| Property |
Value |
| Working Groups |
RG Wollnik |
| Subproject |
None |
| Open Access |
Yes |
| Publication Type |
Journal Article |
| Peer Reviewed |
Yes |
| PMID |
39253995 |
| DOI |
10.1002/1878-0261.13725 |
| Publication Year |
2024 |
| Title |
KRASG12C‐inhibitor‐based combination therapies for pancreatic cancer: insights from drug screening |
| Journal |
Molecular Oncology |
| ISSN |
1574-7891 |
| eISSN |
1878-0261 |
| URL |
http://dx.doi.org/10.1002/1878-0261.13725 |
| Journal Abbreviation |
Mol Oncol |
| Authors |
Tapia Contreras C, Falke JD, Seifert D, Schneider C, Krauß L, Fang X, Müller D, Demirdizen E, Spitzner M, De Oliveira T, Schneeweis C, Gaedcke J, Kaulfuß S, Mirzakhani K, Wollnik B, Conrads K, Beißbarth T, Salinas G, Hügel J, Beyer N, Rheinländer S, Sax U, Wirth M, Conradi L, Reichert M, Ellenrieder V, Ströbel P, Ghadimi M, Grade M, Saur D, Hessmann E, Schneider G |
| First Author |
Tapia Contreras C |
| Last Author |
Schneider G |
External Resources
febs.onl...d=truehttps://febs.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1878-0261.13725?download=true Article fulltext
2/145530https://publications.goettingen-research-online.de/handle/2/145530 GRO.publications identifier
451668https://pubchem.ncbi.nlm.nih.gov/compound/451668 NCBI PubChem (451668, Decitabine)
54761306https://pubchem.ncbi.nlm.nih.gov/compound/54761306 NCBI PubChem (54761306, Ceralasertib)
92136227https://pubchem.ncbi.nlm.nih.gov/compound/92136227 NCBI PubChem (92136227, N1-((4-(4-isopropoxyphenyl)-1H-pyrrol-3-yl)methyl)-N1-methylethane-1,2-diamine)
118238370https://pubchem.ncbi.nlm.nih.gov/compound/118238370 NCBI PubChem (118238370, Batoprotafib)
137278711https://pubchem.ncbi.nlm.nih.gov/compound/137278711 NCBI PubChem (137278711, Sotorasib)
138911318https://pubchem.ncbi.nlm.nih.gov/compound/138911318 NCBI PubChem (138911318, N-((R)-1-(3-amino-5-(trifluoromethyl)phenyl)ethyl)-7-methoxy-2-methyl-6-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-4-amine)
Nintedanibhttps://pubchem.ncbi.nlm.nih.gov/compound/Nintedanib NCBI PubChem (Nintedanib)
9606https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 NCBI taxonomy (human, Homo sapiens)
0000-0001-6231-7431https://orcid.org/0000-0001-6231-7431 ORCID identifier (Denise Müller)
0000-0003-2577-9711https://orcid.org/0000-0003-2577-9711 ORCID identifier (Silke Kaulfuß)
0000-0003-2589-0364https://orcid.org/0000-0003-2589-0364 ORCID identifier (Bernd Wollnik)
0009-0006-4536-8564https://orcid.org/0009-0006-4536-8564 ORCID identifier (Karly Conrads)
0000-0001-6509-2143https://orcid.org/0000-0001-6509-2143 ORCID identifier (Tim Beißbarth)
0000-0001-8269-2669https://orcid.org/0000-0001-8269-2669 ORCID identifier (Gabriela Salinas-Riester)
0000-0002-4183-1287https://orcid.org/0000-0002-4183-1287 ORCID identifier (Jonas Hügel)
0000-0002-5489-3575https://orcid.org/0000-0002-5489-3575 ORCID identifier (Nils Hendrik Beyer)
0000-0002-5406-4427https://orcid.org/0000-0002-5406-4427 ORCID identifier (Sophia Rheinländer)
0000-0002-8188-3495https://orcid.org/0000-0002-8188-3495 ORCID identifier (Ulrich Sax)
0000-0002-8340-0872https://orcid.org/0000-0002-8340-0872 ORCID identifier (Matthias Wirth)
0000-0002-9488-1018https://orcid.org/0000-0002-9488-1018 ORCID identifier (Lena-Christin Conradi)
0000-0001-9981-8571https://orcid.org/0000-0001-9981-8571 ORCID identifier (Volker Ellenrieder)
0000-0002-8528-8060https://orcid.org/0000-0002-8528-8060 ORCID identifier (Philipp Ströbel)
0000-0001-8208-1526https://orcid.org/0000-0001-8208-1526 ORCID identifier (Michael Ghadimi)
0000-0001-5874-0210https://orcid.org/0000-0001-5874-0210 ORCID identifier (Dieter Saur)
0000-0002-9462-1291https://orcid.org/0000-0002-9462-1291 ORCID identifier (Elisabeth Hessmann)
0000-0003-1840-4508https://orcid.org/0000-0003-1840-4508 ORCID identifier (Günter Schneider)
1/507https://mbexc.uni-goettingen.de/archive/1/507 Research Data Archive (supplemental material)
