| Property |
Value |
| Working Groups |
RG Fernandez-Busnadiego, 
RG Outeiro |
| Subproject |
None |
| Open Access |
Yes |
| Publication Type |
Journal Article |
| Peer Reviewed |
Yes |
| PMID |
41013605 |
| DOI |
10.1186/s13024-025-00889-y |
| Publication Year |
2025 |
| Title |
A novel alpha-synuclein G14R missense variant is associated with atypical neuropathological features |
| Journal |
Molecular Neurodegeneration |
| eISSN |
1750-1326 |
| URL |
https://doi.org/10.1186/s13024-025-00889-y |
| Issue |
1 |
| Volume |
20 |
| Journal Abbreviation |
Mol Neurodegeneration |
| Authors |
Brücke C, Al-Azzani M, Ramalingam N, Ramón M, Sousa RL, Buratti F, Zech M, Sicking K, Amaral L, Gelpi E, Chandran A, Agarwal A, Chaves SR, Fernández CO, Dettmer U, Lautenschläger J, Zweckstetter M, Fernández-Busnadiego R, Zimprich A, Outeiro TF |
| First Author |
Brücke C |
| Last Author |
Outeiro TF |
External Resources
12259https://www.addgene.org/12259 Addgene identifier (12259, reused)
12260https://www.addgene.org/12260 Addgene identifier (12260, reused)
96808https://www.addgene.org/96808 Addgene identifier (96808, reused)
link.spr...-y.pdfhttps://link.springer.com/content/pdf/10.1186/s13024-025-00889-y.pdf Article fulltext
EMD‐52165https://www.ebi.ac.uk/pdbe/emdb/EMD‐52165 EMBL-EBI EMDB identifier (EMD‐52165)
EMD‐52166https://www.ebi.ac.uk/pdbe/emdb/EMD‐52166 EMBL-EBI EMDB identifier (EMD‐52166)
EMPIAR‐12518https://www.ebi.ac.uk/empiar/EMPIAR‐12518 EMBL-EBI EMPIAR identifier (EMPIAR‐12518)
2/151509http://resolver.sub.uni-goettingen.de/purl?2/151509 GRO.publications identifier
NM_000345.4https://www.ncbi.nlm.nih.gov/nuccore/NM_000345.4 NCBI nucleotide (NM_000345.4, reused)
9606https://www.ncbi.nlm.nih.gov/nuccore/9606 NCBI taxonomy (human, Homo sapiens)
1247190https://www.ncbi.nlm.nih.gov/nuccore/1247190 NCBI taxonomy (yeast, Saccharomyces cerevisiae BY4741)
0000-0003-4640-2577https://orcid.org/0000-0003-4640-2577 ORCID identifier (Christof Brücke)
0000-0003-2864-0854https://orcid.org/0000-0003-2864-0854 RCID identifier (Mohammed Al-Azzani)
0000-0002-9459-3593https://orcid.org/0000-0002-9459-3593 ORCID identifier (Nagendran Ramalingam)
0000-0001-7019-0186https://orcid.org/0000-0001-7019-0186 ORCID identifier (Rita L. Sousa)
0009-0006-1755-1388https://orcid.org/0009-0006-1755-1388 ORCID identifier (Fiamma Buratti)
0000-0001-8828-835Xhttps://orcid.org/0000-0001-8828-835X ORCID identifier (Kevin Sicking)
0000-0003-2843-628Xhttps://orcid.org/0000-0003-2843-628X ORCID identifier (Leslie Amaral)
0000-0003-2948-4187https://orcid.org/0000-0003-2948-4187 ORCID identifier (Ellen Gelpi)
0009-0000-5229-4846https://orcid.org/0009-0000-5229-4846 ORCID identifier (Aishwarya Agarwal)
0000-0002-6004-9872https://orcid.org/0000-0002-6004-9872 ORCID identifier (Susana Chaves)
0000-0001-6676-0107https://orcid.org/0000-0001-6676-0107 ORCID identifier (Ulf Dettmer)
0000-0001-7788-7074https://orcid.org/0000-0001-7788-7074 ORCID identifier (Janin Lautenschläger)
0000-0002-2536-6581https://orcid.org/0000-0002-2536-6581 ORCID identifier (Markus Zweckstetter)
0000-0002-8366-7622https://orcid.org/0000-0002-8366-7622 ORCID identifier (Rubén Fernández-Busnadiego)
0000-0002-1668-5177https://orcid.org/0000-0002-1668-5177 ORCID identifier (Alexander Zimprich)
0000-0003-1679-1727https://orcid.org/0000-0003-1679-1727 ORCID identifier (Tiago Fleming Outeiro)
459https://sfb1286.uni-goettingen.de/literature/publications/459 Published Data Registry entry (CRC 1286)
1079https://prod.mbexc.uni-goettingen.de/literature/publications/1079 Published Data Registry entry (MBExC, preprint)
9HGShttps://www.rcsb.org/structure/9HGS RCSB PDB Identifier (DOI:10.2210/pdb9HGS/pdb)
9HGRhttps://www.rcsb.org/structure/9HGR RCSB PDB Identifier (DOI:10.2210/pdb9HGR/pdb)
6RT0https://www.rcsb.org/structure/6RT0 RCSB PDB Identifier (DOI:10.2210/pdb6RT0/pdb, reused)
8BQWhttps://www.rcsb.org/structure/8BQW RCSB PDB Identifier (DOI:10.2210/pdb8BQW/pdb, reused)
1/748https://mbexc.uni-goettingen.de/archive/1/748 Research Data Archive (supplemental material)
03zj4c476https://ror.org/03zj4c476 ROR identifier (03zj4c476, Aligning Science Across Parkinson's)
