| Property |
Value |
| Working Groups |
RG Fernandez-Busnadiego, 
RG Outeiro |
| Subproject |
None |
| Open Access |
Yes |
| Publication Type |
Preprint |
| Peer Reviewed |
No |
| PMID |
39990587 |
| DOI |
10.1101/2025.02.07.25321793 |
| Publication Year |
2025 |
| Title |
A novel alpha-synuclein K58N missense variant in a patient with Parkinson's disease |
| Journal |
medRxiv |
| eISSN |
3067-2007 |
| URL |
https://doi.org/10.1101/2025.02.07.25321793 |
| Journal Abbreviation |
medRxiv |
| Extra |
Not yet finally published in a peer-reviewed journal |
| Authors |
Al-Azzani M, Weber S, Ramalingam N, Ramón M, Shvachiy L, Mestre G, Zech M, Sicking K, Ibáñez de Opakua A, Jayanthi V, Amaral L, Agarwal A, Chandran A, Chaves SR, Winkelmann J, Trenkwalder C, Schwager M, Pauli S, Dettmer U, Fernández CO, Lautenschläger J, Zweckstetter M, Busnadiego RF, Mollenhauer B, Outeiro TF |
| First Author |
Al-Azzani M |
| Last Author |
Outeiro TF |
External Resources
12259https://www.addgene.org/12259 Addgene identifier (12259, reused)
12260https://www.addgene.org/12260 Addgene identifier (12260, reused)
96808https://www.addgene.org/96808 Addgene identifier (96808, reused)
178032https://www.addgene.org/178032 Addgene identifier (178032, reused)
medrxiv....ll.pdfhttps://www.medrxiv.org/content/10.1101/2025.02.07.25321793v2.full.pdf Article fulltext
2/149981https://publications.goettingen-research-online.de/handle/2/149981 GRO.publications identifier
9606https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 NCBI taxonomy (human, Homo sapiens)
1247190https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=1247190 NCBI taxonomy (yeast, Saccharomyces cerevisiae BY4741)
EMD-52165https://www.ebi.ac.uk/pdbe/emdb/EMD-52165 EMBL-EBI EMDB identifier (EMD-52165)
EMD-52458https://www.ebi.ac.uk/pdbe/emdb/EMD-52458 EMBL-EBI EMDB identifier (EMD-52458)
EMPIAR-12518https://www.ebi.ac.uk/empiar/EMPIAR-12518 EMBL-EBI EMPIAR identifier (EMPIAR-12518)
0000-0003-2864-0854https://orcid.org/0000-0003-2864-0854 ORCID identifier (Mohammed Al-Azzani)
0000-0002-6004-9872https://orcid.org/0000-0002-6004-9872 ORCID identifier (Susana R. Chaves)
0000-0001-6407-1199https://orcid.org/0000-0001-6407-1199 ORCID identifier (Claudia Trenkwalder)
0000-0001-7788-7074https://orcid.org/0000-0001-7788-7074 ORCID identifier (Janin Lautenschläger)
0000-0002-2536-6581https://orcid.org/0000-0002-2536-6581 ORCID identifier (Markus Zweckstetter)
0000-0002-8366-7622https://orcid.org/0000-0002-8366-7622 ORCID identifier (Ruben Fernandez-Busnadiego)
0000-0001-8437-3645https://orcid.org/0000-0001-8437-3645 ORCID identifier (Brit Mollenhauer)
0000-0003-1679-1727https://orcid.org/0000-0003-1679-1727 ORCID identifier (Tiago Fleming Outeiro)
358https://sfb1286.uni-goettingen.de/literature/publications/358 Published Data Registry entry (CRC 1286)
9HXAhttps://www.rcsb.org/structure/9HXA RCSB PDB Identifier (DOI:10.2210/pdb9HXA/pdb)
1/771https://mbexc.uni-goettingen.de/archive/1/771 Research Data Archive (supplemental material)
