| Property |
Value |
| Working Groups |
RG Cyganek, 
RG Hasenfuß, 
RG Wollnik, 
RG Zimmermann |
| Subproject |
None |
| Open Access |
Yes |
| Publication Type |
Journal Article |
| Peer Reviewed |
Yes |
| PMID |
39003740 |
| DOI |
10.1016/j.celrep.2024.114448 |
| Publication Year |
2024 |
| Title |
Mutation-induced LZTR1 polymerization provokes cardiac pathology in recessive Noonan syndrome |
| Journal |
Cell Reports |
| ISSN |
2211-1247 |
| eISSN |
2211-1247 |
| URL |
http://dx.doi.org/10.1016/j.celrep.2024.114448 |
| Pages |
114448 |
| Issue |
7 |
| Volume |
43 |
| Journal Abbreviation |
Cell Rep |
| Authors |
Busley AV, Gutiérrez-Gutiérrez O, Hammer E, Koitka F, Mirzaiebadizi A, Steinegger M, Pape C, Böhmer L, Schroeder H, Kleinsorge M, Engler M, Cirstea IC, Gremer L, Willbold D, Altmüller J, Marbach F, Hasenfuss G, Zimmermann WH, Reza Ahmadian M, Wollnik B, Cyganek L |
| First Author |
Busley AV |
| Last Author |
Cyganek L |
External Resources
12259https://www.addgene.org/12259 Addgene identifier (12259, reused)
12260https://www.addgene.org/12260 Addgene identifier (12260, reused)
13512https://www.addgene.org/13512 Addgene identifier (13512, reused)
90227https://www.addgene.org/90227 Addgene identifier (90227, reused)
cell.com...0777-0https://www.cell.com/cell-reports/pdfExtended/S2211-1247(24)00777-0 Article fulltext
sfb1002....ine=16https://sfb1002.med.uni-goettingen.de/production/cellmodel/cell-line/view?tab=internal&line=16 Cell Model Catalogue (UMGi014-C)
sfb1002....ine=29https://sfb1002.med.uni-goettingen.de/production/cellmodel/cell-line/view?tab=internal&line=29 Cell Model Catalogue (UMGi130-A)
sfb1002....ine=50https://sfb1002.med.uni-goettingen.de/production/cellmodel/cell-line/view?tab=internal&line=50 Cell Model Catalogue (UMGi137-A)
sfb1002....ne=450https://sfb1002.med.uni-goettingen.de/production/cellmodel/cell-line/view?tab=gen_mod&line=450 Cell Model Catalogue (UMGi137-A-1)
9606https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 NCBI taxonomy (human, Homo sapiens)
0000-0002-5036-0093https://orcid.org/0000-0002-5036-0093 ORCID identifier (Alexandra Viktoria Busley)
0000-0002-1507-0402https://orcid.org/0000-0002-1507-0402 ORCID identifier (Elke Hammer)
0009-0007-5226-9676https://orcid.org/0009-0007-5226-9676 ORCID identifier (Fabian Koitka)
0000-0002-3340-586Xhttps://orcid.org/0000-0002-3340-586X ORCID identifier (Amin Mirzaiebadizi)
0000-0001-6562-7187https://orcid.org/0000-0001-6562-7187 ORCID identifier (Constantin Pape)
0000-0001-7184-5770https://orcid.org/0000-0001-7184-5770 ORCID identifier (Mandy Kleinsorge)
0000-0002-5018-4712https://orcid.org/0000-0002-5018-4712 ORCID identifier (Melanie Engler)
0000-0003-3204-1598https://orcid.org/0000-0003-3204-1598 ORCID identifier (Ion Cristian Cirstea)
0000-0001-7065-5027https://orcid.org/0000-0001-7065-5027 ORCID identifier (Lothar Gremer)
0000-0002-0065-7366https://orcid.org/0000-0002-0065-7366 ORCID identifier (Dieter Willbold)
0000-0003-4372-1521https://orcid.org/0000-0003-4372-1521 ORCID identifier (Janine Altmüller)
0000-0003-3953-6235https://orcid.org/0000-0003-3953-6235 ORCID identifier (Felix Marbach)
0000-0002-5942-361Xhttps://orcid.org/0000-0002-5942-361X ORCID identifier (Gerd Hasenfuß)
0000-0003-1190-4040https://orcid.org/0000-0003-1190-4040 ORCID identifier (Wolfram Hubertus Zimmermann)
0000-0002-2034-8894https://orcid.org/0000-0002-2034-8894 ORCID identifier (Mohammad Reza Ahmadian)
