier (RRID:SCR_019037, Bio-Rad: ChemiDoc MP Imaging System)
SCR_002080https://scicrunch.org/resolver/SCR_002080 SciCrunch identifier (RRID:SCR_002080, CASY Cell Counter and Analyser System Model TT)
SCR_021828https://scicrunch.org/resolver/SCR_021828 SciCrunch identifier (RRID:SCR_021828, Circa)
SCR_005748https://scicrunch.org/resolver/SCR_005748 SciCrunch identifier (RRID:SCR_005748, ClueGo)
SCR_003032https://scicrunch.org/resolver/SCR_003032 SciCrunch identifier (RRID:SCR_003032, Cytoscape)
SCR_015687https://scicrunch.org/resolver/SCR_015687 SciCrunch identifier (RRID:SCR_015687, DESeq2)
SCR_019840https://scicrunch.org/resolver/SCR_019840 SciCrunch identifier (RRID:SCR_019840, Dionex: Ultimate 3000 system)
SCR_014583https://scicrunch.org/resolver/SCR_014583 SciCrunch identifier (RRID:SCR_014583, FastQC)
SCR_010973https://scicrunch.org/resolver/SCR_010973 SciCrunch identifier (RRID:SCR_010973, GenomeStudio)
SCR_002798https://scicrunch.org/resolver/SCR_002798 SciCrunch identifier (RRID:SCR_002798, GraphPad Prism)
SCR_003070https://scicrunch.org/resolver/SCR_003070 SciCrunch identifier (RRID:SCR_003070, ImageJ)
SCR_020124https://scicrunch.org/resolver/SCR_020124 SciCrunch identifier (RRID:SCR_020124, Illumina: BeadArray Reader)
SCR_016386https://scicrunch.org/resolver/SCR_016386 SciCrunch identifier (RRID:SCR_016386, Illumina HiSeq 3000/HiSeq 4000 Sequencing System)
SCR_003420https://scicrunch.org/resolver/SCR_003420 SciCrunch identifier (RRID:SCR_003420, nSolver Analysis Software)
SCR_015753https://scicrunch.org/resolver/SCR_015753 SciCrunch identifier (RRID:SCR_015753, Perseus)
SCR_027715https://www.addgene.org/SCR_027715 SciCrunch identifier (RRID:SCR_027715, StarDist)
SCR_027000https://scicrunch.org/resolver/SCR_027000 SciCrunch identifier (RRID:SCR_027000, Thermo Fisher: Orbitrap Exploris 480 Mass Spectrometer)
SCR_023147https://scicrunch.org/resolver/SCR_023147 SciCrunch identifier (RRID:SCR_023147, Thermo Fisher: Sartorius: IncuCyte S3 Live Cell Analysis System)
SCR_018623https://scicrunch.org/resolver/SCR_018623 SciCrunch identifier (RRID:SCR_018623, Qiagen: Tissue Lyser II)
SCR_024706https://scicrunch.org/resolver/SCR_024706 SciCrunch identifier (RRID:SCR_024706, Zeiss: Axio Imager M2)
SCR_027509https://scicrunch.org/resolver/SCR_027509 SciCrunch identifier (RRID:SCR_027509, Zeiss: SteREO Discovery.V12)
ahajourn...01.pdfhttps://www.ahajournals.org/doi/suppl/10.1161/CIRCULATIONAHA.125.074155/suppl_file/circ-2025-074155-s01.pdf Supplemental material
ahajourn...02.pdfhttps://www.ahajournals.org/doi/suppl/10.1161/CIRCULATIONAHA.125.074155/suppl_file/circ-2025-074155-s02.pdf Supplemental material
mbexc.de...drome/https://mbexc.de/targeting-interleukin-8-mediated-cellular-crosstalk-reverses-hypertrophic-cardiomyopathy-and-cardiac-fibrosis-in-noonan-syndrome/ Website entry (mbexc.de)
Linked Antibodies
| PID |
AG |
Type |
Antigen symbol |
Antibody Registry ID |
Name |
| primary-0097 |
|
primary |
MAPK |
AB_2139682 |
Phospho-p38 MAPK (Thr180/Tyr182) (D3F9) XP Rabbit mAb antibody |
| primary-0098 |
|
primary |
p38 MAPK |
AB_330713 |
p38 MAPK Antibody |
