| Property |
Value |
| Working Groups |
RG Griesinger, 
RG de Groot |
| Subproject |
None |
| Open Access |
Yes |
| Publication Type |
Journal Article |
| Peer Reviewed |
Yes |
| PMID |
41044155 |
| DOI |
10.1038/s41467-025-64443-6 |
| Publication Year |
2025 |
| Title |
Anle138b binds predominantly to the central cavity in lipidic Aβ₄₀ fibrils and modulates fibril formation |
| Journal |
Nature Communications |
| ISSN |
2041-1723 |
| URL |
https://doi.org/10.1038/s41467-025-64443-6 |
| Issue |
1 |
| Volume |
16 |
| Journal Abbreviation |
Nat Commun |
| Authors |
Han M, Frieg B, Matthes D, Leonov A, Ryazanov S, Giller K, Nimerovsky E, Stampolaki M, Xue K, Overkamp K, Dienemann C, Riedel D, Giese A, Becker S, de Groot BL, Schröder GF, Andreas LB, Griesinger C |
| First Author |
Han M |
| Last Author |
Griesinger C |
External Resources
nature.c...-6.pdfhttps://www.nature.com/articles/s41467-025-64443-6.pdf Article fulltext
53129https://bmrb.io/data_library/summary/index.php?bmrbId=53129 BMRB identifier (53129)
NCT04685265https://clinicaltrials.gov/ct2/show/NCT04685265 ClinicalTrials ID (NCT04685265, reused)
NCT06568237https://clinicaltrials.gov/ct2/show/NCT06568237 ClinicalTrials ID (NCT06568237, reused)
EMD-53880https://www.ebi.ac.uk/pdbe/emdb/EMD-53880 EMBL-EBI EMDB identifier (EMD-53880)
EMD-53882https://www.ebi.ac.uk/pdbe/emdb/EMD-53882 EMBL-EBI EMDB identifier (EMD-53882)
2/151223http://resolver.sub.uni-goettingen.de/purl?2/151223 GRO.publications identifier
44608289https://pubchem.ncbi.nlm.nih.gov/compound/44608289 NCBI PubChem (44608289, Emrusolmin)
0009-0004-8007-5711https://orcid.org/0009-0004-8007-5711 ORCID identifier (Mookyoung Han)
0000-0002-7877-0262https://orcid.org/0000-0002-7877-0262 ORCID identifier (Benedikt Frieg)
0000-0003-3969-6335https://orcid.org/0000-0003-3969-6335 ORCID identifier (Dirk Matthes)
0000-0002-5586-9382https://orcid.org/0000-0002-5586-9382 ORCID identifier (Andrei Leonov)
0000-0002-4149-7899https://orcid.org/0000-0002-4149-7899 ORCID identifier (Karin Giller)
0000-0003-3002-0718https://orcid.org/0000-0003-3002-0718 ORCID identifier (Evgeny Nimerovsky)
0000-0002-0144-4792https://orcid.org/0000-0002-0144-4792 ORCID identifier (Marianna Stampolaki)
0000-0002-2172-5110https://orcid.org/0000-0002-2172-5110 ORCID identifier (Christian Dienemann)
0000-0003-2970-6894https://orcid.org/0000-0003-2970-6894 ORCID identifier (Dietmar Riedel)
0000-0002-8238-4102https://orcid.org/0000-0002-8238-4102 ORCID identifier (Armin Giese)
0000-0003-2041-5740https://orcid.org/0000-0003-2041-5740 ORCID identifier (Stefan Becker)
0000-0003-3570-3534https://orcid.org/0000-0003-3570-3534 ORCID identifier (Bert L. de Groot)
0000-0003-1803-5431https://orcid.org/0000-0003-1803-5431 ORCID identifier (Gunnar F. Schröder)
0000-0003-3216-9065https://orcid.org/0000-0003-3216-9065 ORCID identifier (Loren B. Andreas)
0000-0002-1266-4344https://orcid.org/0000-0002-1266-4344 ORCID identifier (Christian Griesinger)
1235https://prod.mbexc.uni-goettingen.de/literature/publications/1235 Published Data Registry entry (MBExC, preprint)