001w7jn25https://ror.org/001w7jn25 ROR identifier (001w7jn25, Charité - Universitätsmedizin Berlin)
05xy1nn52https://ror.org/05xy1nn52 ROR identifier (05xy1nn52, Multiscale Bioimaging)
04jc43x05https://ror.org/04jc43x05 ROR identifier (04jc43x05, Rechts der Isar Hospital)
02kkvpp62https://ror.org/02kkvpp62 ROR identifier (02kkvpp62, Technical University of Munich)
021ft0n22https://ror.org/021ft0n22 ROR identifier (021ft0n22, University Medical Center Göttingen)
CVCL_0152https://scicrunch.org/resolver/CVCL_0152 SciCrunch identifier (RRID:CVCL_0152, AsPC-1)
CVCL_0045https://scicrunch.org/resolver/CVCL_0045 SciCrunch identifier (RRID:CVCL_0045, HEK293)
CVCL_0063https://scicrunch.org/resolver/CVCL_0063 SciCrunch identifier (RRID:CVCL_0063, HEK293T)
CVCL_0428https://scicrunch.org/resolver/CVCL_0428 SciCrunch identifier (RRID:CVCL_0428, MIA PaCa-2)
CVCL_4892https://scicrunch.org/resolver/CVCL_4892 SciCrunch identifier (RRID:CVCL_4892, PS-1 [Human urinary bladder carcinoma])
SCR_019214https://scicrunch.org/resolver/SCR_019214 SciCrunch identifier (RRID:SCR_019214, biomaRt)
SCR_017133https://scicrunch.org/resolver/SCR_017133 SciCrunch identifier (RRID:SCR_017133, ClustVis)
SCR_012802https://scicrunch.org/resolver/SCR_012802 SciCrunch identifier (RRID:SCR_012802, edgeR)
SCR_002344https://scicrunch.org/resolver/SCR_002344 SciCrunch identifier (RRID:SCR_002344, Ensembl)
SCR_000141https://scicrunch.org/resolver/SCR_000141 SciCrunch identifier (RRID:SCR_000141, FastQ Screen)
SCR_014583https://scicrunch.org/resolver/SCR_014583 SciCrunch identifier (RRID:SCR_014583, FastQC)
SCR_002798https://scicrunch.org/resolver/SCR_002798 SciCrunch identifier (RRID:SCR_002798, GraphPad Prism)
SCR_021058https://scicrunch.org/resolver/SCR_021058 SciCrunch identifier (RRID:SCR_021058, GSVA)
SCR_011867https://scicrunch.org/resolver/SCR_011867 SciCrunch identifier (RRID:SCR_011867, htseq-count)
SCR_016381https://scicrunch.org/resolver/SCR_016381 SciCrunch identifier (RRID:SCR_016381, Illumina NextSeq 550 System)
SCR_005484https://scicrunch.org/resolver/SCR_005484 SciCrunch identifier (RRID:SCR_005484, Kraken)
SCR_014982https://scicrunch.org/resolver/SCR_014982 SciCrunch identifier (RRID:SCR_014982, MultiQC)
SCR_001905https://scicrunch.org/resolver/SCR_001905 SciCrunch identifier (RRID:SCR_001905, R Project for Statistical Computing)
SCR_004463https://scicrunch.org/resolver/SCR_004463 SciCrunch identifier (RRID:SCR_004463, STAR)
SCR_011848https://scicrunch.org/resolver/SCR_011848 SciCrunch identifier (RRID:SCR_011848, Trimmomatic)
febs.onl...S4.pdfhttps://febs.onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1002%2F1878-0261.13725&file=mol213725-sup-0001-FigsS1-S4.pdf Supplemental material (figure)
goeseek.gwdguser.de/studies/197https://goeseek.gwdguser.de/studies/197 Supplemental material (goeseek study)
febs.onl...1.xlsxhttps://febs.onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1002%2F1878-0261.13725&file=mol213725-sup-0002-TableS1.xlsx Supplemental material (table)
mbexc.de...ing-2/https://mbexc.de/krasg12c-inhibitor-based-combination-therapies-for-pancreatic-cancer-insights-from-drug-screening-2/ Website entry (mbexc.de)
Linked Antibodies
| PID |
AG |
Type |
Antigen symbol |
Antibody Registry ID |
Name |
| primary-1703 |
|
primary |
KRAS |
AB_1842235 |
Monoclonal Anti-KRAS antibody produced in mouse |
| primary-1704 |
|
primary |
MK03 |
AB_2315112 |
Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (D13.14.4E) XP® Rabbit mAb |
| primary-1705 |
|
primary |
|
AB_10693601 |
p44/42 MAPK (Erk1/2) (137F5) Rabbit mAb (HRP Conjugate) |
| primary-1706 |
|
primary |
HSP90 |
AB_675659 |
HSP90 alpha/beta Antibody (F-8) |
| secondary-1707 |
|
secondary |
|
AB_10262463 |
Rabbit IgG (H+L chain) Goat Polyclonal Antibody |
| secondary-1708 |
|
secondary |
|
AB_10266129 |
Mouse IgG (H+L chain) Rabbit Polyclonal Antibody |