| primary-0099 |
|
primary |
MAPK3/MAPK1 |
AB_331646 |
Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) Antibody |
| primary-0100 |
|
primary |
MAPK3/MAPK1 |
AB_330744 |
p44/42 MAPK (Erk1/2) Antibody |
| primary-0102 |
|
primary |
ACTN2 |
AB_476766 |
Anti-α-Actinin (Sarcomeric) antibody |
| primary-0205 |
 |
primary |
RPS6 |
AB_331355 |
S6 Ribosomal Protein (5G10) Rabbit mAb |
| primary-0472 |
 |
primary |
TRA-1-60 |
AB_778563 |
Anti-TRA-1-60 (R) antibody [TRA-1-60] |
| primary-0473 |
|
primary |
TRA-1-60 |
AB_1645379 |
Alexa Fluor® 488 Mouse anti-Human TRA-1-60 Antigen |
| primary-0815 |
 |
primary |
VCL |
AB_477629 |
Monoclonal Anti-Vinculin antibody |
| primary-1155 |
|
primary |
Oct3 |
AB_2784442 |
Oct3/4 Antibody, anti-human/mouse, REAfinity |
| primary-1157 |
|
primary |
|
AB_2536677 |
Nanog Monoclonal Antibody (23D2-3C6) |
| primary-1160 |
|
primary |
MRAS |
AB_10950895 |
MRAS Polyclonal antibody |
| primary-1163 |
|
primary |
RAS10 |
AB_2121151 |
Anti-Ras-Antikörper, Klon RAS10 |
| primary-1183 |
|
primary |
TNNI3 |
AB_11000742 |
Cardiac Troponin T Monoclonal Antibody (13-11) |
| primary-1641 |
|
primary |
LZTR1 |
AB_3076250 |
Anti-LZTR1 antibody [EPR25253-51] |
| primary-1643 |
|
primary |
RIT1 |
AB_882379 |
Anti-RIT1/RIT antibody |
| primary-2009 |
|
primary |
EIF4EBP1 |
AB_2097841 |
4E-BP1 monoclonal rabbit |
| primary-2010 |
|
primary |
4E-BP1 |
AB_560835 |
Phospho-4E-BP1 monoclonal rabbit |
| primary-2011 |
|
primary |
|
AB_476766 |
α-actinin monoclonal mouse |
| primary-2012 |
|
primary |
|
AB_329827 |
AKT polyclonal rabbit |
| primary-2013 |
|
primary |
|
AB_329825 |
Phospho-AKT polyclonal rabbit |
| primary-2014 |
|
primary |
CDH5 |
AB_2077957 |
VE-cadherin (F-8) |
| primary-2018 |
|
primary |
MAPK7 |
AB_330491 |
ERK5 polyclonal rabbit |
| primary-2019 |
|
primary |
COL1A1 |
AB_2920541 |
COL1A1 monoclonal mouse |
| primary-2020 |
|
primary |
|
AB_2140424 |
Phospho-ERK5 polyclonal rabbit |
| primary-2021 |
|
primary |
SAPK/JNK |
AB_2250373 |
JNK polyclonal rabbit |
| primary-2022 |
|
primary |
SAPK/JNK |
AB_331659 |
Phospho-JNK polyclonal rabbit |
| primary-2023 |
|
primary |
MKI67 |
AB_2687446 |
Ki-67 monoclonal rabbit |
| primary-2024 |
|
primary |
MEK1/2 |
AB_823567 |
MEK1/2 polyclonal rabbit |
| primary-2025 |
|
primary |
MEK1/2 |
AB_331648 |
Phospho-MEK1/2 polyclonal rabbit |
| primary-2026 |
|
primary |
CD31 |
AB_779679 |
PECAM1 monoclonal mouse |
| primary-2027 |
|
primary |
RPS6 |
AB_916156 |
Phospho-S6 monoclonal rabbit |
| primary-2028 |
|
primary |
RPS6KB1 |
AB_390722 |
S6K monoclonal rabbit |
| primary-2029 |
|
primary |
RPS6KB1 |
AB_2269803 |
Phospho-S6K monoclonal rabbit |
| secondary-0032 |
 |
secondary |
|
AB_143165 |
Goat anti-Rabbit IgG (H+L) Cross-Adsorbed Secondary Antibody, Alexa Fluor 488 |
| secondary-0491 |
 |
secondary |
|
AB_2536180 |
Donkey anti-Mouse IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor 555 |
| secondary-1161 |
|
secondary |
|
AB_2722659 |
Kaninchen-IgG, HRP-verknüpfter Vollantikörper |
| secondary-1162 |
|
secondary |
|
AB_772210 |
Maus-IgG, HRP-verknüpfter Vollantikörper |