9RAWhttps://www.rcsb.org/structure/9RAW RCSB PDB Identifier (DOI:10.2210/pdb9RAW/pdb)
9RAXhttps://www.rcsb.org/structure/9RAX RCSB PDB Identifier (DOI:10.2210/pdb9RAX/pdb)
8ovkhttps://www.rcsb.org/structure/8ovk RCSB PDB Identifier (DOI:10.2210/pdb8ovk/pdb, reused)
1/677https://mbexc.uni-goettingen.de/archive/1/677 Research Data Archive (supplemental material)
02nv7yv05https://ror.org/02nv7yv05 ROR identifier (02nv7yv05, Forschungszentrum Jülich)
024z2rq82https://ror.org/024z2rq82 ROR identifier (024z2rq82, Heinrich Heine University Düsseldorf)
03av75f26https://ror.org/03av75f26 ROR identifier (03av75f26, Max Planck Institute for Multidisciplinary Sciences)
05xy1nn52https://ror.org/05xy1nn52 ROR identifier (05xy1nn52, Multiscale Bioimaging)
SCR_014222https://scicrunch.org/resolver/SCR_014222 SciCrunch identifier (RRID:SCR_014222, Coot)
SCR_018392https://scicrunch.org/resolver/SCR_018392 SciCrunch identifier (RRID:SCR_018392, crYOLO)
SCR_016732https://scicrunch.org/resolver/SCR_016732 SciCrunch identifier (RRID:SCR_016732, CTFFIND)
SCR_008619https://scicrunch.org/resolver/SCR_008619 SciCrunch identifier (RRID:SCR_008619, Gnuplot)
SCR_014565https://scicrunch.org/resolver/SCR_014565 SciCrunch identifier (RRID:SCR_014565, GROMACS)
SCR_014479https://scicrunch.org/resolver/SCR_014479 SciCrunch identifier (RRID:SCR_014479, Inkscape)
SCR_016137https://scicrunch.org/resolver/SCR_016137 SciCrunch identifier (RRID:SCR_016137, Microsoft Excel)
SCR_014226https://scicrunch.org/resolver/SCR_014226 SciCrunch identifier (RRID:SCR_014226, MolProbity)
SCR_014224https://scicrunch.org/resolver/SCR_014224 SciCrunch identifier (RRID:SCR_014224, Phenix)
SCR_000305https://scicrunch.org/resolver/SCR_000305 SciCrunch identifier (RRID:SCR_000305, PyMOL)
SCR_008394https://scicrunch.org/resolver/SCR_008394 SciCrunch identifier (RRID:SCR_008394, Python)
SCR_016274https://scicrunch.org/resolver/SCR_016274 SciCrunch identifier (RRID:SCR_016274, RELION)
SCR_015872https://scicrunch.org/resolver/SCR_015872 SciCrunch identifier (RRID:SCR_015872, UCSF ChimeraX)
static-c...SM.pdfhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41467-025-64443-6/MediaObjects/41467_2025_64443_MOESM1_ESM.pdf Supplemental material
goeseek.gwdguser.de/studies/267https://goeseek.gwdguser.de/studies/267 Supplemental material (goeseek study)
static-c...SM.pdfhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41467-025-64443-6/MediaObjects/41467_2025_64443_MOESM2_ESM.pdf Supplemental material (reporting summary)
static-c...SM.pdfhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41467-025-64443-6/MediaObjects/41467_2025_64443_MOESM3_ESM.pdf Supplemental material (peer review)
static-c...M.xlsxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41467-025-64443-6/MediaObjects/41467_2025_64443_MOESM4_ESM.xlsx Supplemental material (source data)
mbexc.de...ation/https://mbexc.de/the-clinical-drug-candidate-anle138b-binds-predominantly-to-the-central-cavity-in-lipidic-a%ce%b2%e2%82%84%e2%82%80-fibrils-and-modulates-fibril-formation/ Website entry (mbexc.de)