04b6nzv94https://ror.org/04b6nzv94 ROR identifier (04b6nzv94, Brigham and Women's Hospital)
043j0f473https://ror.org/043j0f473 ROR identifier (043j0f473, German Center for Neurodegenerative Diseases)
03vek6s52https://ror.org/03vek6s52 ROR identifier (03vek6s52, Harvard University)
00cfam450https://ror.org/00cfam450 ROR identifier (00cfam450, Helmholtz Zentrum München)
03av75f26https://ror.org/03av75f26 ROR identifier (03av75f26, Max Planck Institute for Multidisciplinary Sciences)
05xy1nn52https://ror.org/05xy1nn52 ROR identifier (05xy1nn52, Multiscale Bioimaging)
021ft0n22https://ror.org/021ft0n22 ROR identifier (021ft0n22, University Medical Center Göttingen)
013meh722https://ror.org/013meh722 ROR identifier (013meh722, University of Cambridge)
037wpkx04https://ror.org/037wpkx04 ROR identifier (037wpkx04, University of Minho)
CVCL_0030https://scicrunch.org/resolver/CVCL_0030 SciCrunch identifier (RRID:CVCL_0030, HeLa)
SCR_018392https://scicrunch.org/resolver/SCR_018392 SciCrunch identifier (RRID:SCR_018392, crYOLO)
SCR_002798https://scicrunch.org/resolver/SCR_002798 SciCrunch identifier (RRID:SCR_002798, GraphPad Prism)
SCR_014565https://scicrunch.org/resolver/SCR_014565 SciCrunch identifier (RRID:SCR_014565, GROMACS)
SCR_016387https://scicrunch.org/resolver/SCR_016387 SciCrunch identifier (RRID:SCR_016387, Illumina NovaSeq 6000 Sequencing System)
SCR_016137https://scicrunch.org/resolver/SCR_016137 SciCrunch identifier (RRID:SCR_016137, Microsoft Excel)
SCR_016499https://scicrunch.org/resolver/SCR_016499 SciCrunch identifier (RRID:SCR_016499, MotionCor2)
SCR_000305https://scicrunch.org/resolver/SCR_000305 SciCrunch identifier (RRID:SCR_000305, PyMOL)
SCR_016274https://scicrunch.org/resolver/SCR_016274 SciCrunch identifier (RRID:SCR_016274, RELION)
SCR_014228https://scicrunch.org/resolver/SCR_014228 SciCrunch identifier (RRID:SCR_014228, Sparky)
SCR_014227https://scicrunch.org/resolver/SCR_014227 SciCrunch identifier (RRID:SCR_014227, TopSpin)
SCR_021351https://scicrunch.org/resolver/SCR_021351 SciCrunch identifier (RRID:SCR_021351, Zeiss Axio Observer)
SCR_020922https://scicrunch.org/resolver/SCR_020922 SciCrunch identifier (RRID:SCR_020922, Zeiss LSM 780 Confocal Laser Scanning Microscope)
SCR_022263https://scicrunch.org/resolver/SCR_022263 SciCrunch identifier (RRID:SCR_022263, Zeiss LSM 900 with Airyscan 2)
SCR_013672https://scicrunch.org/resolver/SCR_013672 SciCrunch identifier (RRID:SCR_013672, ZEN Digital Imaging for Light Microscopy)
medrxiv....d=truehttps://www.medrxiv.org/content/medrxiv/early/2025/02/14/2025.02.07.25321793/DC1/embed/media-1.pdf?download=true Supplemental material
protocol...lpk/v1https://www.protocols.io/view/single-particle-analysis-of-synuclein-fibrils-81wgbxozylpk/v1 Supplemental material (protocol)
10.1101/2025.02.07.25321793http://10.1101/2025.02.07.25321793 Website entry (mbexc.de)
10.5281/zenodo.14730688https://doi.org/10.5281/zenodo.14730688 Zenodo identifier (10.5281/zenodo.14730688)