| Property |
Value |
| Working Groups |
RG Stadelmann-Nessler |
| Subproject |
None |
| Open Access |
Yes |
| Publication Type |
Journal Article |
| Peer Reviewed |
Yes |
| PMID |
41167189 |
| DOI |
10.1016/j.immuni.2025.10.003 |
| Publication Year |
2025 |
| Title |
Single-cell spatial transcriptomic profiling defines a pathogenic inflammatory niche in chronic active multiple sclerosis lesions |
| Journal |
Immunity |
| ISSN |
1074-7613 |
| eISSN |
1097-4180 |
| URL |
https://doi.org/10.1016/j.immuni.2025.10.003 |
| Journal Abbreviation |
Immunity |
| Authors |
Feng R, Spieth L, Liu L, Berghoff S, Franz J, Liu Q, Wang Z, Tiwari V, Vitale S, Frerich S, Florensa S, Junker N, Huber L, Keller M, Müller C, Bracher F, Ge X, Rensen PC, Kooij G, Hosang L, Chornyi S, Dichgans M, Gokce O, Saher G, Stadelmann C, Giera M, Groh J, Simons M |
| First Author |
Feng R |
| Last Author |
Simons M |
External Resources
cell.com...0433-9https://www.cell.com/immunity/pdfExtended/S1074-7613(25)00433-9 Article fulltext
2/152294http://resolver.sub.uni-goettingen.de/purl?2/152294 GRO.publications identifier
0000-0003-3590-4643https://orcid.org/0000-0003-3590-4643 ORCID identifier (Ruoqing Feng)
0000-0002-0308-0144https://orcid.org/0000-0002-0308-0144 ORCID identifier (Lena Spieth)
0000-0002-3794-7295https://orcid.org/0000-0002-3794-7295 ORCID identifier (Stefan Berghoff)
0000-0001-7523-6622https://orcid.org/0000-0001-7523-6622 ORCID identifier (Jonas Franz)
0009-0009-0335-5281https://orcid.org/0009-0009-0335-5281 ORCID identifier (Vini Tiwari)
0009-0002-9212-538Xhttps://orcid.org/0009-0002-9212-538X ORCID identifier (Simona Vitale)
0000-0002-8275-6113https://orcid.org/0000-0002-8275-6113 ORCID identifier (Simon Frerich)
0009-0006-9482-9048https://orcid.org/0009-0006-9482-9048 ORCID identifier (Niklas Junker)
0009-0004-6007-480Xhttps://orcid.org/0009-0004-6007-480X ORCID identifier (Ludwig Huber)
0000-0003-4792-3980https://orcid.org/0000-0003-4792-3980 ORCID identifier (Marco Keller)
0000-0003-0009-8629https://orcid.org/0000-0003-0009-8629 ORCID identifier (Franz Bracher)
0000-0003-0815-1076https://orcid.org/0000-0003-0815-1076 ORCID identifier (Xiaoke Ge)
0000-0002-8455-4988https://orcid.org/0000-0002-8455-4988 ORCID identifier (Patrick C.N. Rensen)
0000-0002-9488-2918https://orcid.org/0000-0002-9488-2918 ORCID identifier (Gijs Kooij)
0000-0001-7367-5322https://orcid.org/0000-0001-7367-5322 ORCID identifier (Leon Hosang)
0000-0003-4817-1127https://orcid.org/0000-0003-4817-1127 ORCID identifier (Serhii Chornyi)
0000-0002-0654-387Xhttps://orcid.org/0000-0002-0654-387X ORCID identifier (Martin Dichgans)
0000-0001-6319-404Xhttps://orcid.org/0000-0001-6319-404X ORCID identifier (Özgün Gökçe)
0000-0003-3507-9604https://orcid.org/0000-0003-3507-9604 ORCID identifier (Gesine Saher)
0000-0003-1766-5458https://orcid.org/0000-0003-1766-5458 ORCID identifier (Christine Stadelmann-Nessler)
0000-0003-1684-1894https://orcid.org/0000-0003-1684-1894 ORCID identifier (Martin Giera)