0000-0003-2589-0364https://orcid.org/0000-0003-2589-0364 ORCID identifier (Bernd Wollnik)
0000-0001-9120-1382https://orcid.org/0000-0001-9120-1382 ORCID identifier (Lukas Cyganek)
PXD038417http://proteomecentral.proteomexchange.org/cgi/GetDataset?ID=PXD038417 Pride proteome dataset (PXD038417)
PXD038425http://proteomecentral.proteomexchange.org/cgi/GetDataset?ID=PXD038425 Pride proteome dataset (PXD038425)
535https://sfb1002.med.uni-goettingen.de/production/literature/publications/535 Published Data Registry entry (CRC 1002)
646https://prod.mbexc.uni-goettingen.de/literature/publications/646 Published Data Registry entry (MBExC, preprint)
1/482https://mbexc.uni-goettingen.de/archive/1/482 Research Data Archive (supplemental material)
02nv7yv05https://ror.org/02nv7yv05 ROR identifier (02nv7yv05, Forschungszentrum Jülich)
01s1h3j07https://ror.org/01s1h3j07 ROR identifier (01s1h3j07, Fraunhofer Institute for Translational Medicine and Pharmacology)
031t5w623https://ror.org/031t5w623 ROR identifier (031t5w623, German Centre for Cardiovascular Research)
038t36y30https://ror.org/038t36y30 ROR identifier (038t36y30, Heidelberg University)
024z2rq82https://ror.org/024z2rq82 ROR identifier (024z2rq82, Heinrich Heine University Düsseldorf)
04p5ggc03https://ror.org/04p5ggc03 ROR identifier (04p5ggc03, Max Delbrück Center for Molecular Medicine)
03av75f26https://ror.org/03av75f26 ROR identifier (03av75f26, Max Planck Institute for Multidisciplinary Sciences)
05xy1nn52https://ror.org/05xy1nn52 ROR identifier (05xy1nn52, Multiscale Bioimaging)
04h9pn542https://ror.org/04h9pn542 ROR identifier (04h9pn542, Seoul National University)
032000t02https://ror.org/032000t02 ROR identifier (032000t02, Universität Ulm)
05mxhda18https://ror.org/05mxhda18 ROR identifier (05mxhda18, University Hospital Cologne)
021ft0n22https://ror.org/021ft0n22 ROR identifier (021ft0n22, University Medical Center Göttingen)
01y9bpm73https://ror.org/01y9bpm73 ROR identifier (01y9bpm73, University of Göttingen)
00r1edq15https://ror.org/00r1edq15 ROR identifier (00r1edq15, University of Greifswald)
CVCL_D615https://scicrunch.org/resolver/CVCL_D615 SciCrunch identifier (RRID:CVCL_D615, Expi293F)
CVCL_0063https://scicrunch.org/resolver/CVCL_0063 SciCrunch identifier (RRID:CVCL_0063, HEK293T)
CVCL_3285https://scicrunch.org/resolver/CVCL_3285 SciCrunch identifier (RRID:CVCL_3285, HFF-1)
SCR_023662https://scicrunch.org/resolver/SCR_023662 SciCrunch identifier (RRID:SCR_023662, AlphaFold Protein Structure Database)
SCR_019690https://scicrunch.org/resolver/SCR_019690 SciCrunch identifier (RRID:SCR_019690, Bio-Rad Chemidoc XRS Gel Imaging System)
SCR_007358https://scicrunch.org/resolver/SCR_007358 SciCrunch identifier (RRID:SCR_007358, CellProfiler)
SCR_015935https://scicrunch.org/resolver/SCR_015935 SciCrunch identifier (RRID:SCR_015935, CRISPOR)
SCR_010973https://scicrunch.org/resolver/SCR_010973 SciCrunch identifier (RRID:SCR_010973, GenomeStudio)
SCR_002798https://scicrunch.org/resolver/SCR_002798 SciCrunch identifier (RRID:SCR_002798, GraphPad Prism)
SCR_003032https://scicrunch.org/resolver/SCR_003032 SciCrunch identifier (RRID:SCR_003032, Cytoscape)
SCR_016386https://scicrunch.org/resolver/SCR_016386 SciCrunch identifier (RRID:SCR_016386, Illumina HiSeq 3000/HiSeq 4000 System)
SCR_014210https://scicrunch.org/resolver/SCR_014210 SciCrunch identifier (RRID:SCR_014210, Image Lab Software)