04b6nzv94https://ror.org/04b6nzv94 ROR identifier (04b6nzv94, Brigham and Women's Hospital)
043j0f473https://ror.org/043j0f473 ROR identifier (043j0f473, German Center for Neurodegenerative Diseases)
03vek6s52https://ror.org/03vek6s52 ROR identifier (03vek6s52, Harvard University)
00cfam450https://ror.org/00cfam450 ROR identifier (00cfam450, Helmholtz Zentrum München)
05n3x4p02https://ror.org/05n3x4p02 ROR identifier (05n3x4p02, Medical University of Vienna)
03av75f26https://ror.org/03av75f26 ROR identifier (03av75f26, Max Planck Institute for Multidisciplinary Sciences)
05xy1nn52https://ror.org/05xy1nn52 ROR identifier (05xy1nn52, Multiscale Bioimaging)
02tphfq59https://ror.org/02tphfq59 ROR identifier (02tphfq59, National University of Rosario)
01kj2bm70https://ror.org/01kj2bm70 ROR identifier (01kj2bm70, Newcastle University)
02kkvpp62https://ror.org/02kkvpp62 ROR identifier (02kkvpp62, Technical University of Munich)
021ft0n22https://ror.org/021ft0n22 ROR identifier (021ft0n22, University Medical Center Göttingen)
013meh722https://ror.org/013meh722 ROR identifier (013meh722, University of Cambridge)
01y9bpm73https://ror.org/01y9bpm73 ROR identifier (01y9bpm73, University of Göttingen)
037wpkx04https://ror.org/037wpkx04 ROR identifier (037wpkx04, University of Minho)
03prydq77https://ror.org/03prydq77 ROR identifier (03prydq77, University of Vienna)
CVCL_0063https://scicrunch.org/resolver/CVCL_0063 SciCrunch identifier (RRID:CVCL_0063, HEK293T)
CVCL_0030https://scicrunch.org/resolver/CVCL_0030 SciCrunch identifier (RRID:CVCL_0030, HeLa)
SCR_026330https://scicrunch.org/resolver/SCR_026330 SciCrunch identifier (RRID:SCR_026330, BMG Labtech: CLARIOstar Plus)
SCR_028510https://scicrunch.org/resolver/SCR_028510 SciCrunch identifier (RRID:SCR_028510, Bruker: Avance III HD Ascend 700 MHz NMR Spectrometer)
SCR_014222https://scicrunch.org/resolver/SCR_014222 SciCrunch identifier (RRID:SCR_014222, Coot)
SCR_018392https://scicrunch.org/resolver/SCR_018392 SciCrunch identifier (RRID:SCR_018392, crYOLO)
SCR_016732https://scicrunch.org/resolver/SCR_016732 SciCrunch identifier (RRID:SCR_016732, CTFFIND)
SCR_002285https://scicrunch.org/resolver/SCR_002285 SciCrunch identifier (RRID:SCR_002285, Fiji)
SCR_002798https://scicrunch.org/resolver/SCR_002798 SciCrunch identifier (RRID:SCR_002798, GraphPad Prism)
SCR_016387https://scicrunch.org/resolver/SCR_016387 SciCrunch identifier (RRID:SCR_016387, Illumina NovaSeq 6000 Sequencing System)
SCR_016137https://scicrunch.org/resolver/SCR_016137 SciCrunch identifier (RRID:SCR_016137, Microsoft Excel)
SCR_016499https://scicrunch.org/resolver/SCR_016499 SciCrunch identifier (RRID:SCR_016499, MotionCor2)
SCR_014224https://scicrunch.org/resolver/SCR_014224 SciCrunch identifier (RRID:SCR_014224, Phenix)
SCR_016274https://scicrunch.org/resolver/SCR_016274 SciCrunch identifier (RRID:SCR_016274, RELION)
SCR_014228https://scicrunch.org/resolver/SCR_014228 SciCrunch identifier (RRID:SCR_014228, Sparky)
SCR_025773https://scicrunch.org/resolver/SCR_025773 SciCrunch identifier (RRID:SCR_025773, Thermo Fisher: Vitrobot Mark IV system)
SCR_014227https://scicrunch.org/resolver/SCR_014227 SciCrunch identifier (RRID:SCR_014227, TopSpin)
SCR_021351https://scicrunch.org/resolver/SCR_021351 SciCrunch identifier (RRID:SCR_021351, Zeiss Axio Observer)
SCR_020922https://scicrunch.org/resolver/SCR_020922 SciCrunch identifier (RRID:SCR_020922, Zeiss LSM 780 Confocal Laser Scanning Microscope)
SCR_013672https://scicrunch.org/resolver/SCR_013672 SciCrunch identifier (RRID:SCR_013672, ZEN Digital Imaging for Light Microscopy)
static-c...SM.pdfhttps://static-content.springer.com/esm/art%3A10.1186%2Fs13024-025-00889-y/MediaObjects/13024_2025_889_MOESM1_ESM.pdf Supplemental material
protocol...lpk/v1https://www.protocols.io/view/single-particle-analysis-of-synuclein-fibrils-81wgbxozylpk/v1 Supplemental material (protocol)
mbexc.de...tures/https://mbexc.de/de/a-novel-alpha-synuclein-g14r-missense-variant-is-associated-with-atypical-neuropathological-features/ Website entry (mbexc.de)