0000-0002-7628-0163https://orcid.org/0000-0002-7628-0163 ORCID identifier (Janos Groh)
0000-0001-5329-192Xhttps://orcid.org/0000-0001-5329-192X ORCID identifier (Mikael Jakob Simons)
268https://rdp.sfb274.de/literature/publications/268 Published Data Registry entry (TRR 274)
1/662https://mbexc.uni-goettingen.de/archive/1/662 Research Data Archive (supplemental material)
05grdyy37https://ror.org/05grdyy37 ROR identifier (05grdyy37, Amsterdam University Medical Centers)
043j0f473https://ror.org/043j0f473 ROR identifier (043j0f473, German Center for Neurodegenerative Diseases)
02jet3w32https://ror.org/02jet3w32 ROR identifier (02jet3w32, Klinikum der Universität München)
027bh9e22https://ror.org/027bh9e22 ROR identifier (027bh9e22, Leiden University)
05591te55https://ror.org/05591te55 ROR identifier (05591te55, Ludwig-Maximilians-Universität München)
03av75f26https://ror.org/03av75f26 ROR identifier (03av75f26, Max Planck Institute for Multidisciplinary Sciences)
05xy1nn52https://ror.org/05xy1nn52 ROR identifier (05xy1nn52, Multiscale Bioimaging)
025z3z560https://ror.org/025z3z560 ROR identifier (025z3z560, Munich Cluster for Systems Neurology)
02kkvpp62https://ror.org/02kkvpp62 ROR identifier (02kkvpp62, Technical University of Munich)
01xnwqx93https://ror.org/01xnwqx93 ROR identifier (01xnwqx93, University Hospital Bonn)
021ft0n22https://ror.org/021ft0n22 ROR identifier (021ft0n22, University Medical Center Göttingen)
cell.com...c1.pdfhttps://www.cell.com/cms/10.1016/j.immuni.2025.10.003/attachment/5e6e3142-c295-4be0-96c7-5c23f0a6a4b3/mmc1.pdf Supplemental material
goeseek.gwdguser.de/studies/258https://goeseek.gwdguser.de/studies/258 Supplemental material (goeseek study)
cell.com...2.xlsxhttps://www.cell.com/cms/10.1016/j.immuni.2025.10.003/attachment/3ff335fd-973f-44b6-bb75-9d62ff9f6860/mmc2.xlsx Supplemental material (table)
cell.com...3.xlsxhttps://www.cell.com/cms/10.1016/j.immuni.2025.10.003/attachment/db0b2897-350a-44f1-9370-f1a300bb8013/mmc3.xlsx Supplemental material (table)
cell.com...4.xlsxhttps://www.cell.com/cms/10.1016/j.immuni.2025.10.003/attachment/7e1479b0-e7c4-4b3b-9d68-5ac9b0c8e24c/mmc4.xlsx Supplemental material (table)
cell.com...5.xlsxhttps://www.cell.com/cms/10.1016/j.immuni.2025.10.003/attachment/67eba4e2-1750-4121-b021-5fc6d348c44c/mmc5.xlsx Supplemental material (table)
cell.com...6.xlsxhttps://www.cell.com/cms/10.1016/j.immuni.2025.10.003/attachment/f2437b11-ceb4-4e2e-92b4-51cd3e6f4dab/mmc6.xlsx Supplemental material (table)
cell.com...7.xlsxhttps://www.cell.com/cms/10.1016/j.immuni.2025.10.003/attachment/5ada86c1-cc33-4b13-8fbe-193a8f2cdbda/mmc7.xlsx Supplemental material (table)
cell.com...8.xlsxhttps://www.cell.com/cms/10.1016/j.immuni.2025.10.003/attachment/af0a2dc1-f6c1-44d7-bc64-beadb76835f0/mmc8.xlsx Supplemental material (table)
mbexc.de...sions/https://mbexc.de/single-cell-spatial-transcriptomic-profiling-defines-a-pathogenic-inflammatory-niche-in-chronic-active-multiple-sclerosis-lesions/ Website entry (mbexc.de)