SCR_003070https://scicrunch.org/resolver/SCR_003070 SciCrunch identifier (RRID:SCR_003070, ImageJ)
SCR_017551https://scicrunch.org/resolver/SCR_017551 SciCrunch identifier (RRID:SCR_017551, LabChart Reader)
SCR_001622https://scicrunch.org/resolver/SCR_001622 SciCrunch identifier (RRID:SCR_001622, MATLAB)
SCR_010777https://scicrunch.org/resolver/SCR_010777 SciCrunch identifier (RRID:SCR_010777, MutationTaster)
SCR_013189https://scicrunch.org/resolver/SCR_013189 SciCrunch identifier (RRID:SCR_013189, PolyPhen)
SCR_003485https://scicrunch.org/resolver/SCR_003485 SciCrunch identifier (RRID:SCR_003485, Reactome)
SCR_012813https://scicrunch.org/resolver/SCR_012813 SciCrunch identifier (RRID:SCR_012813, SIFT)
SCR_020563https://scicrunch.org/resolver/SCR_020563 SciCrunch identifier (RRID:SCR_020563, Thermo Scientific Dionex Ultimate 3000 system)
SCR_002380https://scicrunch.org/resolver/SCR_002380 SciCrunch identifier (RRID:SCR_002380, UniProt)
SCR_018876https://scicrunch.org/resolver/SCR_018876 SciCrunch identifier (RRID:SCR_018876, Zeiss: Axio Imager 2)
cell.com...c1.pdfhttps://www.cell.com/cms/10.1016/j.celrep.2024.114448/attachment/ce7638e3-bdbb-4525-9afb-3c0d322f9fe5/mmc1.pdf Supplemental material
colab.re....ipynbhttps://colab.research.google.com/github/sokrypton/ColabFold/blob/main/AlphaFold2.ipynb Supplemental material (code, reused)
mbexc.de...drome/https://mbexc.de/mutation-induced-lztr1-polymerization-provokes-cardiac-pathology-in-recessive-noonan-syndrome/ Website entry (mbexc.de)
Linked Antibodies
| PID |
AG |
Type |
Antigen symbol |
Antibody Registry ID |
Name |
| primary-0102 |
|
primary |
ACTN2 |
AB_476766 |
Anti-α-Actinin (Sarcomeric) antibody |
| primary-0313 |
 |
primary |
FLAG |
AB_262044 |
Monoclonal ANTI-FLAG® M2 antibody |
| primary-0472 |
|
primary |
TRA-1-60 |
AB_778563 |
Anti-TRA-1-60 (R) antibody [TRA-1-60] |
| primary-0473 |
|
primary |
TRA-1-60 |
AB_1645379 |
Alexa Fluor® 488 Mouse anti-Human TRA-1-60 Antigen |
| primary-0815 |
 |
primary |
VCL |
AB_477629 |
Monoclonal Anti-Vinculin antibody |
| primary-1155 |
|
primary |
Oct3 |
AB_2784442 |
Oct3/4 Antibody, anti-human/mouse, REAfinity |
| primary-1157 |
|
primary |
|
AB_2536677 |
Nanog Monoclonal Antibody (23D2-3C6) |
| primary-1159 |
|
primary |
MYL2 |
AB_2147453 |
Myosin Light Chain 2/MLC-2V Polyclonal antibody |
| primary-1160 |
|
primary |
MRAS |
AB_10950895 |
MRAS Polyclonal antibody |
| primary-1163 |
|
primary |
RAS10 |
AB_2121151 |
Anti-Ras-Antikörper, Klon RAS10 |
| primary-1306 |
 |
primary |
|
AB_1549585 |
HA-Tag (C29F4) Rabbit mAb |
| primary-1640 |
|
primary |
|
AB_2810125 |
6x-His Tag Recombinant Rabbit Monoclonal Antibody (RM146) |
| primary-1641 |
|
primary |
LZTR1 |
AB_3076250 |
Anti-LZTR1 antibody [EPR25253-51] |
| primary-1642 |
|
primary |
|
AB_331783 |
Myc-Tag (9B11) Mouse mAb |
| primary-1643 |
|
primary |
RIT1 |
AB_882379 |
Anti-RIT1/RIT antibody |
| secondary-0032 |
 |
secondary |
|
AB_143165 |
Goat anti-Rabbit IgG (H+L) Cross-Adsorbed Secondary Antibody, Alexa Fluor 488 |
| secondary-0491 |
 |
secondary |
|
AB_2536180 |
Donkey anti-Mouse IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor 555 |
| secondary-1161 |
|
secondary |
|
AB_2722659 |
Kaninchen-IgG, HRP-verknüpfter Vollantikörper |
| secondary-1162 |
|
secondary |
|
AB_772210 |
Maus-IgG, HRP-verknüpfter Vollantikörper |