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 External Resources

 nature.c...-9.pdfhttps://www.nature.com/articles/s41467-025-62971-9.pdf  Article fulltext

 8355https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=8355  NCBI taxonomy (clawed frog, Xenopus laevis)

 10090https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10090  NCBI taxonomy (mouse, Mus musculus)

 0000-0002-3357-1139https://orcid.org/0000-0002-3357-1139  ORCID identifier (Andreas Heim)

 0000-0001-8643-8748https://orcid.org/0000-0001-8643-8748  ORCID identifier (Shiya Cheng)

 0000-0003-1447-4509https://orcid.org/0000-0003-1447-4509  ORCID identifier (Florian Stengel)

 0000-0003-0025-8952https://orcid.org/0000-0003-0025-8952  ORCID identifier (Melina Schuh)

 0000-0001-6954-2287https://orcid.org/0000-0001-6954-2287  ORCID identifier (Thomas U. Mayer)

 PXD062261http://proteomecentral.proteomexchange.org/cgi/GetDataset?ID=PXD062261  Pride proteome dataset (PXD062261)

 1/639https://mbexc.uni-goettingen.de/archive/1/639  Research Data Archive (supplemental material)

 03av75f26https://ror.org/03av75f26  ROR identifier (03av75f26, Max Planck Institute for Multidisciplinary Sciences)

 05xy1nn52https://ror.org/05xy1nn52  ROR identifier (05xy1nn52, Multiscale Bioimaging)

 0546hnb39https://ror.org/0546hnb39  ROR identifier (0546hnb39, University of Konstanz)

 SCR_002285https://scicrunch.org/resolver/SCR_002285  SciCrunch identifier (RRID:SCR_002285, Fiji)

 SCR_014601https://scicrunch.org/resolver/SCR_014601  SciCrunch identifier (RRID:SCR_014601, ggplot2)

 SCR_017393https://scicrunch.org/resolver/SCR_017393  SciCrunch identifier (RRID:SCR_017393, ggrepel)

 SCR_002798https://scicrunch.org/resolver/SCR_002798  SciCrunch identifier (RRID:SCR_002798, GraphPad Prism)

 SCR_016137https://scicrunch.org/resolver/SCR_016137  SciCrunch identifier (RRID:SCR_016137, Microsoft Excel)

 SCR_015753https://scicrunch.org/resolver/SCR_015753  SciCrunch identifier (RRID:SCR_015753, Perseus)

 SCR_008394https://scicrunch.org/resolver/SCR_008394  SciCrunch identifier (RRID:SCR_008394, Python)

 SCR_001905https://scicrunch.org/resolver/SCR_001905  SciCrunch identifier (RRID:SCR_001905, R Project for Statistical Computing)

 SCR_000432https://scicrunch.org/resolver/SCR_000432  SciCrunch identifier (RRID:SCR_000432, RStudio)

 SCR_013672https://scicrunch.org/resolver/SCR_013672  SciCrunch identifier (RRID:SCR_013672, ZEN Digital Imaging for Light Microscopy)

 static-c...SM.pdfhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41467-025-62971-9/MediaObjects/41467_2025_62971_MOESM1_ESM.pdf  Supplemental material

 goeseek.gwdguser.de/studies/243https://goeseek.gwdguser.de/studies/243  Supplemental material (goeseek study)

 static-c...SM.pdfhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41467-025-62971-9/MediaObjects/41467_2025_62971_MOESM3_ESM.pdf  Supplemental material (peer review)

 static-c...SM.pdfhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41467-025-62971-9/MediaObjects/41467_2025_62971_MOESM2_ESM.pdf  Supplemental material (reporting summary)

 static-c...M.xlsxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41467-025-62971-9/MediaObjects/41467_2025_62971_MOESM4_ESM.xlsx  Supplemental material (source data)